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Expanding xenosurveillance capabilities in central America

扩大中美洲的异种监视能力

基本信息

批准号：
10189517
负责人：
Gregory David Ebel
金额：
$ 18.55万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-11 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10189517
关键词：
Ache Affect Africa Americas Anger Animals Bite Blood Blood capillaries Blood specimen Central America Child Clinical Data Clinical Medicine Communicable Diseases Communities Culicidae Data Detection Devices Disease Domestic Animals Ebola virus Emerging Communicable Diseases Enrollment Entomology Environment Epidemic Exanthema Fever Frequencies Guatemala Hate Health Home Hour Household Human Laboratories Laboratory Study Latin America Methodology Methods Middle East Middle East Respiratory Syndrome Coronavirus Midgut Mind Monitor Needles Pain Paper Pathogen detection Performance Pilot Projects Population Process Public Health Quantitative Reverse Transcriptase PCR RNA Reporting Resources Rural Sampling Site Spottings Symptoms Syndrome System Temperature Time Validation Venipunctures Venous blood sampling Veterinarians Veterinary Medicine Viral Visiting Nurse Work Yellow fever virus Zoonoses base burden of illness cohort design detection limit emerging pathogen field study health economics innovation insight member minimally invasive multidisciplinary next generation sequencing pandemic disease pathogen poor communities prospective surveillance data syndromic surveillance tool transmission process virology

项目摘要

This proposal is for an R21, Expanding xenosurveillance capabilities in Central America. The project is a highly multidisciplinary effort that includes collaborators with expertise in virology, public health entomology, surveillance, and human clinical and veterinary medicine. Our study is based on the idea that mosquitoes can serve as surveillance tools because they are essentially autonomous blood sampling devices. Freshly fed mosquitoes are collected from within dwellings and blood is used for surveillance purposes. If successful, our work would have the impact of simplifying certain types of surveillance that require human blood because although most people hate it when they and their children are stuck with needles, they don’t seem to mind mosquitoes being removed from within their homes. In addition, our approach has the potential to make sampling from animals safer by vastly reducing the need for direct contact with fearful and angry animals that bite, kick, etc.. Aim 1 focuses on validating xenosurveillance through a direct comparison to human-based syndromic surveillance. Aim 2 is designed to maintain the scientific rigor of our work by obtaining quantitative estimates of the sensitivity of Cx. quinquefasciatus and Ae. aegypti for xenosurveillance. This proposal leverages significant prior work on xenosurveillance that has focused on An. gambiae in W. Africa, and an ongoing pilot study of xenosurveillance in rural Guatemala.

该提案是关于R21的，旨在扩大中美洲的异种监视能力。这个项目是一个高度