Expanding xenosurveillance capabilities in central America
扩大中美洲的异种监视能力
基本信息
- 批准号:10189517
- 负责人:
- 金额:$ 18.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-11 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcheAffectAfricaAmericasAngerAnimalsBiteBloodBlood capillariesBlood specimenCentral AmericaChildClinical DataClinical MedicineCommunicable DiseasesCommunitiesCulicidaeDataDetectionDevicesDiseaseDomestic AnimalsEbola virusEmerging Communicable DiseasesEnrollmentEntomologyEnvironmentEpidemicExanthemaFeverFrequenciesGuatemalaHateHealthHomeHourHouseholdHumanLaboratoriesLaboratory StudyLatin AmericaMethodologyMethodsMiddle EastMiddle East Respiratory Syndrome CoronavirusMidgutMindMonitorNeedlesPainPaperPathogen detectionPerformancePilot ProjectsPopulationProcessPublic HealthQuantitative Reverse Transcriptase PCRRNAReportingResourcesRuralSamplingSiteSpottingsSymptomsSyndromeSystemTemperatureTimeValidationVenipuncturesVenous blood samplingVeterinariansVeterinary MedicineViralVisiting NurseWorkYellow fever virusZoonosesbaseburden of illnesscohortdesigndetection limitemerging pathogenfield studyhealth economicsinnovationinsightmemberminimally invasivemultidisciplinarynext generation sequencingpandemic diseasepathogenpoor communitiesprospectivesurveillance datasyndromic surveillancetooltransmission processvirology
项目摘要
This proposal is for an R21, Expanding xenosurveillance capabilities in Central America. The project is a highly
multidisciplinary effort that includes collaborators with expertise in virology, public health entomology,
surveillance, and human clinical and veterinary medicine. Our study is based on the idea that mosquitoes can
serve as surveillance tools because they are essentially autonomous blood sampling devices. Freshly fed
mosquitoes are collected from within dwellings and blood is used for surveillance purposes. If successful, our
work would have the impact of simplifying certain types of surveillance that require human blood because
although most people hate it when they and their children are stuck with needles, they don’t seem to mind
mosquitoes being removed from within their homes. In addition, our approach has the potential to make
sampling from animals safer by vastly reducing the need for direct contact with fearful and angry animals that
bite, kick, etc..
Aim 1 focuses on validating xenosurveillance through a direct comparison to human-based syndromic
surveillance. Aim 2 is designed to maintain the scientific rigor of our work by obtaining quantitative estimates of
the sensitivity of Cx. quinquefasciatus and Ae. aegypti for xenosurveillance.
This proposal leverages significant prior work on xenosurveillance that has focused on An. gambiae in W.
Africa, and an ongoing pilot study of xenosurveillance in rural Guatemala.
这项提案是关于R21,扩大中美洲的异种监视能力。该项目是一个高度
多学科的努力,包括在病毒学,公共卫生昆虫学,
监测以及人类临床和兽医学。我们的研究是基于蚊子可以
因为它们基本上是自动血液取样装置。新鲜喂养的
蚊子是从住所内收集的,血液用于监测目的。如果成功,我们
这项工作将简化某些需要人血的监测类型,
尽管大多数人讨厌自己和孩子被针扎,但他们似乎并不介意
将蚊子从家中清除。此外,我们的方法有可能使
通过大大减少与恐惧和愤怒的动物直接接触的需要,从动物身上取样更安全,
咬、踢等。
目标1的重点是通过与基于人类的综合征的直接比较来验证异种监视
监视目标2的目的是通过获得以下方面的定量估计来保持我们工作的科学严谨性
Cx的敏感性。致倦五叠球菌和致倦五叠球菌。埃及用于异种监视。
该提案利用了之前关于异种监视的重要工作,这些工作集中在An上。gambiae在W.
非洲,以及正在危地马拉农村进行的异种监测试点研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gregory David Ebel其他文献
Gregory David Ebel的其他文献
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{{ truncateString('Gregory David Ebel', 18)}}的其他基金
Arbovirus population biology: temperature impacts on selection and collective dynamics
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- 资助金额:
$ 18.55万 - 项目类别:
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- 资助金额:
$ 18.55万 - 项目类别:
Expanding xenosurveillance capabilities in central America
扩大中美洲的异种监视能力
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10041581 - 财政年份:2020
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10680171 - 财政年份:2018
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Emergence of tick borne encephalitis in North America
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$ 18.55万 - 项目类别:
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