The NIGMS Human Genetic Cell Repository

NIGMS 人类遗传细胞库

• 批准号: 10361519
• 负责人: Nahid Turan
• 金额: $ 182.55万
• 依托单位: CORIELL INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10361519
• 关键词: Advertisements; Area; Biocompatible Materials; Biomedical Research; Catalogs; Cell Line; Cells; Chromosome abnormality; Clinical; Collection; Communities; Custom; DNA; Databases; Development; Diagnosis; Disease; Educational process of instructing; Electronic Mail; Exhibits; Family; Foundations; Funding Opportunities; Genetic Diseases; Genetic Research; Genetic Services; Geography; Goals; Hereditary Disease; Human; Human Genetics; Individual; Information Distribution; Institutes; Institutional Review Boards; Interview; Journals; Life; Maintenance; Medical Research; Mission; National Institute of General Medical Sciences; Newsletter; Pamphlets; Patients; Population; Preparation; Prevention; Procedures; Process; Protocols documentation; Quality Control; RNA; Reporting; Research; Research Personnel; Research Support; Resources; Sampling; Secure; Services; Technology; Testing; Update; cell repository; computerized; disease diagnosis; established cell line; high standard; induced pluripotent stem cell; innovation; interest; meetings; permanent cell line; repository; response; social media

The NIGMS Human Genetic Cell Repository U42 Application FOA No.: RFA-GM-19-002 Project Summary/Abstract Coriell Institute for Medical Research (Coriell) proposes to maintain and expand the NIGMS Human Genetic Cell Repository (HGCR). The NIGMS HGCR, established in 1972 at Coriell by the National Institute of General Medical Sciences (NIGMS), provides a readily accessible, centralized resource for biospecimens from individuals with inherited disorders, chromosomal abnormalities, apparently healthy individuals, and individuals of diverse geographic origins for use in biomedical research. The primary goal of the NIGMS HGCR is to stimulate and facilitate biomedical research, teaching, and the diagnosis and prevention of human genetic diseases by establishing and maintaining a repository of high quality, uncontaminated, well characterized, and clinically well-documented cell lines and DNA and making these resources available to investigators throughout the U.S. and abroad. The NIGMS HGCR mission is in line with the NIGMS mission, which is “to support research that increases understanding of life processes and lays the foundation for advances in disease diagnosis, treatment and prevention”. The NIGMS HGCR’s activities, all governed by high standards of quality, will include (1) collection, establishment, characterization, maintenance, and distribution of cell lines, (2) preparation, storage and distribution of DNA from cell lines, (3) the development and offering of special genetic services and biomaterials in response to customer requests, (4) maintenance of a comprehensive database and online catalog, and (5) publicizing the NIGMS HGCR’s collections. The NIGMS HGCR will maintain, grow and distribute the current collection of approximately 11,800 unique cell lines, 6,400 DNA samples, and 54 human iPSC lines in its online catalog, as well as newly acquired resources. The NIGMS HGCR will continue to create human induced pluripotent stem cell (iPSC) lines at Coriell by reprogramming certain NIGMS HGCR cell lines. Additionally, Coriell is committed to integrating state-of-the-art technologies into its activities and will continue to offer a wide range of cutting edge services that enhance the utility of the HGCR collection to the genetic research community.

NIGMS人类遗传细胞库 U42应用 FOA编号：RFA-GM-19-002 项目总结/摘要 Coriell医学研究所（Coriell）建议维持和扩大NIGMS 人类遗传细胞库（HGCR）。NIGMS HGCR于1972年在Coriell成立， 国家普通医学科学研究所（NIGMS），提供了一个方便， 遗传性疾病个体染色体生物标本集中资源 异常，明显健康的个体，以及不同地理来源的个体， 用于生物医学研究。NIGMS HGCR的主要目标是刺激和促进 生物医学研究、教学以及人类遗传疾病的诊断和预防， 建立和维持一个高质量、未受污染、特性良好的储存库， 以及临床上有据可查的细胞系和DNA， 调查人员在美国和国外。NIGMS HGCR的使命符合 NIGMS的使命是“支持增加对生命过程的理解的研究 并为疾病诊断、治疗和预防的进步奠定基础”。的 NIGMS HGCR的活动，所有由高标准的质量，将包括（1）收集， 细胞系的建立、表征、维持和分布，（2）制备， 细胞系DNA的储存和分配，（3）特殊的 （4）根据客户要求提供遗传服务和生物材料， 全面的数据库和在线目录，以及（5）宣传NIGMS HGCR的 收藏. NIGMS HGCR将维护，发展和分发当前收集的 大约11，800个独特的细胞系，6，400个DNA样本和54个人类iPSC系， 在线目录，以及新获得的资源。NIGMS HGCR将继续创造 在Coriell通过重编程某些NIGMS的人诱导多能干细胞（iPSC）系 HGCR细胞系。此外，Coriell致力于整合最先进的技术， 并将继续提供广泛的尖端服务， HGCR收集对遗传研究界的效用。