Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver disease

项目总结 酒精性和非酒精性脂肪性肝病(分别为AFLD和NAFLD)都会导致 美国出现了严重的健康问题。几乎所有过量饮酒者和NAFLD都会发生AFLD 大约三分之一的成年人口受到这种疾病的困扰。更糟糕的是，这两种疾病都没有有效的治疗方法 目前是AFLD还是NAFLD。在这项拟议的研究中，我们计划研究分子机制。 Sestrin3(SESN3)在调节肝脂代谢中的作用。这其中有两个具体目标 项目。目的1确定SESN3对AFLD和NAFLD的保护机制 ATG14调控的自噬途径。目的2是研究SESN3-mTORC2信号转导通路在脑内的作用。 AFLD和NAFLD的发病机制。预计这项拟议研究的结果 为AFLD和NAFLD的治疗发展提供有价值的信息。

PROJECT SUMMARY Both alcoholic and non-alcoholic fatty liver diseases (AFLD and NAFLD, respectively) cause serious health problems in the US. AFLD occurs in nearly all excessive alcohol drinkers and NAFLD afflicts approximately one-third of adult population. Worse yet, there is no effective treatment for either AFLD or NAFLD at this time. In this proposed research, we plan to investigate molecular mechanisms of Sestrin3 (Sesn3) in the regulation of hepatic lipid metabolism. There are two specific aims in this project. Aim# 1 is to determine the protective mechanism of Sesn3 against AFLD and NAFLD through the Atg14-regulated autophagy pathway. Aim #2 is to examine the role of Sesn3-mTORC2 pathway in the pathogenesis of AFLD and NAFLD. It is anticipated that the findings from this proposed research should provide valuable information for therapeutic development to treat AFLD and NAFLD.