SPARED Center

幸免中心

• 批准号: 10116476
• 负责人: William A. Carlezon
• 金额: $ 38.78万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10116476
• 关键词: Area; Arts; Autopsy; Award; Behavioral Mechanisms; Biological Psychiatry; Boston; Clinical; Clinical Research; Collaborations; Communication; Communities; Complement; Corticotropin-Releasing Hormone; Country; Development; Doctor of Medicine; Doctor of Philosophy; Education; Education and Outreach; Educational process of instructing; Ensure; Facebook; Faculty; Fellowship; Future; Grant; Healthcare; Hospitals; International; Intranet; Leadership; Link; Major Depressive Disorder; Mental disorders; Methods; Mission; Molecular Genetics; National Institute of Mental Health; Neurosciences; Patients; Peptides; Persons; Physiological; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Research; Research Personnel; Research Support; Resources; Science; Scientist; Seeds; Senior Scientist; Site; Societies; Stress; Student recruitment; Students; Teaching Hospitals; Training; Training Activity; Training and Education; Travel; Twitter; Update; Work; brain tissue; career; career development; college; data management; educational atmosphere; graduate student; innovation; medical schools; meetings; member; multidisciplinary; news; organizational structure; outreach; pituitary adenylate cyclase activating polypeptide; pre-clinical; preclinical study; programs; science museum; senior faculty; social media; statistics; symposium; synergism; web site

SUMMARY: ADMINISTRATIVE CORE The Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital will create an innovative, multidisciplinary, and comprehensive research program combining preclinical and clinical components to elucidate mechanisms by which unregulated stress triggers psychiatric illness. The 5 thematically-linked projects will focus on interactions between CRF (corticotropin-releasing factor) and PACAP (pituitary adenylate cyclase activating polypeptide), peptides implicated in stress responsiveness and development of debilitating illnesses including PTSD. To support this research mission, the Administrative Core will maintain the organizational structure necessary for enabling successful communication, integration, and cooperation among SPARED Center projects, providing a mechanism for frequent updating, and ensuring effective allocation and utilization of resources for maximizing synergy and scientific advancement. The Core will also support the education and training activities needed to develop future researchers at McLean, a national leader as the premier psychiatric teaching hospital of Harvard Medical School. The Core will be Co-Directed by William Carlezon, Ph.D. and Kerry Ressler, M.D., Ph.D. and has 4 Specific Aims. For Aim 1, the Core will coordinate, integrate, and advance Center research, taking responsibility for the overall coordination of 5 research groups comprising the SPARED Center, and direct the Education, Training, Outreach, and Statistics components. Core Leaders will work directly with the directors of the Education, Training, and Outreach initiative and Statistics/Data Management component. For Aim 2, the Core will create and maintain a SPARED Center website devoted to the Center and establish a social media presence so that our work will have a global reach. The Core will use these resources to disseminate our work to target audiences of scientists and health care practitioners, students (K-12, college, medical school, and graduate students), educators, NIMH “Outreach Partners”, and the general lay-public. For Aim 3, the Core will provide multiple career-building opportunities for early-career scientists conducting SPARED Center-related research, including Seed Grants and Travel Awards. In addition, we will organize a SPARED Center Symposium for faculty and international stress leaders to present their work. We will also encourage SPARED Center faculty to submit symposia proposals to relevant scientific meetings (e.g., SfN, ACNP, SOBP) and provide an educational platform that supports development and teaching new courses. For Aim 4, the Core will share our collective enthusiasm and expertise with the larger community through outreach. Our outreach mission will focus on initiatives aimed at the public and students (K-12 and college), by continuing our ongoing collaboration with the Boston Museum of Science and developing a new outreach pipeline with regional liberal arts colleges by sending SPARED Center faculty to give research talks, meet with students, and recruit future investigators. Thus the Core will support the research mission while enhancing career development and maximizing the impact of the work for experts and lay-persons.

摘要：行政核心 Silvio O. Conte Center for Stress Peptide Advanced Research，Education，& Dissemination（英语：Conte Center for Stress Peptide Advanced Research，Education，& Dissemination） 姆克林医院将创建一个创新的，多学科的，全面的研究计划，结合 临床前和临床组成部分，以阐明机制，其中不受管制的压力触发精神 病这5个主题相关的项目将侧重于CRF（促肾上腺皮质激素释放因子） 和PACAP（垂体腺苷酸环化酶激活多肽），涉及应激反应的肽 以及包括创伤后应激障碍在内的衰弱性疾病的发展。为了支持这项研究使命， 核心将保持必要的组织结构，以实现成功的沟通，整合， 以及SPARED中心项目之间的合作，提供频繁更新的机制，并确保 有效分配和利用资源，以实现最大限度的协同增效和科学进步。核心 还将支持教育和培训活动所需的发展未来的研究人员在姆克林，一个国家 作为哈佛医学院首屈一指的精神病学教学医院的领导者。核心将由 William Carlezon博士和Kerry Ressler医学博士博士有四个具体目标。对于目标1，核心将 协调、整合和推进中心研究，负责5个项目的总体协调 研究小组组成的SPARED中心，并直接教育，培训，推广，和统计 件.核心领导人将直接与教育、培训和外联活动的负责人合作 统计/数据管理部分。对于目标2，核心将创建并维护备用中心 该中心还将设立一个专门介绍该中心的网站，并建立一个社交媒体平台，以便我们的工作能够覆盖全球。 核心将利用这些资源向科学家和卫生保健目标受众传播我们的工作 从业人员，学生（K-12，大学，医学院和研究生），教育工作者，NIMH“外展 “合作伙伴”，以及普通大众。就目标3而言，核心计划将为以下人士提供多种职业发展机会： 从事SPARED中心相关研究的早期职业科学家，包括种子赠款和旅行奖。 此外，我们将组织一个备用中心研讨会的教师和国际压力领导人提出 他们的工作。我们还将鼓励SPARED中心的教师向相关科学机构提交专题讨论会提案， 会议（例如，SfN、ACNP、SOBP），并提供支持发展和教学的教育平台 新课程。对于目标4，核心将与广大社区分享我们的集体热情和专业知识 通过外展。我们的外展使命将侧重于针对公众和学生（K-12和 学院），通过继续我们与波士顿科学博物馆的持续合作， 通过派遣SPARED中心的教师进行研究讲座， 与学生会面，并招募未来的调查人员。因此，核心将支持研究使命， 加强职业发展，最大限度地扩大专家和非专业人员的工作影响。