Mechanisms of adult forebrain neural circuit regeneration

成人前脑神经回路再生机制

基本信息

  • 批准号:
    10362563
  • 负责人:
  • 金额:
    $ 51.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-05-15 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

Project Summary: The neural circuit that regulates birdsong, a highly precise, learned sensorimotor behavior, excels for study of fundamental mechanisms of adult circuit plasticity. The song system is a unique model of naturally occurring degeneration and compensatory regeneration in a behaviorally relevant neural circuit in adult brains. This circuit shows exaggerated seasonal degeneration and reconstruction via neurogenesis, in response to changes in circulating steroid hormone levels. Our long-term goal is to understand the fundamental mechanisms by which steroid hormones and neurotrophins interact to regulate plasticity of neural circuits and behavior. On a translational level, our goal is to understand how forebrain circuits can regenerate to support performance of complex learned motor skills. The central hypothesis of the proposed aims is that seasonal changes in hormones trigger changes in anterograde and retrograde trophic signaling that lead to remodeling of the HVC-RA circuit and changes in song behavior in adult birds.The goal of this application is to identify the trophic signaling pathways (molecular and electrophysiological) that regulate the the incorporation of newborn neurons to regenerate this circuit. This research will advance the field by elucidating fundamental issues of adult circuit plasticity. This topic is of translational relevance for exploiting endogenous or exogenous stem cells for therapeutic repair of injured or dysfunctional circuits in humans. These fundamental issues include whether new neurons added to adult circuits establish functional connections with efferent nuclei and restore behavior (Aim 1), the role of activity regulated genes in mediating retrograde trophic effects of neuronal activity on presynaptic adult neurogenesis (Aim 2), the role of calcium channels in mediating the transsynaptic neurotrophic regulation of postsynaptic activity (Aim 3), and the role of pre- and/or postsynaptic neuronal activity in maintaining a regenerated adult circuit (Aim 4).
项目总结:

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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DAVID J PERKEL其他文献

DAVID J PERKEL的其他文献

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{{ truncateString('DAVID J PERKEL', 18)}}的其他基金

Neuromodulation in the auditory system
听觉系统的神经调节
  • 批准号:
    9198445
  • 财政年份:
    2014
  • 资助金额:
    $ 51.05万
  • 项目类别:
Neuromodulation in the auditory system
听觉系统的神经调节
  • 批准号:
    8791894
  • 财政年份:
    2014
  • 资助金额:
    $ 51.05万
  • 项目类别:
Neuromodulation in the auditory system
听觉系统的神经调节
  • 批准号:
    9402597
  • 财政年份:
    2014
  • 资助金额:
    $ 51.05万
  • 项目类别:
Neuromodulation in the auditory system
听觉系统的神经调节
  • 批准号:
    9086809
  • 财政年份:
    2014
  • 资助金额:
    $ 51.05万
  • 项目类别:
Neuromodulation in the auditory system
听觉系统的神经调节
  • 批准号:
    8630806
  • 财政年份:
    2014
  • 资助金额:
    $ 51.05万
  • 项目类别:
COMPUTER RESOURCES CORE
计算机资源核心
  • 批准号:
    6953878
  • 财政年份:
    2005
  • 资助金额:
    $ 51.05万
  • 项目类别:
A telencephalic pattern generator for song
歌曲的端脑模式生成器
  • 批准号:
    6873636
  • 财政年份:
    2004
  • 资助金额:
    $ 51.05万
  • 项目类别:
A telencephalic pattern generator for song
歌曲的端脑模式生成器
  • 批准号:
    6772813
  • 财政年份:
    2004
  • 资助金额:
    $ 51.05万
  • 项目类别:
Synaptic processing in the basal ganglia
基底神经节的突触处理
  • 批准号:
    6617177
  • 财政年份:
    2003
  • 资助金额:
    $ 51.05万
  • 项目类别:
Synaptic processing in the basal ganglia
基底神经节的突触处理
  • 批准号:
    8247858
  • 财政年份:
    2003
  • 资助金额:
    $ 51.05万
  • 项目类别:

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