Glucose patterns and cardiac arrhythmias in older adults with diabetes

老年糖尿病患者的血糖模式和心律失常

• 批准号: 10360749
• 负责人: Lin Yee Chen
• 金额: $ 76.77万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10360749
• 关键词: Acute; Address; Adult; Affect; Age; Arrhythmia; Atherosclerosis Risk in Communities; Atrial Fibrillation; Atrial Premature Complexes; Atrial Tachycardia; Awareness; Cardiac; Cardiovascular system; Cessation of life; Clinical; Clinical Data; Cognitive; Communities; Data; Diabetes Mellitus; Diagnosis; Disease; Elderly; Electrocardiogram; Event; Frequencies; Glucose; Glycosylated hemoglobin A; Goals; Health; Health Status; Heart; Heart Atrium; High Prevalence; Hyperglycemia; Hypoglycemia; Impaired cognition; Impairment; International Classification of Disease Codes; Lead; Link; Measures; Mediating; Methods; Monitor; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Pattern; Pharmaceutical Preparations; Physical Function; Physical assessment; Population; Prevalence; Research; Risk Factors; Role; Sample Size; System; Technology; Testing; Variant; Ventricular Arrhythmia; Ventricular Premature Complexes; Ventricular Tachycardia; Visit; adjudicate; aged; base; cardiovascular risk factor; cognitive function; evidence base; follow-up; frailty; glucose monitor; heart rate variability; heart rhythm; monitoring device; mortality; novel; prognostic significance; prospective; recruit

Abstract Type 2 diabetes and cardiac arrhythmias are both highly prevalent in older age. There is growing awareness that diabetes affects the electrical conduction system in the heart. Asymptomatic arrhythmias are thought to be particularly common in older adults, especially in the setting of diabetes. Many of these arrhythmias are thought to be harmful, but their impact on cardiovascular outcomes and mortality in older adults with diabetes is not clear. Prior research has shown that glycemic variability and hypoglycemia in diabetes contribute to a high burden of atrial and ventricular arrhythmias. However, prior studies have not collected concomitant information on glucose patterns and ECG recordings. We contend the glycemic patterns (low, high, and variable glucose) may acutely contribute to cardiac arrhythmias in diabetes. To address this question, we will conduct continuous glucose monitoring and leadless “patch” ECG monitoring in a population of adults with diabetes aged 60 years and older to assess coinciding variations in glycemia and cardiac rhythm. We will relate these patterns to current health status and long-term clinical outcomes. Our research will inform the role of low, high, and variable glucose in leading to cardiac arrhythmias and subsequent outcomes in older adults with diabetes.

摘要 2型糖尿病和心律失常在老年人中都很普遍。人们越来越认识 糖尿病会影响心脏的电传导系统。无症状心律失常被认为是 在老年人中尤其常见，尤其是在糖尿病的情况下。许多心律失常是 被认为是有害的，但它们对老年糖尿病患者心血管结局和死亡率的影响 还不清楚。先前的研究表明，糖尿病中的血糖变异性和低血糖会导致糖尿病的发生。 房性和室性心律失常的高负担。然而，先前的研究没有收集伴随的 关于血糖模式和ECG记录的信息。我们主张血糖模式（低，高， 可变的葡萄糖）可能急性地导致糖尿病中的心律失常。为了解决这个问题，我们将 在成人人群中进行连续葡萄糖监测和无导线“贴片”ECG监测， 60岁及以上的糖尿病患者，以评估心率和心律的一致变化。我们将 将这些模式与当前健康状况和长期临床结果联系起来。我们的研究将为 老年人中低、高和可变葡萄糖导致心律失常和后续结果的关系 患有糖尿病