The NIGMS Human Genetic Cell Repository Cooperative Agreement (U42) Application

NIGMS人类遗传细胞库合作协议（U42）申请

• 批准号: 9034612
• 负责人: Nahid Turan
• 金额: $ 280万
• 依托单位: CORIELL INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-15 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9034612
• 关键词: Advertisements; Area; Biocompatible Materials; Biological; Biomedical Research; Cataloging; Catalogs; Cell Culture Techniques; Cell Line; Cells; Chromosome abnormality; Collection; Communities; Custom; DNA; Databases; Development; Diagnosis; Disease; Disease model; Educational process of instructing; Electronic Mail; Exhibits; Family; Foundations; Funding Opportunities; Gene Mutation; Genetic Services; Goals; Health; Hereditary Disease; Human; Human Genetics; Inborn Genetic Diseases; Individual; Information Distribution; Inherited; Institutes; Institutional Review Boards; Journals; Life; Maintenance; Medical Research; Mission; National Institute of General Medical Sciences; Newsletter; Pamphlets; Patients; Preparation; Prevention; Procedures; Process; Protocols documentation; Quality Control; RNA; Reporting; Research Personnel; Research Support; Resources; Sampling; Secure; Services; Stem cells; Testing; U-Series Cooperative Agreements; Update; computerized; disease diagnosis; drug discovery; established cell line; high standard; induced pluripotent stem cell; interest; meetings; permanent cell line; repository; response

 DESCRIPTION (provided by applicant): Coriell Institute for Medical Research (Coriell) proposes to maintain and expand the NIGMS Human Genetic Cell Repository. The NIGMS Repository, established in 1972 at Coriell by the National Institute of General Medical Sciences (NIGMS), provides a readily accessible, centralized resource for biospecimens from individuals with inherited disorders, chromosomal abnormalities, apparently healthy individuals, and individuals of diverse geographic origins for use in biomedical research. The primary goal of the NIGMS Repository is to stimulate and facilitate biomedical research, teaching, and the diagnosis and prevention of human genetic diseases by establishing and maintaining a repository of high quality, uncontaminated, well characterized, and clinically well-documented cell lines and DNA and making these resources available to investigators throughout the U.S. and abroad. The NIGMS Repository mission is in line with the NIGMS mission, which is "to support research that increases understanding of life processes and lays the foundation for advances in disease diagnosis, treatment and prevention". The NIGMS Repository's activities, all governed by high standards of quality, will include (1) collection, establishment, characterization, maintenance, and distribution of cell lines, (2) preparation, storage and distribution of DNA from cell lines, (3) the development and offering of special services and biomaterials in response to customer requests, (4) maintenance of a comprehensive database and online catalog, and (5) publicizing the NIGMS Repository's collection. The NIGMS Repository will maintain and distribute the current collection of approximately 11,300 cell lines and 5,600 DNA samples in its online catalog, as well as newly acquired resources. The NIGMS Repository will create human induced pluripotent stem cell (iPSC) lines at Coriell by reprogramming certain NIGMS Repository cell lines and will culture, characterize and distribute both iPSC lines reprogrammed at Coriell and those submitted by external investigators.

 描述（由申请人提供）：Coriell医学研究所（Coriell）建议维护和扩展NIGMS人类遗传细胞库。国家普通医学科学研究所（NIGMS）于1972年在Coriell建立了NIGMS储存库，为遗传性疾病、染色体异常、明显健康的个体和不同地理来源的个体的生物标本提供了一个易于访问的集中资源，用于生物医学研究。NIGMS知识库的主要目标是通过建立和维护一个高质量，无污染，良好表征和临床记录良好的细胞系和DNA的知识库，并使这些资源可供美国和国外的研究人员使用，来促进生物医学研究，教学以及人类遗传疾病的诊断和预防。NIGMS知识库的使命与NIGMS的使命一致，即“支持增加对生命过程的理解并为疾病诊断、治疗和预防的进步奠定基础的研究”。NIGMS知识库的活动，所有由高标准的质量，将包括（1）收集，建立，表征，维护，和细胞系的分布，（2）制备，储存和细胞系的DNA分布，（3）开发和提供特殊服务和生物材料，以响应客户的要求，（4）维护一个全面的数据库和在线目录，（5）宣传NIGMS馆藏。NIGMS储存库将在其在线目录中维护和分发目前收集的约11，300个细胞系和5，600个DNA样本，以及新获得的资源。NIGMS Repository将通过重新编程某些NIGMS Repository细胞系来在Coriell创建人类诱导多能干细胞（iPSC）系，并将培养、表征和分发在Coriell重新编程的iPSC系以及外部研究人员提交的iPSC系。