Core 3: Population & Data Modeling

项目摘要：人口数据和建模核心(PDMC) 目前，过量死亡降低了美国人的预期寿命，我们每年花费超过5000亿美元 关于治疗药物使用障碍及其医学后果。考虑到广谱的 物质使用的临床和经济后果，美国面临着物质使用障碍的“综合征”， 艾滋病毒、丙型肝炎病毒和细菌感染。作为回应，我们建议将以前的丙型肝炎病毒和艾滋病毒核心 人口数据和建模核心(PDMC)，具有更广泛的使命，使用辅助数据和建模来 解决这一共同点的人口结果。衡量经济价值的一种有效方法是使用 “大数据”来自真实世界。来自电子健康的链接管理记录和数据存储库 记录是对传统前瞻性研究设计的补充，是卫生经济学的基本工具 研究。当与模拟模型相结合时，管理和临床记录仍然更强大。 模拟模型可以整合关于流行性感冒流行病学和自然病史的最新知识。 物质使用障碍、治疗结果和资源利用，以提供与政策相关的见解 治疗和护理。CREILE(健康经济学治疗干预中心)的总体目标 物质使用障碍、丙型肝炎病毒和艾滋病毒)是开发和传播经济证据，告知 物质使用障碍政策和对吸毒者的丙型肝炎病毒和艾滋病病毒的护理。在此续约期内，我们 将把我们的重点扩展到在个人、系统和 社区层面有以下具体目标：1)促进使用来自Linked的人口数据 进行社区一级治疗和护理经济评估的行政和临床记录 对于物质使用障碍，以及使用物质的人中的丙型肝炎病毒和艾滋病毒，以及2)促进 模拟建模方法在农村经济和人口产出评价中的应用 物质使用障碍、丙型肝炎病毒和艾滋病毒的治疗。我们还将利用我们的 使用跨多个州机构的链接州级管理数据的独特专业知识 帮助建立在其他州建立和使用类似数据库的最佳做法。我们会 与同事合作，创建并维持一个研究人员网络，这些研究人员使用模拟模型来 告知应对阿片类药物危机的情况。我们将主办工作组年度会议，发布 确定模拟物质使用障碍和丙型肝炎病毒传播的最佳做法的手稿 在注射吸毒者中感染艾滋病毒，并与传播和政策核心密切合作，制定最佳方案 将模拟模型结果转化为可操作的政策信息的实践。

PROJECT SUMMARY: Population Data & Modeling Core (PDMC) At this time, overdose deaths reduce US life expectancy and we are spending more than $500 billion per year on treating substance use disorders and their medical consequences. Considering the wide spectrum of clinical and economic consequences of substance use, the U. faces a “syndemic” of substance use disorder, HIV, HCV, and bacterial infections. In response, we propose to replace the former HCV & HIV Core with a Population Data & Modeling Core (PDMC) that has a broader mission to use secondary data and modeling to address population outcomes of this syndemic. One powerful approach to measuring economic value is using “big data” from the real world. Linked administrative records and data repositories from electronic health records compliment traditional prospective study designs and are an essential tool for health economics research. Administrative and clinical records are still more powerful when coupled to simulation models. Simulation models can integrate the most up-to-date knowledge about the epidemiology and natural history of substance use disorders, treatment outcomes, and resource utilization to make policy-relevant insights about treatment and care. The overall aim of CHERISH (Center for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIV) is to develop and disseminate economic evidence that informs substance use disorder policy and HCV and HIV care of people who use substances. In this renewal period we will expand our focus to outcome and implementation research that is conducted at the individual, system, and community levels with the following specific aims: 1) to promote the use of population data from linked administrative and clinical records in conducting community-level economic evaluations of treatment and care for substance use disorder, and HCV and HIV among people who use substances, and 2) to advance the application of simulation modeling methods to evaluations of the economic and population outcomes of substance use disorder, HCV, and HIV treatment for people who use substances. We will also leverage our unique expertise working with linked state-level administrative data across multiple state agencies in Massachusetts to help establish best practices for building and using similar databases in other states. We will collaborate with colleagues to create and sustain a network of researchers who employ simulation models to inform the response to the opioid crisis. We will sponsor an annual working group meeting, publish manuscripts identifying best practices for simulating substance use disorder and the transmission of HCV and HIV among people who inject drugs, and work closely with the Dissemination & Policy Core to develop best practices for translating simulation model outcomes into actionable policy messages.