SPARED Center

幸免中心

• 批准号: 10116476
• 负责人: William A. Carlezon
• 金额: $ 38.78万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10116476
• 关键词: Area; Arts; Autopsy; Award; Behavioral Mechanisms; Biological Psychiatry; Boston; Clinical; Clinical Research; Collaborations; Communication; Communities; Complement; Corticotropin-Releasing Hormone; Country; Development; Doctor of Medicine; Doctor of Philosophy; Education; Education and Outreach; Educational process of instructing; Ensure; Facebook; Faculty; Fellowship; Future; Grant; Healthcare; Hospitals; International; Intranet; Leadership; Link; Major Depressive Disorder; Mental disorders; Methods; Mission; Molecular Genetics; National Institute of Mental Health; Neurosciences; Patients; Peptides; Persons; Physiological; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Research; Research Personnel; Research Support; Resources; Science; Scientist; Seeds; Senior Scientist; Site; Societies; Stress; Student recruitment; Students; Teaching Hospitals; Training; Training Activity; Training and Education; Travel; Twitter; Update; Work; brain tissue; career; career development; college; data management; educational atmosphere; graduate student; innovation; medical schools; meetings; member; multidisciplinary; news; organizational structure; outreach; pituitary adenylate cyclase activating polypeptide; pre-clinical; preclinical study; programs; science museum; senior faculty; social media; statistics; symposium; synergism; web site

SUMMARY: ADMINISTRATIVE CORE The Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital will create an innovative, multidisciplinary, and comprehensive research program combining preclinical and clinical components to elucidate mechanisms by which unregulated stress triggers psychiatric illness. The 5 thematically-linked projects will focus on interactions between CRF (corticotropin-releasing factor) and PACAP (pituitary adenylate cyclase activating polypeptide), peptides implicated in stress responsiveness and development of debilitating illnesses including PTSD. To support this research mission, the Administrative Core will maintain the organizational structure necessary for enabling successful communication, integration, and cooperation among SPARED Center projects, providing a mechanism for frequent updating, and ensuring effective allocation and utilization of resources for maximizing synergy and scientific advancement. The Core will also support the education and training activities needed to develop future researchers at McLean, a national leader as the premier psychiatric teaching hospital of Harvard Medical School. The Core will be Co-Directed by William Carlezon, Ph.D. and Kerry Ressler, M.D., Ph.D. and has 4 Specific Aims. For Aim 1, the Core will coordinate, integrate, and advance Center research, taking responsibility for the overall coordination of 5 research groups comprising the SPARED Center, and direct the Education, Training, Outreach, and Statistics components. Core Leaders will work directly with the directors of the Education, Training, and Outreach initiative and Statistics/Data Management component. For Aim 2, the Core will create and maintain a SPARED Center website devoted to the Center and establish a social media presence so that our work will have a global reach. The Core will use these resources to disseminate our work to target audiences of scientists and health care practitioners, students (K-12, college, medical school, and graduate students), educators, NIMH “Outreach Partners”, and the general lay-public. For Aim 3, the Core will provide multiple career-building opportunities for early-career scientists conducting SPARED Center-related research, including Seed Grants and Travel Awards. In addition, we will organize a SPARED Center Symposium for faculty and international stress leaders to present their work. We will also encourage SPARED Center faculty to submit symposia proposals to relevant scientific meetings (e.g., SfN, ACNP, SOBP) and provide an educational platform that supports development and teaching new courses. For Aim 4, the Core will share our collective enthusiasm and expertise with the larger community through outreach. Our outreach mission will focus on initiatives aimed at the public and students (K-12 and college), by continuing our ongoing collaboration with the Boston Museum of Science and developing a new outreach pipeline with regional liberal arts colleges by sending SPARED Center faculty to give research talks, meet with students, and recruit future investigators. Thus the Core will support the research mission while enhancing career development and maximizing the impact of the work for experts and lay-persons.

摘要：行政核心 Silvio O. Conte 应激肽高级研究、教育和传播中心 (SPARED)，位于 麦克莱恩医院将创建一个创新的、多学科的、综合性的研究项目，结合 临床前和临床组成部分，以阐明不受调节的压力引发精神病的机制 疾病。 5 个主题相关的项目将重点关注 CRF（促肾上腺皮质激素释放因子）之间的相互作用 和 PACAP（垂体腺苷酸环化酶激活多肽），与应激反应有关的肽 以及包括创伤后应激障碍（PTSD）在内的衰弱性疾病的发展。为了支持这项研究任务，行政 核心将维持必要的组织结构，以实现成功的沟通、整合、 以及SPARED中心项目之间的合作，提供频繁更新的机制，并确保 有效配置和利用资源，最大限度地发挥协同作用和科学进步。核心 还将支持麦克莱恩国家实验室培养未来研究人员所需的教育和培训活动 作为哈佛医学院首屈一指的精神病学教学医院的领导者。核心将由以下人员共同领导 William Carlezon, Ph.D.和 Kerry Ressler，医学博士、哲学博士并有 4 个具体目标。 For Aim 1, the Core will 协调、整合、推进中心研究工作，负责5个部门的总体协调 由 SPARED 中心组成的研究小组，指导教育、培训、外展和统计 成分。核心领导者将直接与教育、培训和外展计划的负责人合作 和统计/数据管理组件。对于目标 2，核心将创建并维护一个 SPARED 中心 专门介绍该中心的网站并建立社交媒体，以便我们的工作能够覆盖全球。 核心将利用这些资源向科学家和医疗保健目标受众传播我们的工作 从业者、学生（K-12、大学、医学院和研究生）、教育工作者、NIMH“外展” 合作伙伴”和普通大众。对于目标 3，核心将为他们提供多种职业建设机会 从事 SPARED 中心相关研究的早期职业科学家，包括种子补助金和旅行奖。 此外，我们将为教师和国际压力领导者组织一场 SPARED 中心研讨会 their work.我们还将鼓励 SPARED 中心的教师向相关科学界提交研讨会提案 会议（例如 SfN、ACNP、SOBP）并提供支持发展和教学的教育平台 new courses.对于目标 4，核心将与更大的社区分享我们的集体热情和专业知识 through outreach.我们的外展任务将重点关注针对公众和学生（K-12 和 学院），通过继续与波士顿科学博物馆持续合作并开发一个新的 通过派遣 SPARED 中心教员进行研究讲座，与地区文理学院建立外展渠道， 与学生见面，并招募未来的调查员。因此，核心将支持研究任务，同时 促进专家和非专业人士的职业发展并最大限度地发挥工作的影响。