Mentoring and Research to ClassifyAtrial Cardiomyopathy

心房心肌病分类的指导和研究

基本信息

  • 批准号:
    10640951
  • 负责人:
  • 金额:
    $ 12.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

This K24 grant will provide the PI, Dr. Lin Yee Chen, a midcareer NIH-funded patient-oriented research (POR) investigator, with the protected time and support needed to (1) accelerate his current trajectory in mentoring junior clinicians and investigators who are conducting POR in cardiovascular (CV) science, (2) acquire additional training in mentoring methods, machine learning, and omics science, (3) promote his current research that aims to define the mechanisms underlying the relationship of the abnormal atrial substrate—atrial cardiomyopathy—and atrial fibrillation (AF) to ischemic stroke and other CV outcomes. Trainees in his AF Clinical Research Group will be recruited from the NIH-funded T32 training programs in the University of Minnesota's Division of Cardiology, Division of Epidemiology, and Division of Biostatistics; Department of Medicine Physician Scientist Training Program; KL2 and TL1 Programs of the CTSI; and graduate programs (MS in Clinical Research, MPH, and PhD) in the School of Public Health. For his career development, Dr. Chen will hone his mentoring skills and learn new skills in cutting-edge areas (machine learning and omics science) through focused study, selected coursework, seminars, and guidance from senior collaborators with domain expertise. Finally, this grant will support a research project that is based on the Atherosclerosis Risk in Communities (ARIC) Study, which extends Dr. Chen’s ongoing work to elucidate the role of atrial cardiomyopathy in driving AF-related outcomes. The specific aims are: (1) Identify atrial cardiomyopathy subtypes by using machine learning approaches to analyze the extensive data at ARIC Visit 5 (2011-13): clinical, 2D-echocardiographic, heart rate variability, arterial stiffness, ECG, and multi-omics data, (2) Evaluate association of subtypes with ischemic stroke and other CV outcomes, and (3) Discover specific risk factors for subtypes by analyzing risk factor measures collected at Visits 1-4 (1987-98). Crucially, findings will be validated in 2 independent community-based cohorts: Cardiovascular Health Study (CHS) and Multi-Ethnic Study of Atherosclerosis (MESA). This project has significant impact: (1) This K24 grant will provide the PI with the protected time to enhance his current mentoring of trainees involved in POR. By assembling a team of senior collaborators that comprise experts in mentoring, data science, and molecular epidemiology, the PI provides an outstanding platform for his mentees to acquire cutting-edge skills in POR, (2) By resolving heterogeneity in atrial cardiomyopathy, the team will advance the NIH’s Precision Medicine initiative by personalizing current treatment for patients based on biological underpinnings, (3) The findings will lead to a clinically meaningful improvement in classification of stroke risk in patients with AF, which will improve patient outcomes, (4) By efficiently leveraging existing resources of deeply phenotyped NHLBI cohorts, this project will fill critical knowledge gaps in prevention and treatment, thus achieving a sustained and powerful impact on CV public health, clinical practice, and education of the next generation of researchers in POR.
这笔 K24 拨款将为 PI Lin Yee Chen 博士提供一项由 NIH 资助的职业中期患者导向研究 (POR) 调查员,拥有所需的受保护的时间和支持(1)加速他目前的指导轨迹 在心血管 (CV) 科学领域进行 POR 的初级临床医生和研究人员,(2) 获得 指导方法、机器学习和组学科学方面的额外培训,(3) 推广他当前的 旨在明确异常心房基质——心房之间关系的潜在机制的研究 心肌病——以及心房颤动(AF)、缺血性中风和其他心血管结局。 AF 的实习生 临床研究小组将从NIH资助的大学T32培训项目中招募 明尼苏达州心脏病学部、流行病学部和生物统计学部;系 医学医师科学家培训计划; CTSI的KL2和TL1计划;和研究生课程 公共卫生学院(临床研究硕士、公共卫生硕士和博士学位)。为了他的职业发展,博士。 陈将磨练他的指导技能并学习前沿领域(机器学习和组学)的新技能 科学)通过集中学习、精选课程、研讨会以及高级合作者的指导 领域的专业知识。最后,这笔赠款将支持一个基于动脉粥样硬化风险的研究项目 社区 (ARIC) 研究,该研究扩展了陈博士正在进行的工作,以阐明心房的作用 心肌病导致 AF 相关结果。具体目标是: (1) 识别心房心肌病 通过使用机器学习方法分析 ARIC 访问 5(2011-13)中的大量数据来确定子类型: 临床、2D 超声心动图、心率变异性、动脉僵硬度、心电图和多组学数据,(2) 评估 亚型与缺血性中风和其他心血管结果的关联,以及 (3) 发现特定的危险因素 通过分析第 1-4 次访问(1987-98 年)收集的风险因素测量值来确定亚型。至关重要的是,调查结果将是 在 2 个独立的基于社区的队列中得到验证:心血管健康研究 (CHS) 和多种族 动脉粥样硬化研究(MESA)。该项目具有重大影响: (1) 这项 K24 补助金将提供 PI 用受保护的时间来加强他目前对参与 POR 的学员的指导。通过组建一个团队 由指导、数据科学和分子流行病学专家组成的高级合作者,PI 为他的学员提供了一个获得 POR 尖端技能的出色平台,(2) 通过解决 鉴于心房心肌病的异质性,该团队将通过以下方式推进 NIH 的精准医学计划: 根据生物学基础对患者当前的治疗进行个性化,(3)研究结果将导致 AF 患者卒中风险分类的临床有意义的改进,这将改善患者 (4) 通过有效利用深度表型 NHLBI 队列的现有资源,该项目将 填补预防和治疗方面的关键知识空白,从而对疾病产生持续而强大的影响 CV 公共卫生、临床实践以及下一代 POR 研究人员的教育。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Relationship Between High Blood Pressure, Atrial Cardiopathy, and Mortality in the General Population.
一般人群中高血压、心房性心脏病和死亡率之间的关系。
  • DOI:
    10.1093/ajh/hpac087
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    ImtiazAhmad,Muhammad;Mendys,PhilM;Kelly,ScottP;Chen,LinY;Soliman,ElsayedZ
  • 通讯作者:
    Soliman,ElsayedZ
Association of Right Ventricular Afterload With Atrial Fibrillation Risk in Older Adults: The Atherosclerosis Risk in Communities Study.
老年人右心室后负荷与心房颤动风险的关联:社区研究中的动脉粥样硬化风险。
  • DOI:
    10.1016/j.chest.2022.05.004
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    9.6
  • 作者:
    Parikh,RomilR;Norby,FayeL;Wang,Wendy;Thenappan,Thenappan;Prins,KurtW;Van'tHof,JeremyR;Lutsey,PamelaL;Solomon,ScottD;Shah,AmilM;Chen,LinYee
  • 通讯作者:
    Chen,LinYee
Joint Association of Albuminuria and Left Ventricular Hypertrophy with Incident Heart Failure in High-Risk Adults with Hypertension: a SPRINT substudy.
高血压高危成人中蛋白尿和左心室肥厚与心力衰竭的联合关联:一项 SPRINT 子研究。
  • DOI:
    10.1101/2023.07.06.23292329
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ahmad,MuhammadImtiaz;Kazibwe,Richard;Soliman,MaiZ;Singh,Sanjay;Chen,LinY;Soliman,ElsayedZ
  • 通讯作者:
    Soliman,ElsayedZ
Joint Association of Albuminuria and Left Ventricular Hypertrophy With Incident Heart Failure in Adults at High Risk With Hypertension: A Systolic Blood Pressure Intervention Trial Substudy.
高血压高危成人中蛋白尿和左心室肥厚与心力衰竭的联合关联:收缩压干预试验亚组研究。
  • DOI:
    10.1016/j.amjcard.2023.09.048
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ahmad,MuhammadImtiaz;Kazibwe,Richard;Soliman,MaiZ;Singh,Sanjay;Chen,LinY;Soliman,ElsayedZ
  • 通讯作者:
    Soliman,ElsayedZ
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Lin Yee Chen其他文献

PO-668-03 GREATER CENTRAL ADIPOSITY IS ASSOCIATED WITH POORER LEFT ATRIAL FUNCTION: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
PO-668-03 中心性肥胖程度较高与左心房功能较差相关:社区动脉粥样硬化风险(ARIC)研究
  • DOI:
    10.1016/j.hrthm.2022.03.389
  • 发表时间:
    2022-05-01
  • 期刊:
  • 影响因子:
    5.700
  • 作者:
    Joseph John Decker;Romil Parikh;Michael Jingyuan Zhang;Alvaro Alonso;Scott D. Solomon;Jeremy Van't Hof;Lin Yee Chen
  • 通讯作者:
    Lin Yee Chen
PO-02-088 FREQUENCY OF EARLY REPOLARIZATION PATTERN AND RISK OF SUDDEN CARDIAC DEATH
PO-02-088 早期复极图形的频率与心脏性猝死的风险
  • DOI:
    10.1016/j.hrthm.2024.03.820
  • 发表时间:
    2024-05-01
  • 期刊:
  • 影响因子:
    5.700
  • 作者:
    Daniel Matasic;Rachit M. Vakil;Chukwuka Ibecheozor;Elsayed Z. Soliman;Lin Yee Chen;Michael Hall;Nona Sotoodehnia;Wayne Rosamond;Kunihiro Matsushita;Chiadi Ndumele;Jonathan Chrispin
  • 通讯作者:
    Jonathan Chrispin
Chest Symptoms and Long-Term Risk of Incident Cardiovascular Disease
  • DOI:
    10.1016/j.amjmed.2024.07.009
  • 发表时间:
    2024-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kentaro Ejiri;Yejin Mok;Ning Ding;Patricia P. Chang;Wayne D. Rosamond;Amil M. Shah;Pamela L. Lutsey;Lin Yee Chen;Michael J. Blaha;Lena Mathews;Kunihiro Matsushita
  • 通讯作者:
    Kunihiro Matsushita
ASSOCIATION OF SILENT MYOCARDIAL INFARCTION WITH COGNITIVE DECLINE OVER 25 YEARS: RESULTS FROM THE ARIC-NCS (ATHEROSCLEROSIS RISK IN COMMUNITIES NEUROCOGNITIVE STUDY)
25 年以上沉默型心肌梗死与认知功能下降的关联:来自 ARIC-NCS(社区动脉粥样硬化风险神经认知研究)的结果
  • DOI:
    10.1016/s0735-1097(25)02367-8
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    22.300
  • 作者:
    Mohamed A. Mostafa;Christopher Schaich;Faye Norby;Richard Kazibwe;Lingyi Lu;Lin Yee Chen;Timothy Hughes;Elsayed Z. Soliman
  • 通讯作者:
    Elsayed Z. Soliman
ECG-AI: AN EXTERNALLY VALIDATED DEEP LEARNING MODEL TO PREDICT HEART FAILURE RISK
  • DOI:
    10.1016/s0735-1097(22)01319-5
  • 发表时间:
    2022-03-08
  • 期刊:
  • 影响因子:
  • 作者:
    Oguz Akbilgic;Liam Butler;Ibrahim Karabayir;Dalane W. Kitzman;Gari Clifford;Lin Yee Chen;Alvaro Alonso;Patricia P. Chang;Elsayed Z. Soliman
  • 通讯作者:
    Elsayed Z. Soliman

Lin Yee Chen的其他文献

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{{ truncateString('Lin Yee Chen', 18)}}的其他基金

Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related Dementias
认知障碍和痴呆、血管性脑损伤和心房肌病:对预防阿尔茨海默病相关痴呆的影响
  • 批准号:
    10814076
  • 财政年份:
    2023
  • 资助金额:
    $ 12.66万
  • 项目类别:
Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related Dementias
西班牙裔/拉丁裔的认知衰老、大脑形态和心律失常:对预防和管理阿尔茨海默病相关痴呆的影响
  • 批准号:
    10448081
  • 财政年份:
    2022
  • 资助金额:
    $ 12.66万
  • 项目类别:
Glucose patterns and cardiac arrhythmias in older adults with diabetes
老年糖尿病患者的血糖模式和心律失常
  • 批准号:
    10360749
  • 财政年份:
    2022
  • 资助金额:
    $ 12.66万
  • 项目类别:
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias
运动、睡眠和心律数字信号在阿尔茨海默病和相关痴呆症检测中的新应用
  • 批准号:
    10710169
  • 财政年份:
    2022
  • 资助金额:
    $ 12.66万
  • 项目类别:
Glucose patterns and cardiac arrhythmias in older adults with diabetes
老年糖尿病患者的血糖模式和心律失常
  • 批准号:
    10597965
  • 财政年份:
    2022
  • 资助金额:
    $ 12.66万
  • 项目类别:
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias
运动、睡眠和心律数字信号在阿尔茨海默病和相关痴呆症检测中的新应用
  • 批准号:
    10525869
  • 财政年份:
    2022
  • 资助金额:
    $ 12.66万
  • 项目类别:
Mentoring and Research to ClassifyAtrial Cardiomyopathy
心房心肌病分类的指导和研究
  • 批准号:
    10439909
  • 财政年份:
    2021
  • 资助金额:
    $ 12.66万
  • 项目类别:
Mentoring and Research to Classify Atrial Cardiomyopathy
心房心肌病分类的指导和研究
  • 批准号:
    10307378
  • 财政年份:
    2021
  • 资助金额:
    $ 12.66万
  • 项目类别:
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
左心房异常和心房颤动相关的脑梗塞和认知能力下降
  • 批准号:
    9495380
  • 财政年份:
    2018
  • 资助金额:
    $ 12.66万
  • 项目类别:
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
左心房异常和心房颤动相关的脑梗塞和认知能力下降
  • 批准号:
    9900061
  • 财政年份:
    2018
  • 资助金额:
    $ 12.66万
  • 项目类别:

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