Quantitative Analysis of Carpal Kinematics Using 3D Dynamic MRI
使用 3D 动态 MRI 定量分析腕骨运动学
基本信息
- 批准号:10354380
- 负责人:
- 金额:$ 17.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAnatomyAnkleBasic ScienceCadaverCartilageClinicalClinical PathologyClinical assessmentsComplexDegenerative polyarthritisDevelopmentDiagnosisDigit structureDiseaseDistalEarly DiagnosisEvaluationFluoroscopyForearmFractureFunctional disorderGoalsHandImaging TechniquesIn VitroIncidenceInjuryIonizing radiationJointsLeadLigamentsLong-Term EffectsMagnetic Resonance ImagingMeasurementMetacarpal boneMethodsMotionMovementMuscleNatureOperative Surgical ProceduresOutcomePainPathologicPatientsPatternPhysiologic pulsePositioning AttributePropertyProsthesisRadialRadiology SpecialtyReproducibilityRheumatoid ArthritisRoentgen RaysRotationSamplingSchemeScientistShapesStructureTechniquesThree-Dimensional ImageTimeTranslationsVisualizationWorkWristWrist Injuriesautomated segmentationbasecarpus boneclinical examinationclinical translationclinically relevantclinically significantfallshealinghealthy volunteerimage processingimaging approachimprovedin vivoinsightkinematicsligament injuryneuromuscularnon-invasive imagingnovelprematureradiological imagingreal-time imagesskeletalsoft tissuetemporal measurementtheoriesthree-dimensional visualizationtooltwo-dimensionalulnavalidation studiesvolunteerwrist functionwrist motion
项目摘要
Project Summary/Abstract
The wrist is a complex and versatile structure, which allows a substantial degree of three-dimensional motion.
To adequately diagnose and treat carpal injuries, it is important to understand the basic science and clinical
relevance of functional kinematics of the wrist. However, the analysis of carpal kinematics is challenging due to
the multiplanar rotations and translations of the carpal bones, the irregularity of their shape, and the small
magnitudes of movements. Most studies have been performed in vitro on cadaveric wrists, and in vivo
approaches based on noninvasive imaging have been proposed only recently. Initial in vivo work used CT or
MRI to obtain three-dimensional (3D) images of carpal bones at multiple static poses of the hand to reconstruct
an animated movement pattern. Since true dynamic joint kinematics may deviate from its animated counterpart,
more recent work has explored the possibility of real-time imaging during continuous wrist motion using 4D CT,
fluoroscopy and two-dimensional (2D) dynamic MRI. However, these methods either involves ionizing radiation
or cannot capture out-of-plane translations and rotations that occur even during relatively simple wrist
movements, because of their 2D nature. In this project, we will develop a new technique for quantitative analysis
of carpal kinematics based, for the first time, on 3D dynamic MRI acquisitions. We will develop a processing
pipeline that will combine automated segmentation of the carpal bones and the extraction of their motion patterns
during ulnar-radial deviation and flexion-extension of the wrist. We will conduct a pilot validation study on healthy
volunteers and patients with clinical evidence of carpal instability, with the goal of characterizing normal wrist
kinematics and identifying quantitative metrics to detect pathologic wrist conditions. We will also investigate an
alternative imaging approach based on the combination of parallel MRI and compressed sensing to further
accelerate the 3D dynamic MRI. Toward the end of the project, we will validate this new dynamic imaging
technique to assess whether the improved temporal resolution is clinically significant for the analysis of carpal
kinematics. Successful completion of this project will provide a new, 3D MRI-based technique for in vivo
characterization and visualization of 3D skeletal kinematics, providing novel insights into normal wrist function
and pathophysiology of wrist instability. Our proposed automated image processing pipeline will facilitate clinical
translation. The ability to assess dynamic motion patterns will contribute to diagnosis, therapy, and prosthesis
development for wrist disorders, enabling to evaluate the long-term effects of healing and surgical intervention.
The proposed technique could also have an impact for the dynamic evaluation of other anatomical structures
such as, for example, the ankle.
项目摘要/摘要
手腕是一种复杂而多才多艺的结构,它允许相当程度的三维运动。
为了更好地诊断和治疗腕部损伤,了解基础科学和临床是重要的。
腕关节功能运动学的相关性。然而,腕部运动学的分析是具有挑战性的,因为
腕骨的多平面旋转和平移,其形状的不规则性,以及小的
运动的大小。大多数研究都是在身体手腕上进行的,在体内也是如此。
基于非侵入性成像的方法直到最近才被提出。最初的活体工作使用CT或
磁共振成像获取手部多个静态姿势下的腕骨三维(3D)图像以进行重建
一种生动的运动模式。由于真正的动态关节运动学可能会偏离其动画对应物,
最近的工作探索了使用4D CT在连续腕部运动期间进行实时成像的可能性,
透视和二维(2D)动态磁共振成像。然而,这些方法要么涉及电离辐射
或者不能捕捉即使在相对简单的手腕上也会发生的平面外平移和旋转
运动,因为它们的2D性质。在这个项目中,我们将开发一种新的定量分析技术
首次基于3D动态MRI采集的腕部运动学研究。我们将开发一种处理
将结合自动分割腕骨和提取其运动模式的流水线
在尺骨偏斜和腕关节屈伸的过程中。我们将进行一项关于健康的先导验证研究
志愿者和有腕关节不稳定临床证据的患者,目的是描述正常腕关节的特征
运动学和识别定量指标,以检测病理手腕状况。我们还将调查一名
基于并行MRI和压缩感知相结合的替代成像方法
加速三维动态核磁共振成像。在项目接近尾声时,我们将验证这种新的动态成像
评估改进的时间分辨率对于腕骨分析是否具有临床意义的技术
运动学。该项目的成功完成将为活体研究提供一种新的基于3D MRI的技术
3D骨骼运动学的表征和可视化,提供了对正常腕部功能的新见解
以及腕关节不稳定的病理生理学。我们建议的自动图像处理流水线将有助于临床
翻译。评估动态运动模式的能力将有助于诊断、治疗和假体修复
手腕疾病的发展,使之能够评估愈合和手术干预的长期效果。
所提出的技术也可能对其他解剖结构的动态评估产生影响
例如脚踝。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Riccardo Lattanzi其他文献
Riccardo Lattanzi的其他文献
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{{ truncateString('Riccardo Lattanzi', 18)}}的其他基金
Quantitative Analysis of Carpal Kinematics Using 3D Dynamic MRI
使用 3D 动态 MRI 定量分析腕骨运动学
- 批准号:
10554164 - 财政年份:2022
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9925779 - 财政年份:2017
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