Enhancing rodent behavioral phenotyping using guided ultrasonic waves

使用引导超声波增强啮齿动物行为表型

基本信息

  • 批准号:
    10352676
  • 负责人:
  • 金额:
    $ 22.31万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-12-01 至 2023-11-30
  • 项目状态:
    已结题

项目摘要

Rodents are a cornerstone of neuroscience and physiology research, but the methods for monitoring behavior and physiology in these animals suffer from several key limitations. Monitoring physiological processes such as heart rate, breathing, and muscle activity requires invasive sensors that impede natural behavior of the animals. Similarly, behavioral assays can require highly constraining apparatus. This proposal is based on the hypothesis that we can greatly improve the sensitivity, accuracy, and reliability of rodent behavior quantification by taking advantage of a stream of information that, to date, has been completely ignored. When an animal is behaving in an environment, muscle contractions associated with breathing, heart rate, and voluntary and involuntary movements apply subtle forces to the surfaces the animal contacts. These forces generate elastic waves that propagate through the material (i.e., waveguide) at ultrasonic frequencies. The overarching hypothesis of this proposal is that these elastic waves − Guided Ultrasonic Waves (GUWs) − provide valuable information about mouse physiology, behavior, and underlying mental states. Under this proposal we will test the hypothesis that GUWs can be used to non-invasively track low-amplitude responses, such as breathing, heart rate, and startle, which currently can only be monitored using invasive or highly constraining apparatus. In addition, we predict that GUWs can be used to improve the sensitivity and accuracy with which other rodent behaviors can be identified and tracked. We will conduct experiments in which GUWs are recorded as mice explore an arena outfitted with piezoelectric sensors. We will simultaneously record information about physiology and behavior using traditional video tracking and implanted telemetry devices. By comparing these streams of information, we will identify GUW features that report mouse heart rate, startle, and a variety of other behaviors. In addition, we will use supervised and unsupervised machine learning approaches to develop GUW metrics that precisely and accurately classify behaviors that cannot be detected using current methods. Completion of these aims will yield hardware and associated analytics that will enhance the precision and objectivity of rodent behavior monitoring and allow researchers to simultaneously monitor behavior and physiology without the need for restrictive or invasive apparatus. Our goal is that the piezoelectric-based apparatus and associated analyses developed here will allow labs without specialized equipment or expertise to perform precise monitoring of mouse behavior and physiology without the need for invasive test equipment.
啮齿动物是神经科学和生理学研究的基石,但监测的方法

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MICHAEL R DREW其他文献

MICHAEL R DREW的其他文献

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{{ truncateString('MICHAEL R DREW', 18)}}的其他基金

Enhancing rodent behavioral phenotyping using guided ultrasonic waves
使用引导超声波增强啮齿动物行为表型
  • 批准号:
    10532791
  • 财政年份:
    2021
  • 资助金额:
    $ 22.31万
  • 项目类别:
Hippocampal Mechanisms of Fear Extinction
海马消除恐惧的机制
  • 批准号:
    10551331
  • 财政年份:
    2019
  • 资助金额:
    $ 22.31万
  • 项目类别:
Hippocampal Mechanisms of Fear Extinction
海马消除恐惧的机制
  • 批准号:
    10329899
  • 财政年份:
    2019
  • 资助金额:
    $ 22.31万
  • 项目类别:
Imaging adult-born neurons in action using head-mounted minimicroscopes
使用头戴式微型显微镜对活动中的成年神经元进行成像
  • 批准号:
    9203497
  • 财政年份:
    2016
  • 资助金额:
    $ 22.31万
  • 项目类别:
A viral system for light-dependent trapping of activated neurons
一种光依赖性捕获激活神经元的病毒系统
  • 批准号:
    9056270
  • 财政年份:
    2015
  • 资助金额:
    $ 22.31万
  • 项目类别:
Role of adult hippocampal neurogenesis in memory
成人海马神经发生在记忆中的作用
  • 批准号:
    8986212
  • 财政年份:
    2014
  • 资助金额:
    $ 22.31万
  • 项目类别:
Role of adult hippocampal neurogenesis in memory
成人海马神经发生在记忆中的作用
  • 批准号:
    8615500
  • 财政年份:
    2014
  • 资助金额:
    $ 22.31万
  • 项目类别:
Role of adult hippocampal neurogenesis in memory
成人海马神经发生在记忆中的作用
  • 批准号:
    8788555
  • 财政年份:
    2014
  • 资助金额:
    $ 22.31万
  • 项目类别:
Analyzing the Role of Adult Hippocampal Neurogenesis in Contextual Fear Memory
分析成人海马神经发生在情境恐惧记忆中的作用
  • 批准号:
    8090586
  • 财政年份:
    2010
  • 资助金额:
    $ 22.31万
  • 项目类别:
Analyzing the Role of Adult Hippocampal Neurogenesis in Contextual Fear Memory
分析成人海马神经发生在情境恐惧记忆中的作用
  • 批准号:
    8326534
  • 财政年份:
    2010
  • 资助金额:
    $ 22.31万
  • 项目类别:

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