Quantitative Analysis of Carpal Kinematics Using 3D Dynamic MRI
使用 3D 动态 MRI 定量分析腕骨运动学
基本信息
- 批准号:10554164
- 负责人:
- 金额:$ 21.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAccelerationAnatomyAnkleBasic ScienceCadaverCartilageClinicalClinical PathologyComplexDegenerative polyarthritisDevelopmentDiagnosisDigit structureDiseaseDistalEarly DiagnosisEvaluationFluoroscopyForearmFractureFunctional disorderGoalsHandImageImaging TechniquesIn VitroIncidenceInjuryIonizing radiationJointsLigamentsLong-Term EffectsMagnetic Resonance ImagingMeasurementMetacarpal boneMethodsMotionMovementMuscleNatureOperative Surgical ProceduresOutcomePainPathologicPatientsPatternPhysiologic pulsePositioning AttributePropertyProsthesisRadialRadiology SpecialtyReproducibilityRheumatoid ArthritisRoentgen RaysRotationSamplingSchemeScientistShapesStructureTechniquesTimeTranslationsVisualizationWorkWristWrist Injuriesanimationautomated segmentationcarpus boneclinical examinationclinical translationclinically relevantclinically significantfallshealinghealthy volunteerimage processingimaging approachimprovedin vivoinsightkinematicsligament injuryneuromuscularnon-invasive imagingnovelprematureradiological imagingreal-time imagesskeletalsoft tissuetemporal measurementtheoriesthree-dimensional visualizationtooltwo-dimensionalulnavalidation studiesvolunteerwrist functionwrist motion
项目摘要
Project Summary/Abstract
The wrist is a complex and versatile structure, which allows a substantial degree of three-dimensional motion.
To adequately diagnose and treat carpal injuries, it is important to understand the basic science and clinical
relevance of functional kinematics of the wrist. However, the analysis of carpal kinematics is challenging due to
the multiplanar rotations and translations of the carpal bones, the irregularity of their shape, and the small
magnitudes of movements. Most studies have been performed in vitro on cadaveric wrists, and in vivo
approaches based on noninvasive imaging have been proposed only recently. Initial in vivo work used CT or
MRI to obtain three-dimensional (3D) images of carpal bones at multiple static poses of the hand to reconstruct
an animated movement pattern. Since true dynamic joint kinematics may deviate from its animated counterpart,
more recent work has explored the possibility of real-time imaging during continuous wrist motion using 4D CT,
fluoroscopy and two-dimensional (2D) dynamic MRI. However, these methods either involves ionizing radiation
or cannot capture out-of-plane translations and rotations that occur even during relatively simple wrist
movements, because of their 2D nature. In this project, we will develop a new technique for quantitative analysis
of carpal kinematics based, for the first time, on 3D dynamic MRI acquisitions. We will develop a processing
pipeline that will combine automated segmentation of the carpal bones and the extraction of their motion patterns
during ulnar-radial deviation and flexion-extension of the wrist. We will conduct a pilot validation study on healthy
volunteers and patients with clinical evidence of carpal instability, with the goal of characterizing normal wrist
kinematics and identifying quantitative metrics to detect pathologic wrist conditions. We will also investigate an
alternative imaging approach based on the combination of parallel MRI and compressed sensing to further
accelerate the 3D dynamic MRI. Toward the end of the project, we will validate this new dynamic imaging
technique to assess whether the improved temporal resolution is clinically significant for the analysis of carpal
kinematics. Successful completion of this project will provide a new, 3D MRI-based technique for in vivo
characterization and visualization of 3D skeletal kinematics, providing novel insights into normal wrist function
and pathophysiology of wrist instability. Our proposed automated image processing pipeline will facilitate clinical
translation. The ability to assess dynamic motion patterns will contribute to diagnosis, therapy, and prosthesis
development for wrist disorders, enabling to evaluate the long-term effects of healing and surgical intervention.
The proposed technique could also have an impact for the dynamic evaluation of other anatomical structures
such as, for example, the ankle.
项目总结/摘要
手腕是一个复杂而多功能的结构,它允许相当程度的三维运动。
为了充分诊断和治疗腕关节损伤,重要的是要了解基础科学和临床
腕关节功能运动学的相关性。然而,腕骨运动学的分析是具有挑战性的,
腕骨的多平面旋转和平移,其形状的不规则性,以及小的
运动的幅度。大多数研究都是在体外对尸体手腕进行的,
最近才提出了基于非侵入性成像的方法。初始体内工作使用CT或
MRI以获得手部多个静态姿势下腕骨的三维(3D)图像,以进行重建
一种生动的运动模式。由于真实的动态关节运动学可能偏离其动画对应物,
最近的工作已经探索了使用4DCT在连续手腕运动期间实时成像的可能性,
荧光透视和二维(2D)动态MRI。然而,这些方法要么涉及电离辐射,
或者不能捕获即使在相对简单的腕关节运动期间也发生的平面外平移和旋转
因为它们的2D特性。在这个项目中,我们将开发一种新的定量分析技术
腕关节运动学的基础上,第一次,在三维动态磁共振成像采集。我们将开发一种处理
将联合收割机自动分割腕骨和提取其运动模式相结合的流水线
在腕部的尺桡偏斜和屈伸期间。我们会进行一项试验性研究,
具有腕关节不稳定临床证据的志愿者和患者,目的是表征正常腕关节
运动学和识别定量度量以检测病理性腕部状况。我们还将调查
基于并行MRI和压缩感知的组合的替代成像方法,
加速3D动态MRI。在项目结束时,我们将验证这种新的动态成像
一种技术,以评估改善的时间分辨率是否对腕骨分析具有临床意义
运动学该项目的成功完成将提供一种新的,基于3D MRI的体内技术,
3D骨骼运动学的表征和可视化,为正常腕关节功能提供新的见解
和腕关节不稳定的病理生理学。我们提出的自动化图像处理管道将有助于临床
翻译.评估动态运动模式的能力将有助于诊断、治疗和修复
开发用于腕关节疾病的治疗工具,从而能够评估愈合和手术干预的长期效果。
所提出的技术也可能对其他解剖结构的动态评价产生影响
例如脚踝。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Riccardo Lattanzi其他文献
Riccardo Lattanzi的其他文献
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{{ truncateString('Riccardo Lattanzi', 18)}}的其他基金
Quantitative Analysis of Carpal Kinematics Using 3D Dynamic MRI
使用 3D 动态 MRI 定量分析腕骨运动学
- 批准号:
10354380 - 财政年份:2022
- 资助金额:
$ 21.24万 - 项目类别:
Cloud MR: an Open-Source Software Framework to Democratize MRI Training and Research
Cloud MR:使 MRI 培训和研究大众化的开源软件框架
- 批准号:
10587391 - 财政年份:2017
- 资助金额:
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Novel Software Tools for Rational Design and Assessment of MR Coils
用于磁流变线圈合理设计和评估的新型软件工具
- 批准号:
9925779 - 财政年份:2017
- 资助金额:
$ 21.24万 - 项目类别:
Novel Software Tools for Rational Design and Assessment of MR Coils
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- 批准号:
9364167 - 财政年份:2017
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Hip Chondromics: Comprehensive Cartilage Characterization with MR Fingerprinting
髋关节软骨组学:利用 MR 指纹图谱进行综合软骨表征
- 批准号:
9526421 - 财政年份:2016
- 资助金额:
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Hip Chondromics: Comprehensive Cartilage Characterization with MR Fingerprinting
髋关节软骨组学:利用 MR 指纹图谱进行综合软骨表征
- 批准号:
9975102 - 财政年份:2016
- 资助金额:
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Hip Chondromics: Comprehensive Cartilage Characterization with MR Fingerprinting
髋关节软骨组学:利用 MR 指纹图谱进行综合软骨表征
- 批准号:
10201516 - 财政年份:2016
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