Interdisciplinary Training in Nanotechnology for Cardiovascular and Lung Diseases in North Texas

北德克萨斯州心血管和肺部疾病纳米技术跨学科培训

• 批准号: 10206233
• 负责人: Kytai Truong Nguyen
• 金额: $ 24.85万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10206233
• 关键词: Cardiovascular Diseases; Lung diseases; Nanotechnology; Texas; Training

Although nanotechnology can be used to detect disease and improve the outcomes of cardiovascular and pulmonary healthcare, there are relatively few doctoral graduates that are trained to apply new advances in nanotechnology with a strong basic, health and translational science background. To bridge this gap, our long-term objective is to develop and operate a bioengineering doctoral training program in nanomaterials, nanoengineering and nanomedicine (DT-NEN) for cardiovascular and lung diseases. To reach this goal, we designed an integrative and interdisciplinary research training program for DT-NEN trainees by grouping participating mentors who have extensive training track records into four focused areas: (i) basic and translational sciences related to cardiovascular and lung diseases, (ii) nanoengineering strategies to facilitate vascular and lung tissue regeneration, (iii) nanomedicine for cardiovascular and lung diseases, and (iv) nanomaterials and imaging applications in detection of cardiovascular and lung disorders. Our DT-NEN program is novel as it will train doctoral students in various NEN applications for cardiovascular and lung diseases, including the use of NEN to study mechanisms involved with disease development and to facilitate tissue repair/regeneration and the traditional applications that are associated with the detection and treatment of these diseases. In addition to a new NEN curriculum, our DT-NEN trainees will also participate in several innovative training activities such as “I Engage Mentoring,” “Emerging Nanomedicine Landscape,” “Nanotechnology Risk and Toxicology Management” and “NEN Perception and Acceptance” to broaden their NEN experience. The program will also increase student involvement from underrepresented groups, especially the large Hispanic undergraduate population in Texas, via extensive recruitment activities, including “The Maverick Bridge Program,” “MavGrad Engineers” and “Students Recruiting Students.” The program will provide financial support to three pre-doctoral students in their second through third years, and the mentors and co-mentors will pay these trainees from their research grants thereafter. After completing the program, our trainees will be able to bridge the gap between theories and experiments, basic biology research and translational sciences as well as experimental and clinical applications associated with NEN for cardiovascular and lung diseases to bring these multidisciplinary fields together to facilitate improvements in the diagnosis and treatment of these diseases. Another outcome is that our DT-NEN program will provide outstanding training and research experiences to equip the next generation of investigators familiar with NEN advances in order to improve the detection and treatment efficiencies, thereby leading to better quality of life for many patients and lower associated healthcare costs. We also anticipate that the DT-NEN program will provide highly trained bioengineers, who will serve as the major workforce in various settings, including government agencies, hospitals, industrial and start-up companies as well as medical centers and universities.

虽然纳米技术可用于检测疾病和改善心血管疾病的结果， 肺保健，有相对较少的博士毕业生是受过训练，以应用新的进展， 纳米技术与强大的基础，健康和转化科学背景。为了弥补这一差距，我们 长期目标是开发和运行纳米材料生物工程博士培训计划， 纳米工程和纳米医学（DT-NEN）用于心血管和肺部疾病。为了实现这一目标，我们 设计了一个综合性和跨学科的研究培训计划，为DT-NEN学员分组 参与的导师在四个重点领域有广泛的培训记录：㈠基本和 与心血管和肺部疾病有关的转化科学，（ii）促进 血管和肺组织再生，（iii）用于心血管和肺疾病的纳米医学，和（iv） 纳米材料和成像应用在检测心血管和肺部疾病。我们的DT-NEN 该计划是新颖的，因为它将培养博士生在各种NEN应用心血管和肺 疾病，包括使用NEN研究与疾病发展有关的机制， 组织修复/再生以及与检测和治疗相关的传统应用 这些疾病。除了新的NEN课程，我们的DT-NEN学员还将参加几个 创新的培训活动，如“我从事指导”，“新兴纳米医学景观”， “纳米技术风险和毒理学管理”和“NEN的认知和接受”，以扩大其 NEN经验。该计划还将增加代表性不足的群体的学生参与， 特别是德克萨斯州大量的西班牙裔本科生，通过广泛的招聘活动，包括 “特立独行的桥梁计划”，“MavGrad工程师”和“学生招募学生”。该计划将 为三名博士预科学生提供第二年至第三年的经济支持，导师 其后，共同导师会从他们的研究赠款中支付给这些学员。完成课程后，我们 学员将能够弥合理论与实验，基础生物学研究和 转化科学以及与NEN相关的心血管实验和临床应用 和肺部疾病，将这些多学科领域结合在一起，以促进诊断和 这些疾病的治疗。另一个结果是，我们的DT-NEN计划将提供出色的培训 和研究经验，使下一代研究人员熟悉NEN的进展， 提高检测和治疗效率，从而提高许多患者的生活质量， 降低相关的医疗费用。我们还预计，DT-NEN计划将提供训练有素的 生物工程师，谁将作为主要劳动力在各种设置，包括政府机构， 医院、工业和初创公司以及医疗中心和大学。

项目成果

Investigating the Transient Regenerative Potential of Cardiac Muscle Using a Neonatal Pig Partial Apical Resection Model.

• DOI: 10.3390/bioengineering9080401
• 发表时间: 2022-08-18
• 期刊: Bioengineering (Basel, Switzerland)

IR-783 Labeling of a Peptide Receptor for 'Turn-On' Fluorescence Based Sensing.

• DOI: 10.3390/chemosensors6040047
• 发表时间: 2018-10
• 期刊: Chemosensors
• 影响因子: 4.2
• 作者: Eun-A Kwak;LeNaiya A. Kydd;Butaek Lim;J. Jaworski

Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation.

• DOI: 10.1039/c8tb01582a
• 发表时间: 2018-11
• 期刊: Journal of materials chemistry. B
• 作者: Cancan Xu;A. Kuriakose;Danh Truong;Primana Punnakitikashem;K. Nguyen;Yi Hong

BetaBuddy: An end-to-end computer vision pipeline for the automated analysis of insulin secreting β-cells.

BetaBuddy：用于自动分析胰岛素分泌β细胞的端到端计算机视觉管道。

• DOI: 10.1101/2023.04.06.535890
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Alsup,AnneM;Fowlds,Kelli;Cho,Michael;Luber,JacobM
• 通讯作者: Luber,JacobM

Luminescent Probe Based Techniques for Hypoxia Imaging.

• DOI: 10.15406/jnmr.2017.06.00160
• 发表时间: 2017-11
• 期刊: Journal of nanomedicine research
• 作者: S. Sandhu;LeNaiya A. Kydd;J. Jaworski