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Intergenerational effects of America's opioid crisis: Parental drug use and offspring health

美国阿片类药物危机的代际影响：父母吸毒与后代健康

基本信息

批准号：
10192692
负责人：
Angelica Meinhofer
金额：
$ 17.95万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10192692
关键词：
Address Adolescence Adolescent Behavior Adult Affect Age Algorithms Americas Angelica Behavioral Biostatistical Methods Birth Caring Case Management Cessation of life Characteristics Child Child Care Child Health Child Health Services Child Welfare Childhood Chronic Cohort Studies Communicable Diseases Country Data Data Linkages Data Set Development Domestic Violence Drug usage Early Intervention Economic Policy Educational workshop Elderly Epidemiologic Methods Epidemiology Evaluation Exhibits Exposure to Family Foundations Funding Goals Health Health system Imprisonment Injury Institutionalization Interdisciplinary Study Knowledge Lead Life Life Cycle Stages Light Link Literature Longitudinal Studies Medicaid Mental Health Mental disorders Mentored Research Scientist Development Award Mentors Mentorship Methods Morbidity - disease rate Mothers Nature Neonatal Abstinence Syndrome Newborn Infant Opioid Outcome Overdose Parents Pharmaceutical Preparations Poisoning Policies Population Study Pregnancy Pregnant Women Prevention Problem behavior Process Provider Research Research Design Research Personnel Residential Treatment Resources Sampling Scoring Method Services Survival Analysis System Time Training Training Activity Transportation Trauma United States Vulnerable Populations adverse childhood events algorithm training behavioral health care outcomes career child services clinical practice complex data data management design development policy early childhood early life adversity early life exposure early onset experience fetal foster care health care service utilization health economics heroin use illicit opioid improved in utero indexing intergenerational maltreatment middle childhood mortality multilevel analysis neonatal health offspring opioid epidemic opioid exposure opioid use opioid use disorder pediatric trauma perinatal period physical conditioning population based prenatal exposure prescription opioid prescription opioid misuse programs screening skills socioeconomics substance abuse treatment substance use theories traumatic event

项目摘要

PROJECT SUMMARY/ABSTRACT The burden of America's opioid crisis has heavily fallen on children, a vulnerable population increasingly exposed to opioids in utero or childhood through parental opioid use (POU). POU exposure in utero may lead to a newborn experiencing neonatal opioid withdrawal syndrome, while POU exposure in childhood may lead to a child experiencing maltreatment and family separation due to parental drug overdose mortality, parental institutionalization, or foster care placement. Life course theory postulates that early life adversity, especially in utero and early childhood, may lead to lifelong physical and mental health, substance use, behavioral, and socioeconomic problems. This K01 Mentored Research Scientist Development Award application proposes a training and research plan that will support Dr. Angélica Meinhofer on a path towards independence, focused on elucidating the impact of exposure to POU in early life (in utero up to age 8) on mental health disorders, chronic conditions, infectious diseases, injuries, and healthcare utilization in early and middle childhood. The training plan supplements Dr. Meinhofer's prior expertise in opioid use disorders, health economics, and policy evaluation with training in (1) child health with a life course perspective, (2) behavioral health systems and services for children and families, (3) epidemiology and biostatistics methods, and (4) complex data management and linkage algorithms. Dr. Meinhofer will achieve the proposed training objectives with a combination of formal coursework, workshops, and hands-on experience, as well as the mentorship of Dr. Bruce Schackman, Dr. Yuhua Bao, Dr. Katherine Keyes, and Dr. Rachel Dunifon. Drawing from the Medicaid Analytic eXtract (MAX) linked with other datasets and combining a longitudinal, population-based study design with difference-in-differences and propensity score methods, Dr. Meinhofer will use the knowledge and skills acquired through these training activities to achieve the following aims: (1) Estimate the association between exposure to opioids in utero and physical and mental health, and healthcare utilization in early childhood; (2) Estimate the association between exposure to parental drug overdose mortality in early childhood and physical and mental health, injuries, and healthcare utilization in early and middle childhood; and (3) Estimate the association between exposure to parental opioid use disorders medication treatment in early childhood and physical and mental health, injuries, and healthcare utilization in early and middle childhood. Understanding how early life exposure to POU may affect offspring outcomes over the life course provides a strong foundation upon which clinicians and policymakers can design a more proactive, coordinated, family-centered, and overall more effective agenda. The proposed K01 Award will provide Dr. Meinhofer with the resources, training, and mentoring needed to become an R01-funded independent investigator leading a multidisciplinary research program to inform policies for improving the wellbeing of children and families affected by parental substance use.

项目总结/文摘