Evaluating teeth as fossil records of children's prenatal/perinatal trauma exposure and future mental health risk
评估牙齿作为儿童产前/围产期创伤暴露和未来心理健康风险的化石记录
基本信息
- 批准号:10354569
- 负责人:
- 金额:$ 28.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-01 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:AffectAgeAnthropologyAnxietyArchaeologyBiologicalBiological MarkersBostonBrainBreast FeedingCalendarChildConfocal MicroscopyDataData AnalysesDental EnamelDentinDevelopmentDistressElectronic Health RecordEventExposure toFetal DevelopmentFossilsFundingFutureGrowthHealthHistologyImageInterruptionKnowledgeLasersLifeLife Cycle StagesLightLinkMeasurementMeasuresMental DepressionMental HealthMental disordersMethodsMoodsMothersNatural experimentNewborn InfantPathway interactionsPatient Self-ReportPatternPerinatalPhysiologicalPopulationPregnancyProcessPsyche structurePsychological StressPsychopathologyPsychosocial StressRecording of previous eventsRecordsResearchRiskSchool-Age PopulationSecond Pregnancy TrimesterSeveritiesShapesStressStressful EventSymptomsTechniquesTestingThird Pregnancy TrimesterTimeTooth structureTraumaTreesWidthWomanWorkbasebiobankcytokinedeciduous toothearly detection biomarkersearly life stressexperiencein uteroinsightlifestyle factorslight microscopymaternal stressmicroCTmineralizationmolecular markerneuropsychiatrynovel strategiesoffspringperinatal periodphysical conditioningpilot testpregnantprenatalprepregnancypsychological stressorpsychosocialpsychosocial stressorsrepositoryresponsestressortooltrauma exposuretraumatic event
项目摘要
According to the “prenatal programming of mental illness” hypothesis, the prenatal period is one of the earliest
sensitive periods in development when maternal psychosocial stress exposure can have enduring effects on
offspring mental health. Currently, many measurement tools exist to characterize the occurrence of maternal
psychosocial stress exposure (e.g., depression; anxiety, stressful life events, etc). However, these measures
may not fully record the presence and timing of these experiences, especially when administered to mothers
retrospectively. To better assess the biological consequences of maternal psychosocial stressors on children,
objective tools are additionally needed to capture the prenatal and perinatal presence and timing of maternal
stressful life experiences. With a broader array of available tools, our field will be better poised to identify
children who are most vulnerable and intervene. Our group has been exploring children’s shed primary teeth
as objective and non-invasive tools that record the occurrence and timing of pre- and perinatal stressful life
events. Since teeth provide a fossilized record of their formation process, our working hypothesis is that early
life stressors– and particularly the timing of these psychosocial events – can be non-invasively measured in
shed teeth that began forming in utero. In this R21, we will test this hypothesis across two aims by analyzing
data collected from a separately-funded study called STRONG (Stories Teeth Record of Newborn Growth).
STRONG was funded in 2019 to build a biorepository of teeth from children whose mothers were exposed to
the 2013 Boston Marathon Bombing and manhunt events. In Aim 1, we will use techniques standardly
deployed in anthropology/archaeology (e.g., microCT imaging; histology; light microscopy) alongside newer
approaches (e.g., laser confocal microscopy) to derive a stress and other markers in teeth and determine the
parameters for when and how the Marathon bombing is visible in shed teeth. In Aim 2, we will pair these tooth-
based measures with subjective (self-report and electronic-health records) data of the bombing exposure to
compare the strength of the association between these two sets of measures on levels of child
psychopathology symptoms. As far as we know, this study would be the first to determine the degree to which
primary teeth mark the presence and timing of maternal psychological stress in relation to a traumatic event. If
validated as biomarkers, teeth would transform the study of sensitive periods by providing a new, non-invasive
measure for capturing and dating pre- and perinatal psychosocial exposures. Teeth could be used alongside
existing tools to screen children for early life stress exposure and to understand its biological consequences.
根据“心理疾病的产前规划”假说,产前是最早的时期之一
在发育的敏感期,母亲的心理社会压力暴露可能会对
后代的心理健康。目前,存在许多测量工具来表征母体疾病的发生
心理社会压力暴露(例如,抑郁、焦虑、有压力的生活事件等)。然而,这些措施
可能不会完全记录这些经历的存在和时机,特别是在给母亲注射的时候
追溯。为了更好地评估母亲心理社会应激源对儿童的生物学后果,
此外,还需要客观的工具来捕捉产前和围产期的存在和母婴的时间
有压力的生活经历。有了更广泛的可用工具,我们的现场将更好地确定
最易受伤害和干预的儿童。我们小组一直在探索儿童的乳牙脱落
作为客观和非侵入性的工具,记录产前和围产期应激生活的发生和时机
事件。由于牙齿提供了它们形成过程的僵化记录,我们的工作假设是早期
生活压力源--尤其是这些心理社会事件的时间--可以无创地测量
在子宫里开始形成的脱落的牙齿。在本R21中,我们将通过分析以下两个目标来测试这一假设
数据收集自一项名为Strong(故事牙齿新生儿生长记录)的单独资助的研究。
Strong于2019年获得资金,用于建立一个儿童牙齿生物储存库,这些儿童的母亲曾接触过
2013年波士顿马拉松爆炸案和搜捕事件。在目标1中,我们将标准化地使用技术
在人类学/考古学(例如,显微CT成像;组织学;光学显微镜)中与较新的
方法(例如,激光共聚焦显微镜)得出牙齿中的应力和其他标记,并确定
马拉松爆炸案的时间和方式的参数在牙齿脱落时可见。在目标2中,我们将配对这些牙齿-
基于轰炸暴露的主观(自我报告和电子健康记录)数据的测量
比较这两组测量在儿童水平上的关联性的强度
精神病态症状。据我们所知,这项研究将是第一次确定
乳牙标志着与创伤事件有关的母亲心理压力的存在和时机。如果
被证实为生物标志物的牙齿将通过提供一种新的、非侵入性的
测量出生前和围产期心理社会暴露的时间和时间。牙齿可以与牙齿一起使用
现有的工具用于筛查儿童早期生活压力暴露并了解其生物学后果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Erin Cathleen Dunn其他文献
Erin Cathleen Dunn的其他文献
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{{ truncateString('Erin Cathleen Dunn', 18)}}的其他基金
Genomic and bioinformatic approaches for understanding the effects of childhood adversity on primary tooth formation and caries development in young children
基因组和生物信息学方法用于了解童年逆境对幼儿乳牙形成和龋齿发展的影响
- 批准号:
10739519 - 财政年份:2023
- 资助金额:
$ 28.84万 - 项目类别:
Sensitive periods for prenatal alcohol exposure: a longitudinal study of DNA methylation and subsequent mental health
产前酒精暴露的敏感期:DNA 甲基化和随后心理健康的纵向研究
- 批准号:
10573715 - 财政年份:2023
- 资助金额:
$ 28.84万 - 项目类别:
Epigenetic predictors of time-varying exposures to childhood adversity and depression
童年逆境和抑郁随时间变化的表观遗传预测因子
- 批准号:
10645726 - 财政年份:2023
- 资助金额:
$ 28.84万 - 项目类别:
Childhood adversity, DNA methylation, and risk for depression: A longitudinal study of protective factors and sensitive periods in development
童年逆境、DNA 甲基化和抑郁风险:保护因素和发育敏感期的纵向研究
- 批准号:
10658070 - 财政年份:2023
- 资助金额:
$ 28.84万 - 项目类别:
Evaluating teeth as fossil records of children's prenatal/perinatal trauma exposure and future mental health risk
评估牙齿作为儿童产前/围产期创伤暴露和未来心理健康风险的化石记录
- 批准号:
10580772 - 财政年份:2022
- 资助金额:
$ 28.84万 - 项目类别:
Childhood adversity, DNA methylation, and risk for depression: A longitudinal study of sensitive periods in development
童年逆境、DNA 甲基化和抑郁风险:发育敏感期的纵向研究
- 批准号:
9377336 - 财政年份:2017
- 资助金额:
$ 28.84万 - 项目类别:
Childhood adversity, DNA methylation, and psychopathology symptoms: A longitudinal study of sensitive periods and chrono-epigenetics
童年逆境、DNA 甲基化和精神病理学症状:敏感期和时间表观遗传学的纵向研究
- 批准号:
10444309 - 财政年份:2017
- 资助金额:
$ 28.84万 - 项目类别:
Childhood adversity, DNA methylation, and psychopathology symptoms: A longitudinal study of sensitive periods and chrono-epigenetics
童年逆境、DNA 甲基化和精神病理学症状:敏感期和时间表观遗传学的纵向研究
- 批准号:
10602521 - 财政年份:2017
- 资助金额:
$ 28.84万 - 项目类别:
Childhood adversity, DNA methylation, and risk for depression: A longitudinal study of sensitive periods in development
童年逆境、DNA 甲基化和抑郁风险:发育敏感期的纵向研究
- 批准号:
9893016 - 财政年份:2017
- 资助金额:
$ 28.84万 - 项目类别:
Genes, early adversity, and sensitive periods in social-emotional development
基因、早期逆境和社会情感发展的敏感期
- 批准号:
8765685 - 财政年份:2014
- 资助金额:
$ 28.84万 - 项目类别:
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