Gestational weight gain and infant birthweight among Black women: Beyond individual-level factors

黑人女性妊娠期体重增加和婴儿出生体重：超越个人因素

基本信息

批准号：
10387547
负责人：
Suzanne M Hyer
金额：
$ 7.21万
依托单位：
UNIVERSITY OF CENTRAL FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10387547
关键词：
Advanced Practice Nurse Birth Black race Blood Body mass index C-reactive protein COVID-19 pandemic Censuses Characteristics Communities Crime Data Development Disease Enrollment Ensure Environment Environmental Risk Factor Family Fellowship Florida Food Foundations Future Gestational Age Health Health Food Hispanic Housing Individual Infant Infant Health Inflammation Inflammatory Interferon Type II Interleukin-10 Interleukin-4 Interleukin-6 Interleukin-8 Intervention Low Birth Weight Infant Maternal Health Measures Mediating Medical Records Methodology Methods Mission National Institute of Nursing Research Neighborhoods Not Hispanic or Latino Nurse Midwives Nurse Practitioners Nurses Obesity Outcome Parents Pathway interactions Perception Plasma Poverty Pregnancy Premature Birth Questionnaires Reduce health disparities Reporting Research Research Personnel Research Priority Risk Sampling Scientist Small for Gestational Age Infant Supermarket TNF gene Time United States National Institutes of Health Universities Weight Weight Gain Woman black women cohort cytokine depressive symptoms environmental stressor gestational weight gain health disparity high risk improved multi-ethnic neighborhood association pregnant prenatal prepregnancy social social stressor socioeconomic disadvantage systemic inflammatory response therapy development

项目摘要

Project Summary/Abstract Gestational weight gain (GWG) may be a remediable factor in achieving optimal birth outcomes for Black women. Overall, Black women are more likely to be obese (body mass index [BMI] ≥30 kg/m2), at risk for not gaining optimal weight during pregnancy, and delivering an infant of lower birthweight compared with non- Hispanic white and Hispanic women. Black women are also more likely to reside in neighborhoods with higher levels of socioeconomic disadvantage (e.g., poverty), disorder (e.g., vacant housing) and crime, and have limited access to supermarkets and healthy food options compared with whites. Neighborhood environmental stressors (socioeconomic disadvantage, disorder, crime, limited food accessibility) may increase the risk for either inadequate or excessive GWG and lower infant birthweight. However, existing data show inconclusive associations of neighborhood environmental stressors with inadequate or excessive GWG and infant birthweight. Data from 620 pregnant Black women enrolled in the NIH R01 study Social stressors and inflammation: A mixed methods approach to preterm birth (R01MD011575; PI Giurgescu, Co-I Misra) prior to the COVID-19 pandemic will be analyzed. Women completed questionnaires and had blood drawn at 19-29 weeks gestation. Neighborhood environmental stressors and depressive symptoms were measured by maternal questionnaires and administrative (e.g., census) data. Systemic inflammation was assessed by plasma levels of cytokines (interleukin [IL]-4, IL-6, IL-8, IL-10, tumor necrosis factor [TNF-α], interferon gamma [IFN-γ]) and C-Reactive Protein [CRP]. GWG and birth data will be obtained from medical records. The aims of this study are to: 1) Determine the pathways by which neighborhood environmental stressors relate to GWG; and 2) Determine the pathways by which neighborhood environmental stressors relate to infant birthweight. This is the first study to simultaneously examine the relationship of perceived and objectively measured neighborhood environmental stressors with GWG in a large cohort of pregnant Black women. Neighborhood access to healthy and unhealthy food stores will be examined as a health determinant to GWG. In line with the National Institute of Nursing Research’s priorities, this study will identify social and physical determinants of GWG and infant birthweight among Black women. The objectives and specific aims are highly relevant to the mission to promote and improve health individuals, families, and communities. The postdoctoral fellowship will provide a strong foundation on which to build the applicant’s research to ensure adequate GWG and ultimately improve maternal and infant health among Black families. The research environment at University of Central Florida will support the applicant’s development into an independent researcher and nurse scientist. Results will inform future interventions with advanced practice nurses (nurse practitioners, certified nurse midwives) to reduce health disparities in GWG and infant birthweight among Black women.

项目摘要/摘要妊娠体重增加（GWG）可能是实现黑色最佳出生结果的可补救因素女性。总体而言，黑人妇女更有可能肥胖（体重指数[BMI]≥30kg/m2）与非 - 西班牙裔白人和西班牙裔女人。黑人妇女也更有可能居住在较高的社区社会经济障碍（例如贫困），疾病（例如空置住房）和犯罪的水平与白人相比，获得超市和健康食品的选择有限。邻里环境压力源（社会经济障碍，混乱，犯罪，食物可及性有限）可能会增加要么不足或过量的GWG和降低婴儿的出生体重。但是，现有数据显示了不确定的邻里环境压力源与不足或过量的GWG和婴儿的关联出生体重。 NIH R01研究社会压力源的620名孕妇的数据和炎症：早产方法的混合方法（R01MD011575； Pi Giurgescu，Co-I Misra） COVID-19大流行将进行分析。妇女完成了问卷调查，并在19-29中抽血妊娠周。邻里环境压力源和抑郁符号是通过产妇问卷和行政（例如人口普查）数据。全身性炎症由细胞因子的血浆水平（白介素[IL] -4，IL-6，IL-8，IL-10，肿瘤坏死因子[TNF-α]，Interferon Gamma [IFN-γ]）和C反应蛋白[CRP]。 GWG和出生数据将从医疗记录中获得。目的这项研究的是：1）确定邻里环境压力与GWG相关的途径； 2）确定邻里环境压力与婴儿出生体重相关的途径。这是首次简单地检查感知和客观测量的关系的研究在大量怀孕的黑人妇女中，带有GWG的邻里环境压力源。邻里可以将健康和不健康的食品商店作为GWG的健康决定者进行检查。与国家护理研究所的重点，本研究将确定黑人妇女的GWG和婴儿的出生体重。目标和特定目标与促进和改善健康个人，家庭和社区的使命。博士后奖学金将为建立申请人的研究提供了坚实的基础，以确保足够的GWG并最终改善黑人家庭中的孕产妇和婴儿健康。中央大学的研究环境佛罗里达将支持申请人的发展成为独立的研究人员和护士科学家。结果将告知未来与高级执业护士的干预措施（护士，认证护士助产士）减少GWG的健康分布和黑人妇女的婴儿出生体重。