Project 1

U54研究项目1：环境暴露和健康影响的差异 摘要 拟议研究的主要前提是东部地区的健康差距 科切拉谷(ECV)，特别是关于哮喘和心肺疾病 拉丁裔社区，受到不同的慢性环境暴露的显著影响 包括生物材料(如过敏原和微生物成分)在内的气雾剂。集中精力 关于环境暴露和健康的具体问题，我们的目标是制定一项监测 协议和数据库，使我们能够评估气雾化颗粒物之间的相关性 成分、对肺部炎症反应的影响以及哮喘的流行病学 以及科切拉山谷的其他心肺疾病。我们的目标是在以下时间实现这一目标 与社区咨询委员会合作，使社区能够持续参与。 研究计划将包括运输研究，以确定颗粒物/污染物的模式 科切拉河谷的运输，收集颗粒、土壤和附近的水样 在索尔顿海追踪气溶胶中生物成分的来源和移动，以及 在小鼠模型中暴露收集的材料，以确定可能有助于 肺部炎症和哮喘在社区。

U54 Research Project 1: Disparities in environmental exposures and health impacts Abstract The main premise of the proposed research is that health disparities in the eastern Coachella Valley (ECV), especially with regard to asthma and cardiopulmonary disease within the Latino community, are significantly affected by differential chronic environmental exposures to aerosols including biological materials (e.g., allergens and microbial components). To focus on the specific question of environmental exposures and health, we aim to develop a monitoring protocol and database that would allow us to assess correlates between aerosolized particulate components, effects on pulmonary inflammatory responses, and the epidemiology of asthma and other cardiopulmonary diseases in the Coachella Valley. We aim to accomplish this in conjunction with a community advisory board to enable continuous community engagement. The research program will include transport studies to identify patterns of particle/pollutant transport in the Coachella Valley, collection of particulate, soil and water samples in and near the Salton Sea to track the origins and movement of biological components in aerosols, and exposure of the collected material in mouse models to identify materials that may contribute to lung inflammation and asthma in the community.