Scientific and Administrative Management Core

NIGMS人类遗传细胞库 U42应用 FOA编号：RFA-GM-15-005 项目摘要/摘要 科里尔医学研究所(Coriell)建议维持和扩大NIGMS 人类遗传细胞库。NIGMS资料库，1972年由 国家普通医学科学研究所(NIGMS)，提供了一个易于访问、 来自遗传性疾病个体的生物样本的集中资源，染色体 异常，表面上健康的个人，以及不同地理来源的个人 用于生物医学研究。NIGMS存储库的主要目标是刺激和 促进生物医学研究、教学以及人类基因的诊断和预防 通过建立和维护一个高质量、无污染、 特征化的，临床上记录良好的细胞系和DNA，并使这些资源 可供全美和海外的调查人员使用。NIGMS存储库任务在 与NIGMS的使命一致，那就是“支持增加对生命的理解的研究” 为疾病诊断、治疗和治疗的进展奠定基础 预防“。NIGMS存储库的活动，都受到高标准的质量管理，将 包括(1)细胞收集、建立、表征、维护和分发 (2)细胞系DNA的制备、储存和分配；(3)细胞系DNA的发育和 应客户要求提供特殊服务和生物材料，(4)维护 一个全面的数据库和在线目录，以及(5)宣传NIGMS储存库的 收集。NIGMS存储库将维护和分发当前的 在其在线目录中，大约有11,300个细胞系和5,600个DNA样本，以及新的 获得的资源。NIGMS资料库将创造人类诱导的多能干细胞 (IPSC)在Coriell通过对某些NIGMS储存库细胞系和Will培养进行重新编程， 描述和分发在Coriell重新编程的IPSC生产线和由 外部调查人员。

The NIGMS Human Genetic Cell Repository U42 Application FOA No.: RFA-GM-15-005 Project Summary/Abstract Coriell Institute for Medical Research (Coriell) proposes to maintain and expand the NIGMS Human Genetic Cell Repository. The NIGMS Repository, established in 1972 at Coriell by the National Institute of General Medical Sciences (NIGMS), provides a readily accessible, centralized resource for biospecimens from individuals with inherited disorders, chromosomal abnormalities, apparently healthy individuals, and individuals of diverse geographic origins for use in biomedical research. The primary goal of the NIGMS Repository is to stimulate and facilitate biomedical research, teaching, and the diagnosis and prevention of human genetic diseases by establishing and maintaining a repository of high quality, uncontaminated, well characterized, and clinically well-documented cell lines and DNA and making these resources available to investigators throughout the U.S. and abroad. The NIGMS Repository mission is in line with the NIGMS mission, which is “to support research that increases understanding of life processes and lays the foundation for advances in disease diagnosis, treatment and prevention”. The NIGMS Repository’s activities, all governed by high standards of quality, will include (1) collection, establishment, characterization, maintenance, and distribution of cell lines, (2) preparation, storage and distribution of DNA from cell lines, (3) the development and offering of special services and biomaterials in response to customer requests, (4) maintenance of a comprehensive database and online catalog, and (5) publicizing the NIGMS Repository’s collection. The NIGMS Repository will maintain and distribute the current collection of approximately 11,300 cell lines and 5,600 DNA samples in its online catalog, as well as newly acquired resources. The NIGMS Repository will create human induced pluripotent stem cell (iPSC) lines at Coriell by reprogramming certain NIGMS Repository cell lines and will culture, characterize and distribute both iPSC lines reprogrammed at Coriell and those submitted by external investigators.