Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias
运动、睡眠和心律数字信号在阿尔茨海默病和相关痴呆症检测中的新应用
基本信息
- 批准号:10710169
- 负责人:
- 金额:$ 75.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-30 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerometerAddressAllelesAlzheimer disease detectionAlzheimer&aposs disease related dementiaAmyloid beta-ProteinApolipoprotein EAtherosclerosis Risk in CommunitiesAtrial FibrillationAtrial Premature ComplexesAtrial TachycardiaAtrophicBiologicalBlood VesselsBrainBrain PathologyClinicalCognitiveDataData CollectionDementiaDevelopmentDiagnosisDigital biomarkerDiseaseEarly DiagnosisElderlyElectrocardiogramEnvironmentExhibitsFree AssociationFrequenciesFutureGeneticGoalsHealthHeart AbnormalitiesImpaired cognitionIndividualInterventionJointsKnowledgeLinkMeasuresMonitorMovementMultivariate AnalysisNerve DegenerationNeurocognitiveNeuropsychologyParticipantPathologyPathway interactionsPatternPhasePhenotypePhysical FunctionPhysical activityPhysiologicalPositron-Emission TomographyPrevention trialPrincipal Component AnalysisResearchRestRiskRisk FactorsRoleSeveritiesSignal TransductionSleepSleep FragmentationsTimeVariantVentricular Premature ComplexesVentricular TachycardiaWhite Matter Diseaseabeta depositionadjudicationbrain healthbrain magnetic resonance imagingcircadianclinically relevantcognitive changecognitive functioncognitive performancecognitive testingcost effectivedementia riskdigitaldigital measuredigital technologyfightingfollow-upfunctional declineheart rate variabilityheart rhythmhigh riskimprovedindividual variationmild cognitive impairmentneuroimagingnovelpoor sleepresponsescreeningsedentarysexsleep abnormalitiessleep onsettoolwearable deviceβ-amyloid burden
项目摘要
PROJECT SUMMARY
Early detection of cognitive and functional decline is a major goal of the NIA in its fight against Alzheimer's
Disease and Related Dementias (ADRD). Physical, physiological, and cognitive changes associated with ADRD
may emerge years prior to clinical manifestations, thus there is an urgent need for novel, cost-effective,
noninvasive, and scalable tools to improve detection of ADRD risk. Older adults with cognitive impairment often
exhibit changes in movement, sleep, and heart rhythms, suggesting possible shared vascular or
neurodegenerative pathways. Emerging research from our group and others links digital signals from movement,
sleep, and heart rhythms with brain and cognitive health; however, knowledge gaps remain in the associations
among these signals and brain and cognitive health across the cognitive spectrum. In response to NOT-AG-20-
017, this application will directly address these gaps using existing and ongoing/new data collection from
wearable technology (7-day accelerometry and 14-day ambulatory electrocardiogram (ECG)), cognitive
assessments (neuropsychological battery, adjudicated cognitive diagnosis), and neuroimaging (florbetapir PET
for beta amyloid (Aβ), 3T brain MRI for neurodegeneration and white matter disease) from ≥1000 older adults
participating in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study. We will use novel analytic
approaches to integrate movement, sleep, and heart rhythm features and assess their individual and joint
associations with brain and cognitive health. Our overarching goal is to identify clinically relevant digital
biomarkers that combine movement, sleep, and heart rhythm signals as sensitive indicators of cognitive function,
cognitive trajectories, ADRD pathology, and cognitive diagnosis. To this end, this research will inform the future
use of wearable devices in large-scale studies, provide novel targets for screening and early detection of ADRD
in disease stages during which intervention and treatment are more likely to be effective, and aid in identifying
high-risk participants for prevention trials.
项目总结
早期发现认知和功能衰退是NIA对抗阿尔茨海默氏症的主要目标
疾病及相关痴呆(ADRD)。与ADRD相关的身体、生理和认知变化
可能出现在临床症状之前数年,因此迫切需要新颖、经济、
非侵入性、可扩展的工具,可改进ADRD风险检测。患有认知障碍的老年人经常
表现出运动、睡眠和心率的变化,提示可能有共同的血管或
神经退行性变的途径。我们团队和其他人的新研究将运动产生的数字信号联系起来,
睡眠、心跳节律与大脑和认知健康;然而,知识差距仍然存在
在这些信号中,大脑和认知健康贯穿认知光谱。回应NOT-AG-20-
017,该应用程序将使用现有的和正在进行的/新的数据收集直接解决这些差距
可穿戴技术(7天加速测量和14天动态心电图),认知
评估(神经心理成套测验、已判定的认知诊断)和神经成像(氟倍他匹PET
对于β淀粉样蛋白(Aβ),3T脑核磁共振用于神经退行性变和白质疾病)来自≥1000老年人
参与社区动脉粥样硬化风险(ARIC)神经认知研究。我们将使用新的分析
综合运动、睡眠和心率特征并评估其个体和关节的方法
与大脑和认知健康的关系。我们的首要目标是识别与临床相关的数字
结合运动、睡眠和心率信号的生物标志物,作为认知功能的敏感指标,
认知轨迹、ADRD病理学和认知诊断。为此,这项研究将为未来提供信息
可穿戴设备在大规模研究中的使用,为ADRD的筛查和早期检测提供了新的靶点
在干预和治疗更有可能有效的疾病阶段,并帮助确定
预防试验的高危参与者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lin Yee Chen其他文献
PO-668-03 GREATER CENTRAL ADIPOSITY IS ASSOCIATED WITH POORER LEFT ATRIAL FUNCTION: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
PO-668-03 中心性肥胖程度较高与左心房功能较差相关:社区动脉粥样硬化风险(ARIC)研究
- DOI:
10.1016/j.hrthm.2022.03.389 - 发表时间:
2022-05-01 - 期刊:
- 影响因子:5.700
- 作者:
Joseph John Decker;Romil Parikh;Michael Jingyuan Zhang;Alvaro Alonso;Scott D. Solomon;Jeremy Van't Hof;Lin Yee Chen - 通讯作者:
Lin Yee Chen
PO-02-088 FREQUENCY OF EARLY REPOLARIZATION PATTERN AND RISK OF SUDDEN CARDIAC DEATH
PO-02-088 早期复极图形的频率与心脏性猝死的风险
- DOI:
10.1016/j.hrthm.2024.03.820 - 发表时间:
2024-05-01 - 期刊:
- 影响因子:5.700
- 作者:
Daniel Matasic;Rachit M. Vakil;Chukwuka Ibecheozor;Elsayed Z. Soliman;Lin Yee Chen;Michael Hall;Nona Sotoodehnia;Wayne Rosamond;Kunihiro Matsushita;Chiadi Ndumele;Jonathan Chrispin - 通讯作者:
Jonathan Chrispin
Chest Symptoms and Long-Term Risk of Incident Cardiovascular Disease
- DOI:
10.1016/j.amjmed.2024.07.009 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:
- 作者:
Kentaro Ejiri;Yejin Mok;Ning Ding;Patricia P. Chang;Wayne D. Rosamond;Amil M. Shah;Pamela L. Lutsey;Lin Yee Chen;Michael J. Blaha;Lena Mathews;Kunihiro Matsushita - 通讯作者:
Kunihiro Matsushita
ASSOCIATION OF SILENT MYOCARDIAL INFARCTION WITH COGNITIVE DECLINE OVER 25 YEARS: RESULTS FROM THE ARIC-NCS (ATHEROSCLEROSIS RISK IN COMMUNITIES NEUROCOGNITIVE STUDY)
25 年以上沉默型心肌梗死与认知功能下降的关联:来自 ARIC-NCS(社区动脉粥样硬化风险神经认知研究)的结果
- DOI:
10.1016/s0735-1097(25)02367-8 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:22.300
- 作者:
Mohamed A. Mostafa;Christopher Schaich;Faye Norby;Richard Kazibwe;Lingyi Lu;Lin Yee Chen;Timothy Hughes;Elsayed Z. Soliman - 通讯作者:
Elsayed Z. Soliman
ECG-AI: AN EXTERNALLY VALIDATED DEEP LEARNING MODEL TO PREDICT HEART FAILURE RISK
- DOI:
10.1016/s0735-1097(22)01319-5 - 发表时间:
2022-03-08 - 期刊:
- 影响因子:
- 作者:
Oguz Akbilgic;Liam Butler;Ibrahim Karabayir;Dalane W. Kitzman;Gari Clifford;Lin Yee Chen;Alvaro Alonso;Patricia P. Chang;Elsayed Z. Soliman - 通讯作者:
Elsayed Z. Soliman
Lin Yee Chen的其他文献
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{{ truncateString('Lin Yee Chen', 18)}}的其他基金
Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related Dementias
认知障碍和痴呆、血管性脑损伤和心房肌病:对预防阿尔茨海默病相关痴呆的影响
- 批准号:
10814076 - 财政年份:2023
- 资助金额:
$ 75.32万 - 项目类别:
Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related Dementias
西班牙裔/拉丁裔的认知衰老、大脑形态和心律失常:对预防和管理阿尔茨海默病相关痴呆的影响
- 批准号:
10448081 - 财政年份:2022
- 资助金额:
$ 75.32万 - 项目类别:
Glucose patterns and cardiac arrhythmias in older adults with diabetes
老年糖尿病患者的血糖模式和心律失常
- 批准号:
10360749 - 财政年份:2022
- 资助金额:
$ 75.32万 - 项目类别:
Glucose patterns and cardiac arrhythmias in older adults with diabetes
老年糖尿病患者的血糖模式和心律失常
- 批准号:
10597965 - 财政年份:2022
- 资助金额:
$ 75.32万 - 项目类别:
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias
运动、睡眠和心律数字信号在阿尔茨海默病和相关痴呆症检测中的新应用
- 批准号:
10525869 - 财政年份:2022
- 资助金额:
$ 75.32万 - 项目类别:
Mentoring and Research to ClassifyAtrial Cardiomyopathy
心房心肌病分类的指导和研究
- 批准号:
10439909 - 财政年份:2021
- 资助金额:
$ 75.32万 - 项目类别:
Mentoring and Research to ClassifyAtrial Cardiomyopathy
心房心肌病分类的指导和研究
- 批准号:
10640951 - 财政年份:2021
- 资助金额:
$ 75.32万 - 项目类别:
Mentoring and Research to Classify Atrial Cardiomyopathy
心房心肌病分类的指导和研究
- 批准号:
10307378 - 财政年份:2021
- 资助金额:
$ 75.32万 - 项目类别:
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
左心房异常和心房颤动相关的脑梗塞和认知能力下降
- 批准号:
9495380 - 财政年份:2018
- 资助金额:
$ 75.32万 - 项目类别:
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
左心房异常和心房颤动相关的脑梗塞和认知能力下降
- 批准号:
9900061 - 财政年份:2018
- 资助金额:
$ 75.32万 - 项目类别:
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