Emergence of tick borne encephalitis in North America

北美出现蜱传脑炎

基本信息

  • 批准号:
    10063475
  • 负责人:
  • 金额:
    $ 49.96万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-12-12 至 2023-11-30
  • 项目状态:
    已结题

项目摘要

Lyme disease was once restricted to coastal North Atlantic and selected Upper Midwest communities, but the distribution and prevalence of this zoonosis has greatly expanded in the last two decades. The aggressively human biting deer tick vector of the agent of Lyme disease was first recognized to maintain a distinct lineage of Powassan virus (POW) in 1997, but human encephalitis cases attributable to “deer tick virus” was recognized only in 2006. Severe neurologic disease, a hallmark of classical Powassan fever, remained rare in residents of Lyme-endemic sites until recently. Encephalitis cases attributed to Powassan virus are now being increasingly reported from New England and the upper Midwest. The biological basis for the recent zoonotic emergence of POW requires analysis. The Eurasian tick borne encephalitis virus complex (TBEV) comprises diverse species (including POW), subtypes and geographic isolates that vary in their capacity to cause human disease, and there is a rich literature concerning variation in the genetic, phenotypic and clinical characteristics of Eurasian TBEV that should guide our analysis of the potential public health burden of POW in North America. Our overaraching hypothesis is that Powassan virus, like TBEV, also comprises lineages, genotypes, or populations that differ in capacity to cause human disease. We propose to test this hypothesis using our existing geographic isolates of POW as well as additional isolates that we shall collect for their capacity to cause neurologic disease using a published mouse model for TBEV neurotropism. In addition, it may be that certain lineages, genotypes, or populations of POW are more efficiently transmitted by the human biting deer tick vector of Lyme disease, and this helps to explain the emerging epidemiological situation. Accordingly, we shall also determine whether geographic isolates may differ in their capacity to infect and be transmitted by ticks. Finally, we shall apply the powerful tools of whole genome sequencing to analyze the population structure of Powassan virus as well as identify any genetic correlates of neurotropic capacity. Taken together, these observations may help explain the changing epidemiology of an arbovirus that has been silently enzootic for over 2 decades in Lyme disease endemic sites, but is now apparently an emerging zoonosis. Ultimately, by describing the pathobiological correlates of Powassan genetic diversity, we can better define the potential for tick borne encephalitis to continue to emerge as a public health burden in North America.
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项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Gregory David Ebel其他文献

Gregory David Ebel的其他文献

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{{ truncateString('Gregory David Ebel', 18)}}的其他基金

Arbovirus population biology: temperature impacts on selection and collective dynamics
虫媒病毒种群生物学:温度对选择和集体动态的影响
  • 批准号:
    10568405
  • 财政年份:
    2023
  • 资助金额:
    $ 49.96万
  • 项目类别:
Establishment of the Bat Resource Center for the Study of Zoonotic Diseases
建立人畜共患疾病研究蝙蝠资源中心
  • 批准号:
    10374306
  • 财政年份:
    2021
  • 资助金额:
    $ 49.96万
  • 项目类别:
Expanding xenosurveillance capabilities in central America
扩大中美洲的异种监视能力
  • 批准号:
    10041581
  • 财政年份:
    2020
  • 资助金额:
    $ 49.96万
  • 项目类别:
Expanding xenosurveillance capabilities in central America
扩大中美洲的异种监视能力
  • 批准号:
    10189517
  • 财政年份:
    2020
  • 资助金额:
    $ 49.96万
  • 项目类别:
Emergence of tick borne encephalitis in North America
北美出现蜱传脑炎
  • 批准号:
    10312001
  • 财政年份:
    2018
  • 资助金额:
    $ 49.96万
  • 项目类别:
Emergence of tick borne encephalitis in North America
北美出现蜱传脑炎
  • 批准号:
    10680171
  • 财政年份:
    2018
  • 资助金额:
    $ 49.96万
  • 项目类别:
Emergence of tick borne encephalitis in North America
北美出现蜱传脑炎
  • 批准号:
    10526290
  • 财政年份:
    2018
  • 资助金额:
    $ 49.96万
  • 项目类别:
Role of cell tropism for Zika virus transmission and pathogenesis
细胞向性在寨卡病毒传播和发病机制中的作用
  • 批准号:
    9268283
  • 财政年份:
    2017
  • 资助金额:
    $ 49.96万
  • 项目类别:
Predicting genetic determinants of Zika virus emergence
预测寨卡病毒出现的遗传决定因素
  • 批准号:
    9284379
  • 财政年份:
    2016
  • 资助金额:
    $ 49.96万
  • 项目类别:
Quasispecies dynamics in arborvirus persistence, emergence and fitness
虫媒病毒持久性、出现和适应性的准种动态
  • 批准号:
    7418914
  • 财政年份:
    2007
  • 资助金额:
    $ 49.96万
  • 项目类别:

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金霉素治疗时机对成年牛无形体病治疗持续时间的评价
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    23406012
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粒细胞无形体病中中性粒细胞运输的动态
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Immunity directed against MSP 2 during anaplasmosis
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无形体病期间针对 MSP 2 的免疫
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