Epigenetic regulation in liver fibrosis
肝纤维化的表观遗传调控
基本信息
- 批准号:10428589
- 负责人:
- 金额:$ 45.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAffectAlcoholsAnimal ModelCCAAT-Enhancer-Binding ProteinsCaloriesCell DeathCell LineCell modelChromatinCirrhosisComplexCuesDataDeacetylaseDevelopmentDietDiseaseDisease ProgressionDrug toxicityEnvironmental Risk FactorEpigenetic ProcessExtracellular MatrixFamily memberFatty LiverFibrosisFoundationsFunctional disorderFutureGeneral PopulationGenesGeneticHepaticHepatic FibrogenesisHepatic Stellate CellHepatocyteHistone DeacetylaseHomologous ProteinHumanIn VitroInflammationInvestigationKnockout MiceKnowledgeLifeLinkLiverLiver FibrosisLiver diseasesLong-Term EffectsMissionMolecularMolecular ProfilingMusObesityPathogenesisPathway interactionsPatientsPhysiologicalPlayPrevalencePreventionPrimary carcinoma of the liver cellsProcessProductionProteinsPublic HealthRegulationResearchRoleSeveritiesSignal TransductionSirtuinsTestingTherapeutic InterventionTissuesTransgenic MiceUnited States National Institutes of HealthVirulence FactorsVirus Diseasesburden of illnesscell typechronic liver diseasechronic liver injurycommon treatmenteffective therapyendoplasmic reticulum stressepigenetic regulationepigenomicsexperimental studygenetic makeupglucose metabolismin vivolipid metabolismliver developmentliver injurymigrationmouse modelnew therapeutic targetnon-alcoholic fatty liver diseasenonalcoholic steatohepatitisnovelsedentary lifestyletherapeutic developmenttherapeutically effectivetranscription factortranscriptomics
项目摘要
Project Summary
Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% adults in the US. NAFLD initially
manifests hepatic steatosis and progresses to nonalcoholic steatohepatitis (NASH), fibrosis, and even cirrhosis
or hepatocellular carcinoma. Liver fibrosis, a condition of elevated accumulation of extracellular matrix in the
liver, is a strong indicator of NASH severity. In most NASH patients, environmental factors such as high-calorie
diets and sedentary lifestyle are primary contributors to the disease development. Those environmental cues
often modulate epigenetic and transcription factors to acquire long-term effects. In our preliminary study, we
have identified Sirtuin 6 (Sirt6) as a key suppressor of liver fibrosis. To further investigate the role of Sirt6 in the
pathogenesis of liver fibrosis, we plan to carry out both in vitro and in vivo experiments using cell and animal
models. Hepatic stellate cells are generally considered as a major contributor to the production of extracellular
matrix in the liver after chronic liver injury. Therefore, we will focus on the regulation of hepatic stellate cells by
Sirt6 at molecular, cellular, and tissue levels. It is expected that the proposed pathophysiological and
mechanistic investigation of liver fibrosis in this application will uncover key pathways or network that is
controlled by Sirt6. Moreover, the knowledge gained from this project can help develop therapeutic
interventions for hepatic fibrosis.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('X Charlie Dong', 18)}}的其他基金
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
PNPLA3-148M变异在酒精性肝损伤中的病理生理作用
- 批准号:
10366395 - 财政年份:2022
- 资助金额:
$ 45.71万 - 项目类别:
Role of SIRT6 in the pancreatic beta cell aging
SIRT6在胰腺β细胞衰老中的作用
- 批准号:
10371337 - 财政年份:2022
- 资助金额:
$ 45.71万 - 项目类别:
Role of SIRT6 in the pancreatic beta cell aging
SIRT6在胰腺β细胞衰老中的作用
- 批准号:
10641670 - 财政年份:2022
- 资助金额:
$ 45.71万 - 项目类别:
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
PNPLA3-148M变异在酒精性肝损伤中的病理生理作用
- 批准号:
10613405 - 财政年份:2022
- 资助金额:
$ 45.71万 - 项目类别:
Role of ATG14 in the regulation of hepatic function
ATG14在肝功能调节中的作用
- 批准号:
10596539 - 财政年份:2020
- 资助金额:
$ 45.71万 - 项目类别:
Role of ATG14 in the regulation of hepatic function
ATG14在肝功能调节中的作用
- 批准号:
10371047 - 财政年份:2020
- 资助金额:
$ 45.71万 - 项目类别:
Role of sirtuin 6 in the protection of liver from the alcohol-induced injury
Sirtuin 6在保护肝脏免受酒精损伤中的作用
- 批准号:
9244917 - 财政年份:2017
- 资助金额:
$ 45.71万 - 项目类别:
Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver disease
Sestrin3 在酒精性和非酒精性脂肪肝发病机制中的作用
- 批准号:
9303199 - 财政年份:2016
- 资助金额:
$ 45.71万 - 项目类别:
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