Hip Chondromics: Comprehensive Cartilage Characterization with MR Fingerprinting

髋关节软骨组学：利用 MR 指纹图谱进行综合软骨表征

• 批准号: 9526421
• 负责人: Riccardo Lattanzi
• 金额: $ 59.09万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9526421
• 关键词: 3-Dimensional; Address; Anatomy; Arthrography; Arthroscopy; Articular Range of Motion; Biochemical; Biological Markers; Brain; Cartilage; Chronic Kidney Failure; Classification; Clinical; Clinical Management; Clinical assessments; Collagen; Contrast Media; Degenerative polyarthritis; Detection; Diagnostic; Diffusion; Dimensions; Discrimination; Early Diagnosis; Effectiveness; Evaluation; Exercise; Femur; Fingerprint; Functional disorder; Gadolinium; Goals; Head and neck structure; Hip Joint; Hip Osteoarthritis; Hip Prosthesis; Hip region structure; Image; Imagery; Injections; Joints; Knee; Lead; Left; Lesion; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Measurement; Measures; Mechanics; Methods; Monitor; Morphology; Operative Surgical Procedures; Outcome; Outcome Measure; Pain-Free; Pathologic; Patient Selection; Patients; Physiologic pulse; Procedures; Prognostic Factor; Proteoglycan; Reproducibility; Research; Resolution; Risk; Roentgen Rays; Scanning; Scheme; Secondary to; Severities; Software Tools; Staging; Standardization; Structural defect; Structure; System; Techniques; Technology; Testing; Time; Translating; United States; Validation; Water; Work; acetabulum; articular cartilage; base; cartilage degradation; cartilage repair; clinical translation; cost; data visualization; hip replacement arthroplasty; improved; in vivo; novel; outcome forecast; preservation; prevent; quantitative imaging; rapid technique; reconstruction; response; simulation; software development; success; validation studies

Project Summary/Abstract Hip Chondromics: comprehensive cartilage characterization with MR fingerprinting Femoroacetabular impingement (FAI) is a pathologic condition in which structural abnormalities of the femoral head-neck junction and/or acetabulum lead to a mechanical blockage in the hip joint that compromises the terminal range of motion. If the impingement is left untreated, it can cause cartilage damage and lead to hip osteoarthritis. The goal of this project is to demonstrate the utility of multi-parametric quantitative magnetic resonance (MR) imaging for the clinical management of FAI and to develop the technology necessary to translate it into clinical routine. We will conduct a longitudinal study using intraoperative cartilage assessment and clinical outcome measures to show, for the first time, that a combination of dGEMRIC (i.e., cartilage T1 mapping in the presence of gadolinium contrast agent) and T2 mapping can identify prognostic factors associated with successful FAI arthroscopy and improve surgical patient selection. Concurrently, we will develop a method to map multiple MR parameters simultaneously in one single scan and enable comprehensive morphologic and biochemical characterization of the hip cartilage without exogenous contrast agents (i.e., “Hip Chondromics”). This new technique will employ concepts from magnetic resonance fingerprinting (MRF) to create B1 insensitive 3D multi-parametric maps with isotropic resolution in clinically feasible scan time. In particular, we will develop a new strategy to simultaneously quantify T1, T2 and magnetization transfer (MT) rate using MR fingerprints, since the combination of these three parameters has demonstrated a strong correlation (r2 > 0.8) with direct measurements of cartilage biochemical components. To facilitate clinical translation of quantitative MR parameters in FAI, we will also develop and disseminate new software tools for automated segmentation of the hip cartilage, extraction of relevant diagnostic measures and optimized data visualization. Our technique will enable accurate preoperative assessment of articular cartilage damage, predict risk for progression, identify patients who will benefit from arthroscopy, and monitor the effectiveness of joint preserving surgeries, as well as cartilage repair procedures, in preventing hip osteoarthritis. Successful completion of this project will provide a new classification system for articular cartilage lesions in the hip, based on quantitative MR imaging, which is intrinsically more sensitive to early cartilage damage than standard X-ray and magnetic resonance imaging. Our proposed MRF technique will enable in vivo rapid volumetric multi-parametric mapping that could also have an impact for quantitative imaging in other anatomical structures such as, for example, the brain.

项目摘要/摘要 髋关节软骨病：MR指纹图的综合软骨特征 髋臼撞击(FAI)是股骨结构异常的一种病理状态 头颈交界处和/或髋臼导致髋关节机械性阻塞，危及 末端运动范围。如果撞击得不到治疗，可能会导致软骨损伤并导致髋关节。 骨性关节炎。本项目的目标是演示多参数定量磁学的实用性 磁共振成像用于FAI的临床治疗，并开发必要的技术 将其转化为临床常规。我们将使用术中软骨评估进行纵向研究。 和临床结果测量首次表明，dGEMRIC(即软骨T1)的组合 Gd造影剂存在时的标测)和T2标测可以识别预后因素 与FAI关节镜检查的成功相关，并改进手术患者的选择。同时，我们将 开发一种在一次扫描中同时映射多个MR参数的方法，并启用 无外源性造影剂的髋关节软骨的综合形态和生化特征 代理人(即“髋关节软骨”)。这项新技术将利用磁共振的概念 指纹分析(MRF)在临床中建立各向同性分辨率的B1不敏感三维多参数图 可行的扫描时间。特别是，我们将开发一种新的策略来同时量化T1、T2和 使用MR指纹的磁化转移(MT)速率，因为这三个参数的组合 与软骨生化成分的直接测量有很强的相关性(R2&GT；0.8)。至 促进定量磁共振参数在FAI中的临床翻译，我们还将开发和传播新的 用于自动分割髋关节软骨、提取相关诊断措施和 优化的数据可视化。我们的技术将使准确的术前关节软骨评估成为可能。 损伤，预测进展风险，确定将从关节镜检查中受益的患者，并监测 保留关节的手术以及软骨修复手术在预防髋关节疾病中的有效性 骨性关节炎。该项目的成功完成将为关节的分类提供一个新的系统 髋关节软骨损伤，基于定量磁共振成像，本质上对早期更敏感 软骨损伤程度高于标准X光和磁共振成像。我们建议的磁流变液技术将 实现体内快速体积多参数标测，这也可能对量化 在其他解剖结构中成像，例如大脑。