Role of SIRT6 in the pancreatic beta cell aging

SIRT6在胰腺β细胞衰老中的作用

基本信息

项目摘要

Project Summary During aging, pancreatic beta cells undergo a decline in insulin secretion capacity, and this contributes to nearly 3-fold high diabetes prevalence in people aged over 65 years compared to the general population. Sirtuin 6 (SIRT6), a histone deacetylase, has been suggested to be a longevity factor. In the preliminary study, we have demonstrated that SIRT6 is required to maintain normal beta cell function and SIRT6 is downregulated in the beta cells during aging. Therefore, we hypothesize that SIRT6 plays an important role in the protection of pancreatic beta cells against aging-associated cellular damage. In this application, we will investigate the SIRT6 function and mechanism in the regulation of pancreatic beta cell aging. It is our expectation that the findings from this project will advance our understanding of the fundamental process of the aging of pancreatic beta cells and provide potential novel targets for the development of prevention and treatment of the age-related diabetes.
项目总结

项目成果

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X Charlie Dong其他文献

X Charlie Dong的其他文献

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{{ truncateString('X Charlie Dong', 18)}}的其他基金

The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
PNPLA3-148M变异在酒精性肝损伤中的病理生理作用
  • 批准号:
    10366395
  • 财政年份:
    2022
  • 资助金额:
    $ 23.78万
  • 项目类别:
Role of SIRT6 in the pancreatic beta cell aging
SIRT6在胰腺β细胞衰老中的作用
  • 批准号:
    10641670
  • 财政年份:
    2022
  • 资助金额:
    $ 23.78万
  • 项目类别:
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
PNPLA3-148M变异在酒精性肝损伤中的病理生理作用
  • 批准号:
    10613405
  • 财政年份:
    2022
  • 资助金额:
    $ 23.78万
  • 项目类别:
Role of ATG14 in the regulation of hepatic function
ATG14在肝功能调节中的作用
  • 批准号:
    10596539
  • 财政年份:
    2020
  • 资助金额:
    $ 23.78万
  • 项目类别:
Role of ATG14 in the regulation of hepatic function
ATG14在肝功能调节中的作用
  • 批准号:
    10371047
  • 财政年份:
    2020
  • 资助金额:
    $ 23.78万
  • 项目类别:
Epigenetic regulation in liver fibrosis
肝纤维化的表观遗传调控
  • 批准号:
    10640141
  • 财政年份:
    2020
  • 资助金额:
    $ 23.78万
  • 项目类别:
Epigenetic regulation in liver fibrosis
肝纤维化的表观遗传调控
  • 批准号:
    10172893
  • 财政年份:
    2020
  • 资助金额:
    $ 23.78万
  • 项目类别:
Epigenetic regulation in liver fibrosis
肝纤维化的表观遗传调控
  • 批准号:
    10428589
  • 财政年份:
    2020
  • 资助金额:
    $ 23.78万
  • 项目类别:
Role of sirtuin 6 in the protection of liver from the alcohol-induced injury
Sirtuin 6在保护肝脏免受酒精损伤中的作用
  • 批准号:
    9244917
  • 财政年份:
    2017
  • 资助金额:
    $ 23.78万
  • 项目类别:
Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver disease
Sestrin3 在酒精性和非酒精性脂肪肝发病机制中的作用
  • 批准号:
    9303199
  • 财政年份:
    2016
  • 资助金额:
    $ 23.78万
  • 项目类别:

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    9976990
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