Role of SIRT6 in the pancreatic beta cell aging
SIRT6在胰腺β细胞衰老中的作用
基本信息
- 批准号:10371337
- 负责人:
- 金额:$ 23.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-15 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:AgeAge-YearsAgingB Cell ProliferationB-Cell DevelopmentBeta CellBiological ProcessCalcium SignalingCell AgingCell DeathCell membraneCell physiologyDNA DamageDataDeacetylaseDefectDevelopmentDiabetes MellitusDietDiseaseEpigenetic ProcessFemaleGene ExpressionGene Expression RegulationGeneral PopulationGenesGlucoseGlucose IntoleranceGuanosine Triphosphate PhosphohydrolasesHDAC4 geneHistologicHomeostasisHumanImpairmentInsulinInterventionIslets of LangerhansKnock-outKnockout MiceKnowledgeLifeLiteratureLongevityMetabolicMetabolismMissionMitochondriaModelingMolecular and Cellular BiologyMonitorMonomeric GTP-Binding ProteinsMusNon-Insulin-Dependent Diabetes MellitusOxidative StressPersonsPhenotypePhysiologicalPhysiologyPlayPopulationPremature MortalityPrevalencePreventionProcessProteinsPublic HealthRegulationResearchRisk FactorsRoleSirtuinsStructure of beta Cell of isletTestingTransgenesTransgenic MiceUnited States National Institutes of Healthage relatedanti agingbaseblood glucose regulationburden of illnesscell agecell injurydiabetes pathogenesisepigenetic regulationexpectationgene functionglucose metabolismhigh riskhuman old age (65+)improvedinnovationinsightinsulin secretionmalemiddle agemolecular phenotypemouse modelnew therapeutic targetnoveloverexpressiontherapeutic developmenttransgene expressionvoltage
项目摘要
Project Summary
During aging, pancreatic beta cells undergo a decline in insulin secretion capacity, and this
contributes to nearly 3-fold high diabetes prevalence in people aged over 65 years compared to the
general population. Sirtuin 6 (SIRT6), a histone deacetylase, has been suggested to be a longevity factor.
In the preliminary study, we have demonstrated that SIRT6 is required to maintain normal beta cell
function and SIRT6 is downregulated in the beta cells during aging. Therefore, we hypothesize that SIRT6
plays an important role in the protection of pancreatic beta cells against aging-associated cellular
damage. In this application, we will investigate the SIRT6 function and mechanism in the regulation of
pancreatic beta cell aging. It is our expectation that the findings from this project will advance our
understanding of the fundamental process of the aging of pancreatic beta cells and provide potential
novel targets for the development of prevention and treatment of the age-related diabetes.
项目摘要
在衰老过程中,胰腺β细胞的胰岛素分泌能力下降,
导致65岁以上人群的糖尿病患病率是
一般人口。Sirtuin 6(SIRT6)是一种组蛋白脱乙酰酶,被认为是一种长寿因子。
在初步研究中,我们已经证明SIRT6是维持正常β细胞所必需的。
在衰老过程中,β细胞中的SIRT6功能下调。因此,我们假设SIRT6
在保护胰腺β细胞对抗衰老相关的细胞凋亡中起重要作用。
损害在本申请中,我们将研究SIRT6在调节细胞凋亡中的功能和机制。
胰腺β细胞老化我们期望,该项目的发现将推动我们的
了解胰腺β细胞老化的基本过程,并提供潜在的
开发预防和治疗年龄相关糖尿病的新靶点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('X Charlie Dong', 18)}}的其他基金
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
PNPLA3-148M变异在酒精性肝损伤中的病理生理作用
- 批准号:
10366395 - 财政年份:2022
- 资助金额:
$ 23.78万 - 项目类别:
Role of SIRT6 in the pancreatic beta cell aging
SIRT6在胰腺β细胞衰老中的作用
- 批准号:
10641670 - 财政年份:2022
- 资助金额:
$ 23.78万 - 项目类别:
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
PNPLA3-148M变异在酒精性肝损伤中的病理生理作用
- 批准号:
10613405 - 财政年份:2022
- 资助金额:
$ 23.78万 - 项目类别:
Role of ATG14 in the regulation of hepatic function
ATG14在肝功能调节中的作用
- 批准号:
10596539 - 财政年份:2020
- 资助金额:
$ 23.78万 - 项目类别:
Role of ATG14 in the regulation of hepatic function
ATG14在肝功能调节中的作用
- 批准号:
10371047 - 财政年份:2020
- 资助金额:
$ 23.78万 - 项目类别:
Role of sirtuin 6 in the protection of liver from the alcohol-induced injury
Sirtuin 6在保护肝脏免受酒精损伤中的作用
- 批准号:
9244917 - 财政年份:2017
- 资助金额:
$ 23.78万 - 项目类别:
Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver disease
Sestrin3 在酒精性和非酒精性脂肪肝发病机制中的作用
- 批准号:
9303199 - 财政年份:2016
- 资助金额:
$ 23.78万 - 项目类别:
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