SPARED Center

摘要：管理核心 西尔维奥·O·孔特应激肽高级研究、教育和传播中心(备用)： McLean医院将创建一个创新的、多学科的和综合的研究计划 临床前和临床部分，以阐明无节制应激引发精神疾病的机制 生病了。这5个主题相关的项目将集中在促肾上腺皮质激素释放因子(CRF)之间的相互作用。 和PACAP(垂体腺苷环化酶激活多肽)，与应激反应有关的多肽 以及包括创伤后应激障碍在内的令人衰弱的疾病的发展。为了支持这项研究任务，行政部门 CORE将维持必要的组织结构，以实现成功的沟通、整合 以及备用中心项目之间的合作，提供频繁更新的机制，并确保 有效分配和利用资源，以最大限度地发挥协同作用和科学进步。《核心》 还将支持所需的教育和培训活动，以培养麦克莱恩的未来研究人员，国家 作为哈佛医学院首屈一指的精神病学教学医院。《核心》的联合导演将是 威廉·卡莱松博士和克里·雷斯勒博士，医学博士，博士，并有4个具体目标。对于目标1，核心将 协调、整合和推进中心研究，负责5个项目的总体协调 由备用中心组成的研究小组，并指导教育、培训、外联和统计 组件。核心领导人将直接与教育、培训和外联倡议的主任合作 和统计/数据管理组件。对于目标2，核心将创建和维护一个备用中心 中心的网站，并在社交媒体上建立存在，这样我们的工作将具有全球影响力。 核心将利用这些资源向科学家和医疗保健的目标受众传播我们的工作 从业者、学生(K-12、大学、医学院和研究生)、教育工作者、NIMH“外展” 合作伙伴“，以及普通大众。对于AIM 3，核心将提供多种职业发展机会 从事与中心相关研究的早期科学家，包括种子补助金和旅行奖。 此外，我们将为教职员工和国际压力领袖组织一个备用中心研讨会，以介绍 他们的作品。我们还将鼓励备用中心的教职员工向相关科学机构提交研讨会建议 会议(如SFN、ACNP、SOBP)，并提供支持发展和教学的教育平台 新课程。对于目标4，核心将与更大的社区分享我们的集体热情和专业知识 通过外展。我们的外展任务将侧重于针对公众和学生(K-12和 学院)，通过继续我们与波士顿科学博物馆的持续合作，并开发出一种新的 通过派遣多余的中心教职员工进行研究演讲，与地区文科大学建立外展渠道， 与学生见面，并招募未来的调查人员。因此，核心将支持研究任务，同时 加强职业发展，最大限度地发挥工作对专家和非专业人员的影响。

SUMMARY: ADMINISTRATIVE CORE The Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital will create an innovative, multidisciplinary, and comprehensive research program combining preclinical and clinical components to elucidate mechanisms by which unregulated stress triggers psychiatric illness. The 5 thematically-linked projects will focus on interactions between CRF (corticotropin-releasing factor) and PACAP (pituitary adenylate cyclase activating polypeptide), peptides implicated in stress responsiveness and development of debilitating illnesses including PTSD. To support this research mission, the Administrative Core will maintain the organizational structure necessary for enabling successful communication, integration, and cooperation among SPARED Center projects, providing a mechanism for frequent updating, and ensuring effective allocation and utilization of resources for maximizing synergy and scientific advancement. The Core will also support the education and training activities needed to develop future researchers at McLean, a national leader as the premier psychiatric teaching hospital of Harvard Medical School. The Core will be Co-Directed by William Carlezon, Ph.D. and Kerry Ressler, M.D., Ph.D. and has 4 Specific Aims. For Aim 1, the Core will coordinate, integrate, and advance Center research, taking responsibility for the overall coordination of 5 research groups comprising the SPARED Center, and direct the Education, Training, Outreach, and Statistics components. Core Leaders will work directly with the directors of the Education, Training, and Outreach initiative and Statistics/Data Management component. For Aim 2, the Core will create and maintain a SPARED Center website devoted to the Center and establish a social media presence so that our work will have a global reach. The Core will use these resources to disseminate our work to target audiences of scientists and health care practitioners, students (K-12, college, medical school, and graduate students), educators, NIMH “Outreach Partners”, and the general lay-public. For Aim 3, the Core will provide multiple career-building opportunities for early-career scientists conducting SPARED Center-related research, including Seed Grants and Travel Awards. In addition, we will organize a SPARED Center Symposium for faculty and international stress leaders to present their work. We will also encourage SPARED Center faculty to submit symposia proposals to relevant scientific meetings (e.g., SfN, ACNP, SOBP) and provide an educational platform that supports development and teaching new courses. For Aim 4, the Core will share our collective enthusiasm and expertise with the larger community through outreach. Our outreach mission will focus on initiatives aimed at the public and students (K-12 and college), by continuing our ongoing collaboration with the Boston Museum of Science and developing a new outreach pipeline with regional liberal arts colleges by sending SPARED Center faculty to give research talks, meet with students, and recruit future investigators. Thus the Core will support the research mission while enhancing career development and maximizing the impact of the work for experts and lay-persons.