Project 1

项目1

• 批准号: 10360625
• 负责人: DAVID D LO
• 金额: $ 38.34万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-08 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360625
• 关键词: Aerosols; Affect; Agriculture; Allergens; Asthma; Biocompatible Materials; Biological; Biological Assay; Chemicals; Chronic; Chronic Obstructive Pulmonary Disease; Clinical; Collaborations; Collection; Communication; Communities; Consultations; Data; Databases; Dust; Employment; Environmental Exposure; Environmental Health; Epidemiology; Exposure to; Family; Geography; Health; Health Disparities Research; Housing; Incidence; Inflammatory Response; Infrastructure; Latino; Lead; Lung; Maps; Modeling; Monitor; Movement; Network-based; Outcome; Particulate; Pattern; Plants; Population; Protocols documentation; Pulmonary Heart Disease; Pulmonary Inflammation; Research; Research Project Grants; Resources; Sea; Seasonal Variations; Site; Socioeconomic Status; Source; Testing; Vascular Diseases; Work; aerosolized; base; community engagement; health disparity; improved; interdisciplinary approach; lung health; marine organism; microbial; mineral dust; mouse model; particle; pollutant; pollutant transport; programs; remote sensing; soil sampling; trend; water sampling

U54 Research Project 1: Disparities in environmental exposures and health impacts Abstract The main premise of the proposed research is that health disparities in the eastern Coachella Valley (ECV), especially with regard to asthma and cardiopulmonary disease within the Latino community, are significantly affected by differential chronic environmental exposures to aerosols including biological materials (e.g., allergens and microbial components). To focus on the specific question of environmental exposures and health, we aim to develop a monitoring protocol and database that would allow us to assess correlates between aerosolized particulate components, effects on pulmonary inflammatory responses, and the epidemiology of asthma and other cardiopulmonary diseases in the Coachella Valley. We aim to accomplish this in conjunction with a community advisory board to enable continuous community engagement. The research program will include transport studies to identify patterns of particle/pollutant transport in the Coachella Valley, collection of particulate, soil and water samples in and near the Salton Sea to track the origins and movement of biological components in aerosols, and exposure of the collected material in mouse models to identify materials that may contribute to lung inflammation and asthma in the community.

U54 研究项目 1：环境暴露和健康影响的差异 抽象的 本研究的主要前提是东部地区的健康差距 科切拉山谷 (ECV)，特别是在哮喘和心肺疾病方面 拉丁裔社区受到不同的慢性环境暴露的显着影响 包括生物材料（例如过敏原和微生物成分）的气溶胶。集中注意力 关于环境暴露和健康的具体问题，我们的目标是制定一个监测 协议和数据库使我们能够评估气溶胶颗粒之间的相关性 哮喘的成分、对肺部炎症反应的影响和流行病学 以及科切拉山谷的其他心肺疾病。我们的目标是在 与社区咨询委员会合作，以实现持续的社区参与。 该研究计划将包括传输研究，以确定颗粒/污染物的模式 科切拉山谷的运输，收集及其附近的颗粒物、土壤和水样本 索尔顿海追踪气溶胶中生物成分的起源和运动，以及 将收集到的材料暴露在小鼠模型中，以确定可能有助于 社区中的肺部炎症和哮喘。