Enhancing rodent behavioral phenotyping using guided ultrasonic waves
使用引导超声波增强啮齿动物行为表型
基本信息
- 批准号:10352676
- 负责人:
- 金额:$ 22.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-12-01 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:Animal BehaviorAnimal ExperimentsAnimalsAnxietyBehaviorBehavior ControlBehavior monitoringBehavioralBehavioral AssayBehavioral GeneticsBiomedical ResearchBreathingComputer Vision SystemsDataDetectionDevicesEnvironmentEquipmentFreezingFrequenciesFrightGaitGoalsHeart RateImplantInterventionInvoluntary MovementsLocomotionMachine LearningMeasuresMental HealthMethodsModalityMonitorMusMuscleMuscle ContractionMuscle TonusMusculoskeletalNeurosciencesOutcomePharmaceutical PreparationsPharmacologyPhasePhysiologic MonitoringPhysiologicalPhysiological ProcessesPhysiologyProcessProtocols documentationReportingResearchResearch MethodologyResearch PersonnelRespirationRestRodentSeizuresSignal TransductionStartle ReactionStreamSupervisionSurfaceTechniquesTelemetryTestingTimeUltrasonic waveUltrasonicsVariantanxiety-like behavioranxiousbasebehavior measurementbehavioral pharmacologybehavioral phenotypingexperimental studygenetic manipulationheart rate monitorimprovedmental statepublic health relevancerelating to nervous systemrespiratoryresponsesensortransmission processunsupervised learningvibrationwaveguidewireless
项目摘要
Rodents are a cornerstone of neuroscience and physiology research, but the methods for monitoring
behavior and physiology in these animals suffer from several key limitations. Monitoring physiological
processes such as heart rate, breathing, and muscle activity requires invasive sensors that impede natural
behavior of the animals. Similarly, behavioral assays can require highly constraining apparatus. This proposal
is based on the hypothesis that we can greatly improve the sensitivity, accuracy, and reliability of rodent
behavior quantification by taking advantage of a stream of information that, to date, has been completely
ignored. When an animal is behaving in an environment, muscle contractions associated with breathing, heart
rate, and voluntary and involuntary movements apply subtle forces to the surfaces the animal contacts. These
forces generate elastic waves that propagate through the material (i.e., waveguide) at ultrasonic frequencies.
The overarching hypothesis of this proposal is that these elastic waves − Guided Ultrasonic Waves (GUWs) −
provide valuable information about mouse physiology, behavior, and underlying mental states. Under this
proposal we will test the hypothesis that GUWs can be used to non-invasively track low-amplitude responses,
such as breathing, heart rate, and startle, which currently can only be monitored using invasive or highly
constraining apparatus. In addition, we predict that GUWs can be used to improve the sensitivity and accuracy
with which other rodent behaviors can be identified and tracked. We will conduct experiments in which GUWs
are recorded as mice explore an arena outfitted with piezoelectric sensors. We will simultaneously record
information about physiology and behavior using traditional video tracking and implanted telemetry devices. By
comparing these streams of information, we will identify GUW features that report mouse heart rate, startle,
and a variety of other behaviors. In addition, we will use supervised and unsupervised machine learning
approaches to develop GUW metrics that precisely and accurately classify behaviors that cannot be detected
using current methods. Completion of these aims will yield hardware and associated analytics that will enhance
the precision and objectivity of rodent behavior monitoring and allow researchers to simultaneously monitor
behavior and physiology without the need for restrictive or invasive apparatus. Our goal is that the
piezoelectric-based apparatus and associated analyses developed here will allow labs without specialized
equipment or expertise to perform precise monitoring of mouse behavior and physiology without the need for
invasive test equipment.
啮齿动物是神经科学和生理学研究的基石,但监测的方法
项目成果
期刊论文数量(0)
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会议论文数量(0)
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MICHAEL R DREW其他文献
MICHAEL R DREW的其他文献
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{{ truncateString('MICHAEL R DREW', 18)}}的其他基金
Enhancing rodent behavioral phenotyping using guided ultrasonic waves
使用引导超声波增强啮齿动物行为表型
- 批准号:
10532791 - 财政年份:2021
- 资助金额:
$ 22.31万 - 项目类别:
Imaging adult-born neurons in action using head-mounted minimicroscopes
使用头戴式微型显微镜对活动中的成年神经元进行成像
- 批准号:
9203497 - 财政年份:2016
- 资助金额:
$ 22.31万 - 项目类别:
A viral system for light-dependent trapping of activated neurons
一种光依赖性捕获激活神经元的病毒系统
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9056270 - 财政年份:2015
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Role of adult hippocampal neurogenesis in memory
成人海马神经发生在记忆中的作用
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8986212 - 财政年份:2014
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Role of adult hippocampal neurogenesis in memory
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8615500 - 财政年份:2014
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Role of adult hippocampal neurogenesis in memory
成人海马神经发生在记忆中的作用
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8788555 - 财政年份:2014
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Analyzing the Role of Adult Hippocampal Neurogenesis in Contextual Fear Memory
分析成人海马神经发生在情境恐惧记忆中的作用
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8090586 - 财政年份:2010
- 资助金额:
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Analyzing the Role of Adult Hippocampal Neurogenesis in Contextual Fear Memory
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- 批准号:
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