Role of ATG14 in the regulation of hepatic function
ATG14在肝功能调节中的作用
基本信息
- 批准号:10371047
- 负责人:
- 金额:$ 44.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdipose tissueAdultAffectAnabolismAnimal ModelAutophagocytosisAutophagosomeBindingBiogenesisBiological ProcessCell modelCirrhosisDataDevelopmentDietDiseaseEventFatty LiverFibrosisFunctional disorderGenesGeneticGoalsHealthHepaticHepatomegalyHomeostasisInflammationInvestigationKnockout MiceKnowledgeLifeLightLipaseLipidsLiteratureLiverMammalsMetabolismMissionMolecularMusNatureNutrientOrganellesPF4 GenePathogenesisPathogenicityPathologicPathway interactionsPhospholipidsPhysiologicalPhysiologyPlayPreventionPrimary carcinoma of the liver cellsProcessProteinsPublic HealthRegulationReportingResearchRoleTestingTherapeutic InterventionTimeTriglyceridesUnited States National Institutes of HealthYeastsbaseburden of illnesschronic liver diseasecomparativeconditional knockouteffective therapyfatty liver diseasegain of functionimprovedinsightknock-downlipid metabolismloss of functionmonolayermouse modelnew therapeutic targetnon-alcoholic fatty liver diseasenonalcoholic steatohepatitisnoveloverexpressionperilipintherapeutic development
项目摘要
Project Summary
Nonalcoholic fatty liver disease (NAFLD) affects over 30% adults in the US. The NAFLD initially manifests
as hepatic steatosis and progresses to nonalcoholic steatohepatitis (NASH), fibrosis, and even cirrhosis or
hepatocellular carcinoma. Due to the progressive nature of the disease, it is crucial to understand the early
pathogenic events of the NAFLD development. Among those early events, abnormal lipid metabolism is largely
responsible for the hepatic steatosis that is manifested as extra triglyceride accumulation in the liver in the form
of lipid droplets. Triglyceride homeostasis is a very dynamic process as it involves both biosynthesis and
breakdown. The lipid droplet mobilization remains poorly understood. In this application, the research team will
investigate the regulatory mechanisms of lipid droplet breakdown in cellular and animal models with a focus on
a key autophagy regulator – autophagy related 14. It is expected that the proposed research will provide key
mechanistic insights into the strategy for therapeutic intervention and treatment of NAFLD.
项目摘要
在美国,超过30%的成年人患有非酒精性脂肪性肝病(NAFLD)。NAFLD最初表现为
随着肝脏脂肪变性并进展为非酒精性脂肪性肝炎(NASH)、纤维化,甚至是肝硬变或
肝细胞癌。由于疾病的进行性,了解早期的
非酒精性脂肪肝发生的致病事件。在这些早期事件中,脂代谢异常在很大程度上
导致肝脏脂肪变性,表现为甘油三酯在肝脏中额外堆积
脂滴的数量。甘油三酯的动态平衡是一个非常动态的过程,因为它涉及生物合成和
崩溃了。脂滴的动员仍然知之甚少。在此应用程序中,研究团队将
在细胞和动物模型中研究脂滴破裂的调节机制,重点是
一个关键的自噬调节因子--与自噬相关的14.预计拟议的研究将提供关键
对NAFLD治疗干预和治疗策略的机械论见解。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('X Charlie Dong', 18)}}的其他基金
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
PNPLA3-148M变异在酒精性肝损伤中的病理生理作用
- 批准号:
10366395 - 财政年份:2022
- 资助金额:
$ 44.13万 - 项目类别:
Role of SIRT6 in the pancreatic beta cell aging
SIRT6在胰腺β细胞衰老中的作用
- 批准号:
10371337 - 财政年份:2022
- 资助金额:
$ 44.13万 - 项目类别:
Role of SIRT6 in the pancreatic beta cell aging
SIRT6在胰腺β细胞衰老中的作用
- 批准号:
10641670 - 财政年份:2022
- 资助金额:
$ 44.13万 - 项目类别:
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
PNPLA3-148M变异在酒精性肝损伤中的病理生理作用
- 批准号:
10613405 - 财政年份:2022
- 资助金额:
$ 44.13万 - 项目类别:
Role of ATG14 in the regulation of hepatic function
ATG14在肝功能调节中的作用
- 批准号:
10596539 - 财政年份:2020
- 资助金额:
$ 44.13万 - 项目类别:
Role of sirtuin 6 in the protection of liver from the alcohol-induced injury
Sirtuin 6在保护肝脏免受酒精损伤中的作用
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9244917 - 财政年份:2017
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$ 44.13万 - 项目类别:
Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver disease
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- 批准号:
9303199 - 财政年份:2016
- 资助金额:
$ 44.13万 - 项目类别:
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