Hip Chondromics: Comprehensive Cartilage Characterization with MR Fingerprinting

髋关节软骨组学：利用 MR 指纹图谱进行综合软骨表征

基本信息

批准号：
10201516
负责人：
Riccardo Lattanzi
金额：
$ 56.19万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10201516
关键词：
3-Dimensional Address Anatomy Arthrography Arthroscopy Articular Range of Motion Biochemical Biological Markers Brain Cartilage Chronic Kidney Failure Classification Clinical Clinical Management Clinical assessments Collagen Contrast Media Degenerative polyarthritis Detection Diagnostic Diffusion Discrimination Early Diagnosis Effectiveness Evaluation Exercise Femur Fingerprint Functional disorder Gadolinium Goals Head and neck structure Hip Joint Hip Osteoarthritis Hip Prosthesis Hip region structure Image Injections Joints Knee Lead Left Lesion Longitudinal Studies Magnetic Resonance Magnetic Resonance Imaging Maps Measurement Measures Mechanics Methods Monitor Morphology Operative Surgical Procedures Outcome Pain-Free Pathologic Patient Selection Patients Physiologic pulse Procedures Prognosis Prognostic Factor Proteoglycan Reproducibility Research Resolution Risk Roentgen Rays Scanning Scheme Secondary to Severities Software Tools Staging Standardization Structural defect Structure System Techniques Technology Testing Time Translating United States Validation Visualization Water Work acetabulum articular cartilage automated segmentation base cartilage degradation cartilage repair clinical outcome measures clinical translation cost data visualization hip replacement arthroplasty improved in vivo novel preservation prevent quantitative imaging rapid technique reconstruction response simulation software development success validation studies

项目摘要

Project Summary/Abstract Hip Chondromics: comprehensive cartilage characterization with MR fingerprinting Femoroacetabular impingement (FAI) is a pathologic condition in which structural abnormalities of the femoral head-neck junction and/or acetabulum lead to a mechanical blockage in the hip joint that compromises the terminal range of motion. If the impingement is left untreated, it can cause cartilage damage and lead to hip osteoarthritis. The goal of this project is to demonstrate the utility of multi-parametric quantitative magnetic resonance (MR) imaging for the clinical management of FAI and to develop the technology necessary to translate it into clinical routine. We will conduct a longitudinal study using intraoperative cartilage assessment and clinical outcome measures to show, for the first time, that a combination of dGEMRIC (i.e., cartilage T1 mapping in the presence of gadolinium contrast agent) and T2 mapping can identify prognostic factors associated with successful FAI arthroscopy and improve surgical patient selection. Concurrently, we will develop a method to map multiple MR parameters simultaneously in one single scan and enable comprehensive morphologic and biochemical characterization of the hip cartilage without exogenous contrast agents (i.e., “Hip Chondromics”). This new technique will employ concepts from magnetic resonance fingerprinting (MRF) to create B1 insensitive 3D multi-parametric maps with isotropic resolution in clinically feasible scan time. In particular, we will develop a new strategy to simultaneously quantify T1, T2 and magnetization transfer (MT) rate using MR fingerprints, since the combination of these three parameters has demonstrated a strong correlation (r2 > 0.8) with direct measurements of cartilage biochemical components. To facilitate clinical translation of quantitative MR parameters in FAI, we will also develop and disseminate new software tools for automated segmentation of the hip cartilage, extraction of relevant diagnostic measures and optimized data visualization. Our technique will enable accurate preoperative assessment of articular cartilage damage, predict risk for progression, identify patients who will benefit from arthroscopy, and monitor the effectiveness of joint preserving surgeries, as well as cartilage repair procedures, in preventing hip osteoarthritis. Successful completion of this project will provide a new classification system for articular cartilage lesions in the hip, based on quantitative MR imaging, which is intrinsically more sensitive to early cartilage damage than standard X-ray and magnetic resonance imaging. Our proposed MRF technique will enable in vivo rapid volumetric multi-parametric mapping that could also have an impact for quantitative imaging in other anatomical structures such as, for example, the brain.

项目摘要/摘要髋关节软骨学：MR指纹的全面软骨表征股骨替代撞击（FAI）是一种病理状况，股结构异常头颈连接和/或髋臼导致髋关节的机械阻塞，损害了终端运动范围。如果撞击未治疗，它可能会造成软骨损坏并导致髋关节骨关节炎。该项目的目的是证明多参数定量磁的实用性共鸣（MR）成像用于FAI的临床管理，并开发了必要的技术将其转换为临床常规。我们将使用术中软骨评估进行纵向研究和临床结局措施首次表明Dgemric的组合（即软骨T1 在存在Gadolinium对比剂的存在下的映射）和T2映射可以识别出概述因素与成功的FAI关节镜检查并改善手术患者的选择相关。同时，我们会的开发一种仅在一次扫描中映射多个MR参数的方法并启用髋软骨的全面形态和生化表征，没有外源对比度代理商（即“髋关节软骨学”）。这种新技术将采用磁共振中的概念指纹（MRF）以临床上的各向同性分辨率创建B1不敏感的3D多参数图可行的扫描时间。特别是，我们将制定一种新的策略来简单地量化T1，T2和使用MR指纹的磁化转移（MT）速率，因为这三个参数的组合具有与软骨生化成分的直接测量相关性（R2> 0.8）具有很强的相关性（R2> 0.8）。到促进FAI定量MR参数的临床翻译，我们还将开发并传播新的用于自动分割髋部软骨的软件工具，相关诊断措施的提取和优化的数据可视化。我们的技术将对关节软骨进行准确的术前评估损害，预测进展的风险，确定将从关节镜检查中受益的患者，并监测联合保存手术以及软骨修复程序的有效性，可防止髋关节骨关节炎。成功完成该项目将为关节提供新的分类系统基于定量MR成像，臀部的软骨病变本质上对早期更敏感软骨损伤比标准X射线和磁共振成像。我们提出的MRF技术将启用体内快速体积多参数映射，这也可能对定量产生影响在其他解剖结构中进行成像，例如大脑。