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Role of SIRT6 in the pancreatic beta cell aging

SIRT6在胰腺β细胞衰老中的作用

基本信息

批准号：
10641670
负责人：
X Charlie Dong
金额：
$ 19.81万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10641670
关键词：
Acceleration Age Age Years Aging Beta Cell Biological Process Calcium Signaling Cell Aging Cell Death Cell Proliferation Cell membrane Cell physiology DNA Damage Data Deacetylase Defect Development Diabetes Mellitus Diet Disease Epigenetic Process Female Gene Expression Gene Expression Regulation General Population Genes Glucose Glucose Intolerance Guanosine Triphosphate Phosphohydrolases HDAC4 gene Histologic Homeostasis Human Impairment Insulin Intervention Islets of Langerhans Knock-out Knockout Mice Knowledge Life Literature Longevity Metabolic Metabolism Mission Mitochondria Modeling Molecular and Cellular Biology Monitor Monomeric GTP-Binding Proteins Mus Non-Insulin-Dependent Diabetes Mellitus Oxidative Stress Persons Phenotype Physiological Physiology Play Population Premature Mortality Prevalence Prevention Process Proteins Public Health Regulation Research Risk Factors Role Sirtuins Structure of beta Cell of islet Testing Transgenes Transgenic Mice United States National Institutes of Health age related anti aging blood glucose regulation burden of illness cell age cell injury diabetes pathogenesis endocrine pancreas development epigenetic regulation expectation gene function glucose metabolism high risk human old age (65+)improved innovation insight insulin secretion male middle age molecular phenotype mouse model new therapeutic target novel overexpression therapeutic development transgene expression voltage

项目摘要

Project Summary During aging, pancreatic beta cells undergo a decline in insulin secretion capacity, and this contributes to nearly 3-fold high diabetes prevalence in people aged over 65 years compared to the general population. Sirtuin 6 (SIRT6), a histone deacetylase, has been suggested to be a longevity factor. In the preliminary study, we have demonstrated that SIRT6 is required to maintain normal beta cell function and SIRT6 is downregulated in the beta cells during aging. Therefore, we hypothesize that SIRT6 plays an important role in the protection of pancreatic beta cells against aging-associated cellular damage. In this application, we will investigate the SIRT6 function and mechanism in the regulation of pancreatic beta cell aging. It is our expectation that the findings from this project will advance our understanding of the fundamental process of the aging of pancreatic beta cells and provide potential novel targets for the development of prevention and treatment of the age-related diabetes.

项目概要在衰老过程中，胰腺β细胞的胰岛素分泌能力会下降，这与 65 岁以上人群相比，糖尿病患病率高出近 3 倍一般人群。 Sirtuin 6 (SIRT6) 是一种组蛋白脱乙酰酶，已被认为是一种长寿因子。在初步研究中，我们已经证明SIRT6是维持正常β细胞所必需的衰老过程中，β 细胞中的 SIRT6 功能下调。因此，我们假设 SIRT6 在保护胰腺β细胞免受衰老相关细胞的影响中发挥重要作用损害。在本申请中，我们将研究 SIRT6 在调节中的功能和机制。胰腺β细胞老化。我们期望该项目的研究结果将推动我们了解胰腺β细胞衰老的基本过程并提供潜力开发预防和治疗年龄相关糖尿病的新目标。