Core 3: Population & Data Modeling

人口数据和建模核心（PDMC） 目前，过量死亡降低了美国人的预期寿命，我们每年花费超过5000亿美元 治疗药物使用障碍及其医疗后果。考虑到广泛的 临床和经济后果的物质使用，美国。面临着物质使用障碍的“综合症”， HIV、HCV和细菌感染。有见及此，我们建议以 人口数据和建模核心（PDMC），具有更广泛的使命，使用二级数据和建模， 解决这一流行病的人口后果。衡量经济价值的一种有效方法是使用 来自真实的世界的“大数据”。来自电子健康的链接管理记录和数据存储库 记录补充了传统的前瞻性研究设计，是卫生经济学的重要工具 research.行政和临床记录在与模拟模型相结合时仍然更加强大。 模拟模型可以整合有关流行病学和自然历史的最新知识， 物质使用障碍，治疗结果和资源利用，使政策相关的见解， 治疗和护理。CHERISH（治疗干预卫生经济学中心）的总体目标 物质使用障碍，丙型肝炎病毒和艾滋病毒）是发展和传播经济证据， 药物使用障碍政策以及对药物使用者的丙型肝炎病毒和艾滋病毒护理。在这段时间里，我们 将扩大我们的重点，以结果和实施研究，是在个人，系统和 （1）促进使用来自各社区的人口数据，具体目标如下： 行政和临床记录，以进行社区一级的治疗和护理经济评价 对于物质使用障碍，以及使用物质的人中的HCV和HIV，以及2）促进 模拟建模方法在评估非洲经济和人口结果中的应用 物质使用障碍、HCV和HIV治疗。我们还将利用我们的 独特的专业知识，在多个州机构中处理链接的州一级行政数据， 马萨诸塞州帮助建立在其他州建立和使用类似数据库的最佳做法。我们将 与同事合作，创建并维持一个研究人员网络，这些研究人员使用模拟模型， 为应对阿片类药物危机提供信息。我们将主办年度工作组会议， 确定模拟物质使用障碍和HCV传播的最佳实践的手稿， 注射毒品者中的艾滋病毒感染者，并与传播和政策核心密切合作， 将模拟模型结果转化为可操作的政策信息的实践。

PROJECT SUMMARY: Population Data & Modeling Core (PDMC) At this time, overdose deaths reduce US life expectancy and we are spending more than $500 billion per year on treating substance use disorders and their medical consequences. Considering the wide spectrum of clinical and economic consequences of substance use, the U. faces a “syndemic” of substance use disorder, HIV, HCV, and bacterial infections. In response, we propose to replace the former HCV & HIV Core with a Population Data & Modeling Core (PDMC) that has a broader mission to use secondary data and modeling to address population outcomes of this syndemic. One powerful approach to measuring economic value is using “big data” from the real world. Linked administrative records and data repositories from electronic health records compliment traditional prospective study designs and are an essential tool for health economics research. Administrative and clinical records are still more powerful when coupled to simulation models. Simulation models can integrate the most up-to-date knowledge about the epidemiology and natural history of substance use disorders, treatment outcomes, and resource utilization to make policy-relevant insights about treatment and care. The overall aim of CHERISH (Center for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIV) is to develop and disseminate economic evidence that informs substance use disorder policy and HCV and HIV care of people who use substances. In this renewal period we will expand our focus to outcome and implementation research that is conducted at the individual, system, and community levels with the following specific aims: 1) to promote the use of population data from linked administrative and clinical records in conducting community-level economic evaluations of treatment and care for substance use disorder, and HCV and HIV among people who use substances, and 2) to advance the application of simulation modeling methods to evaluations of the economic and population outcomes of substance use disorder, HCV, and HIV treatment for people who use substances. We will also leverage our unique expertise working with linked state-level administrative data across multiple state agencies in Massachusetts to help establish best practices for building and using similar databases in other states. We will collaborate with colleagues to create and sustain a network of researchers who employ simulation models to inform the response to the opioid crisis. We will sponsor an annual working group meeting, publish manuscripts identifying best practices for simulating substance use disorder and the transmission of HCV and HIV among people who inject drugs, and work closely with the Dissemination & Policy Core to develop best practices for translating simulation model outcomes into actionable policy messages.