SIRT6在胰腺β细胞衰老中的作用-猫眼课题宝

SIRT6在胰腺β细胞衰老中的作用

批准号：

10371337

负责人：

X Charlie Dong

金额：

$23.78万

依托单位：

INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS

依托单位国家：

美国

项目类别：

财政年份：

2022

资助国家：

美国

项目状态：

已结题

起止时间：

2022-06-15 至 2024-02-29

来源：

https://reporter.nih.gov/project-details/10371337

关键词：

Age Age-Years Aging B Cell Proliferation B-Cell Development Beta Cell Biological Process Calcium Signaling Cell Aging Cell Death Cell membrane Cell physiology DNA Damage Data Deacetylase Defect Development Diabetes Mellitus Diet Disease Epigenetic Process Female Gene Expression Gene Expression Regulation General Population Genes Glucose Glucose Intolerance Guanosine Triphosphate Phosphohydrolases HDAC4 gene Histologic Homeostasis Human Impairment Insulin Intervention Islets of Langerhans Knock-out Knockout Mice Knowledge Life Literature Longevity Metabolic Metabolism Mission Mitochondria Modeling Molecular and Cellular Biology Monitor Monomeric GTP-Binding Proteins Mus Non-Insulin-Dependent Diabetes Mellitus Oxidative Stress Persons Phenotype Physiological Physiology Play Population Premature Mortality Prevalence Prevention Process Proteins Public Health Regulation Research Risk Factors Role Sirtuins Structure of beta Cell of islet Testing Transgenes Transgenic Mice United States National Institutes of Health age related anti aging base blood glucose regulation burden of illness cell age cell injury diabetes pathogenesis epigenetic regulation expectation gene function glucose metabolism high risk human old age (65+)improved innovation insight insulin secretion male middle age molecular phenotype mouse model new therapeutic target novel overexpression therapeutic development transgene expression voltage

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Project Summary During aging, pancreatic beta cells undergo a decline in insulin secretion capacity, and this contributes to nearly 3-fold high diabetes prevalence in people aged over 65 years compared to the general population. Sirtuin 6 (SIRT6), a histone deacetylase, has been suggested to be a longevity factor. In the preliminary study, we have demonstrated that SIRT6 is required to maintain normal beta cell function and SIRT6 is downregulated in the beta cells during aging. Therefore, we hypothesize that SIRT6 plays an important role in the protection of pancreatic beta cells against aging-associated cellular damage. In this application, we will investigate the SIRT6 function and mechanism in the regulation of pancreatic beta cell aging. It is our expectation that the findings from this project will advance our understanding of the fundamental process of the aging of pancreatic beta cells and provide potential novel targets for the development of prevention and treatment of the age-related diabetes.

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