Project 1

U 54研究项目1：环境暴露和健康影响的差异 摘要 拟议研究的主要前提是，东部地区的健康差距 科切拉谷（ECV），特别是关于哮喘和心肺疾病， 拉丁裔社区，受到不同慢性环境暴露的严重影响 涉及包括生物材料的气溶胶（例如，过敏原和微生物成分）。专注 关于环境暴露和健康的具体问题，我们的目标是制定一项监测计划， 协议和数据库，使我们能够评估雾化颗粒之间的相关性， 成分、对肺部炎症反应的影响以及哮喘的流行病学 和其他心肺疾病的研究我们的目标是在 与社区咨询委员会合作，使社区能够持续参与。 该研究计划将包括运输研究，以确定颗粒/污染物的模式 在科切拉山谷的运输，收集颗粒，土壤和水样本和附近 索尔顿海追踪气溶胶中生物成分的起源和运动， 在小鼠模型中暴露收集的材料，以识别可能导致 肺部炎症和哮喘。

U54 Research Project 1: Disparities in environmental exposures and health impacts Abstract The main premise of the proposed research is that health disparities in the eastern Coachella Valley (ECV), especially with regard to asthma and cardiopulmonary disease within the Latino community, are significantly affected by differential chronic environmental exposures to aerosols including biological materials (e.g., allergens and microbial components). To focus on the specific question of environmental exposures and health, we aim to develop a monitoring protocol and database that would allow us to assess correlates between aerosolized particulate components, effects on pulmonary inflammatory responses, and the epidemiology of asthma and other cardiopulmonary diseases in the Coachella Valley. We aim to accomplish this in conjunction with a community advisory board to enable continuous community engagement. The research program will include transport studies to identify patterns of particle/pollutant transport in the Coachella Valley, collection of particulate, soil and water samples in and near the Salton Sea to track the origins and movement of biological components in aerosols, and exposure of the collected material in mouse models to identify materials that may contribute to lung inflammation and asthma in the community.