Glucose patterns and cardiac arrhythmias in older adults with diabetes

摘要 2型糖尿病和心律失常在老年人中都非常普遍。越来越多的人意识到 糖尿病会影响心脏的传导系统。无症状的心律失常被认为是 在老年人中尤其常见，尤其是在糖尿病的情况下。这些心律失常中的许多是 被认为是有害的，但它们对老年糖尿病患者的心血管结局和死亡率的影响 目前还不清楚。先前的研究表明，糖尿病患者的血糖变异性和低血糖有助于 房性和室性心律失常的高负荷。然而，以前的研究并没有收集到伴随的 关于血糖模式和心电记录的信息。我们认为血糖升高的模式(低血糖、高血糖和 可变葡萄糖)可能是糖尿病患者心律失常的重要原因。为了解决这个问题，我们将 在成人糖尿病患者中进行连续血糖监测和无铅“贴片”心电监测 研究对象为60岁及以上的糖尿病患者，以评估血糖和心率的同步变化。我们会 将这些模式与当前的健康状况和长期临床结果联系起来。我们的研究将为这个角色提供信息 低血糖、高血糖和可变血糖导致老年人心律失常和随后的结局 患有糖尿病。

Abstract Type 2 diabetes and cardiac arrhythmias are both highly prevalent in older age. There is growing awareness that diabetes affects the electrical conduction system in the heart. Asymptomatic arrhythmias are thought to be particularly common in older adults, especially in the setting of diabetes. Many of these arrhythmias are thought to be harmful, but their impact on cardiovascular outcomes and mortality in older adults with diabetes is not clear. Prior research has shown that glycemic variability and hypoglycemia in diabetes contribute to a high burden of atrial and ventricular arrhythmias. However, prior studies have not collected concomitant information on glucose patterns and ECG recordings. We contend the glycemic patterns (low, high, and variable glucose) may acutely contribute to cardiac arrhythmias in diabetes. To address this question, we will conduct continuous glucose monitoring and leadless “patch” ECG monitoring in a population of adults with diabetes aged 60 years and older to assess coinciding variations in glycemia and cardiac rhythm. We will relate these patterns to current health status and long-term clinical outcomes. Our research will inform the role of low, high, and variable glucose in leading to cardiac arrhythmias and subsequent outcomes in older adults with diabetes.