Microscopy and Histopathology Core B
显微镜和组织病理学核心 B
基本信息
- 批准号:10378464
- 负责人:
- 金额:$ 22.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-09-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAreaBiologicalBiologyBiomedical ResearchBostonCategoriesClinical ResearchCollaborationsComputers and Advanced InstrumentationConfocal MicroscopyConsultationsCore FacilityDevelopmentDigestive System DisordersElectron MicroscopyEmerging TechnologiesEnsureEpithelialEquipmentExperimental DesignsFacultyFinancial SupportFundingFutureGastrointestinal tract structureGrantHistologyHistopathologyHospitalsHourHumanImageImage AnalysisImaging technologyImmuneInfrastructureInvestigator-Initiated ResearchIsraelLiverLocationMedical centerMetabolismMethodsMicroscopeMicroscopyMissionMucosal ImmunityMucous MembraneMusNational Institute of Diabetes and Digestive and Kidney DiseasesOperative Surgical ProceduresOpticsPaperPathogenesisPathologistPediatric HospitalsProductivityResearchResearch PersonnelResolutionResourcesRodentScienceServicesSiteStructureSurfaceSystemTechniquesTechnologyTrainingTranslational ResearchUnited States National Institutes of HealthUpdateWomanWorkbasecostexperiencegastrointestinalgut microbeshuman diseaseimage processingimmunocytochemistryinnovationinstrumentationinterestmedical schoolsmembermicrobialnanoscalenew technologyprogramsresearch and developmentstem cell biology
项目摘要
Project Summary
The mission of the Microscopy and Histopathology Core B is to provide HDDC members with basic and
advanced microscope equipment, services and training, image processing resources, histology and
histopathology support, and support for experimental design and scientific analysis that are essential for
research in the digestive diseases.
Core B, which is a long-standing component of the HDDC, is a successful collaboration among three
independent imaging-based cores with their own financial structure that are each led by a director. The
three sites are Beth Israel Deaconess Medical Center (Site A), Boston Children’s Hospital (Site B), and
Brigham and Women’s Hospital (Site C). The three core sites are physically close to one another and
unified by a Core Director who oversees the relationship of each satellite core with the HDDC and its
membership. This infrastructure greatly benefits the HDDC membership by providing imaging equipment
and expertise in locations highly populated with HDDC users while also providing options to amplify
investigator-initiated research programs and enable new experimental approaches. This infrastructure
also allows for the successful integration of other Harvard-based core facilities specializing in advanced
instrumentation.
Nine services were offered for Core B in the past 5-year grant cycle with 39 HDDC Principal Members
and 13 Affiliate Members using Core B. Overall Core B recorded on average 4,200 billable service
hours/year and 16,858 total billable hours over the last 4 year grant cycle (2015-2019) with 95 (primary
use), 42 (secondary use), and 1 (tertiary use) original papers emerging from Core B utilization. HDDC
support significantly extended grant dollars by reducing the cost of services by 25% or more for HDDC
members. New innovations and equipment updates in the past grant cycle benefited, in particular, the
electron microscopy and confocal microscopy services and their users.
In the next grant cycle, the same nine services will be offered in Core B with 64 members indicating an
interest in using Core B services. In the advanced microscopy category, one new service in high
resolution 3-D electron microscopy will be available to HDDC members. Discounted services for HDDC
Principal Members will continue to extend grant dollars and priority access for all HDDC members should
facilitate greater productivity with cutting-edge instrumentation and expertise in the next grant cycle.
项目摘要
显微镜和组织病理学核心B的任务是为人类发展委员会成员提供基本和
先进的显微镜设备、服务和培训、图像处理资源、组织学和
组织病理学支持,以及对实验设计和科学分析的支持,这对
消化系统疾病的研究。
核心B是人类发展委员会的一个长期组成部分,是三个国家之间的成功合作
独立的以成像为基础的核心,有自己的财务结构,每个核心都由一名董事领导。这个
三个站点是贝丝以色列女执事医疗中心(站点A)、波士顿儿童医院(站点B)和
布里格姆妇女医院(C点)。这三个核心地点在物理上彼此接近,并且
由一名核心主任统一,该主任负责监督每个卫星核心与人类发展中心及其
会员制。这一基础设施通过提供成像设备极大地有利于HDDC成员
在HDDC用户密集的地区提供专业知识,同时还提供选项以扩大
研究人员发起的研究计划,并支持新的实验方法。这一基础设施
还允许成功地整合哈佛大学的其他核心设施,专门从事高级
仪器仪表。
在过去5年的赠款周期中,为核心B提供了9项服务,其中包括39个人类发展发展中心主要成员
和13个使用Core B的附属会员。总体而言,Core B平均记录了4,200项付费服务
小时/年,在过去4年拨款周期(2015-2019年)内总计16,858小时,其中95小时(主要)
使用)、42份(二次使用)和1份(三次使用)核心B利用产生的原始文件。HDDC
通过将HDDC的服务成本降低25%或更多,支持大幅延长赠款金额
会员。在过去的赠款周期中,新的创新和设备更新尤其受益于
电子显微镜和共聚焦显微镜服务及其用户。
在下一个授予周期中,核心B将提供相同的九项服务,成员表示
对使用Core B服务感兴趣。在高级显微镜类别中,HIGH的一项新服务
HDDC成员将可以使用分辨率3-D电子显微镜。针对HDDC的折扣服务
主要成员将继续延长赠款美元,所有人类发展委员会成员应优先获得
在下一个赠款周期中,利用尖端仪器和专业知识提高生产率。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Susan J Hagen的其他文献
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{{ truncateString('Susan J Hagen', 18)}}的其他基金
Wohlwend High Pressure Freezer for the BIDMC Electron Microscopy Core
适用于 BIDMC 电子显微镜核心的 Wohlwend 高压冷冻机
- 批准号:
8825681 - 财政年份:2015
- 资助金额:
$ 22.87万 - 项目类别:
CONFOCAL MICROSCOPE: NEURODEGENERATION, ALZHEIMER'S DIS
共焦显微镜:神经退行性变、阿尔茨海默病
- 批准号:
7334957 - 财政年份:2006
- 资助金额:
$ 22.87万 - 项目类别:
Confocal Microscope for the BIDMC Imaging Core Facility
BIDMC 成像核心设施的共焦显微镜
- 批准号:
7047106 - 财政年份:2006
- 资助金额:
$ 22.87万 - 项目类别:
CONFOCAL MICROSCOPE: CELL BIOL, SIGNAL TRANSDUCTION, PROTEIN, CYTOPLASMIC LIPID
共焦显微镜:细胞生物学、信号转导、蛋白质、细胞质脂质
- 批准号:
7334959 - 财政年份:2006
- 资助金额:
$ 22.87万 - 项目类别:
CONFOCAL MICROSCOPE: SURGICAL DISEASES, WOUND HEALING
共焦显微镜:外科疾病、伤口愈合
- 批准号:
7334958 - 财政年份:2006
- 资助金额:
$ 22.87万 - 项目类别:
GI MUCOSAL BARRIER IN HEALTH AND SURGICAL DISEASE
健康和外科疾病中的胃肠道粘膜屏障
- 批准号:
6725833 - 财政年份:2003
- 资助金额:
$ 22.87万 - 项目类别:
GI MUCOSAL BARRIER IN HEALTH AND SURGICAL DISEASE
健康和外科疾病中的胃肠道粘膜屏障
- 批准号:
6024412 - 财政年份:1999
- 资助金额:
$ 22.87万 - 项目类别:
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