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Gestational weight gain and infant birthweight among Black women: Beyond individual-level factors

黑人女性妊娠期体重增加和婴儿出生体重：超越个人因素

基本信息

批准号：
10576802
负责人：
Suzanne M Hyer
金额：
$ 5.77万
依托单位：
UNIVERSITY OF CENTRAL FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2023-10-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10576802
关键词：
Advanced Practice Nurse Birth Birth Weight Black race Blood Body mass index C-reactive protein COVID-19 pandemic Censuses Characteristics Communities Crime Data Development Disease Enrollment Ensure Environment Environmental Risk Factor Family Fellowship Florida Food Foundations Future Gestational Age Health Health Food High birth weight infant Hispanic Housing Individual Infant Infant Health Inflammation Inflammatory Interferon Type II Interleukin-10 Interleukin-4 Interleukin-6 Interleukin-8 Intervention Low Birth Weight Infant Maternal Health Measures Mediating Medical Records Mentors Methodology Methods Mission National Institute of Nursing Research Neighborhoods Not Hispanic or Latino Nurse Midwives Nurse Practitioners Nurses Obesity Outcome Parents Pathway interactions Perception Plasma Postdoctoral Fellow Poverty Pregnancy Premature Birth Questionnaires Recommendation Reduce health disparities Reporting Research Research Personnel Research Priority Risk Sampling Scientist Small for Gestational Age Infant Supermarket TNF gene United States National Institutes of Health Universities Weight Weight Gain Woman black women cohort cytokine depressive symptoms environmental stressor gestational weight gain health determinants high risk improved multi-ethnic neighborhood association pregnant prenatal prepregnancy social social stressor socioeconomic disadvantage systemic inflammatory response therapy development

项目摘要

Project Summary/Abstract Gestational weight gain (GWG) may be a remediable factor in achieving optimal birth outcomes for Black women. Overall, Black women are more likely to be obese (body mass index [BMI] ≥30 kg/m2), at risk for not gaining optimal weight during pregnancy, and delivering an infant of lower birthweight compared with non- Hispanic white and Hispanic women. Black women are also more likely to reside in neighborhoods with higher levels of socioeconomic disadvantage (e.g., poverty), disorder (e.g., vacant housing) and crime, and have limited access to supermarkets and healthy food options compared with whites. Neighborhood environmental stressors (socioeconomic disadvantage, disorder, crime, limited food accessibility) may increase the risk for either inadequate or excessive GWG and lower infant birthweight. However, existing data show inconclusive associations of neighborhood environmental stressors with inadequate or excessive GWG and infant birthweight. Data from 620 pregnant Black women enrolled in the NIH R01 study Social stressors and inflammation: A mixed methods approach to preterm birth (R01MD011575; PI Giurgescu, Co-I Misra) prior to the COVID-19 pandemic will be analyzed. Women completed questionnaires and had blood drawn at 19-29 weeks gestation. Neighborhood environmental stressors and depressive symptoms were measured by maternal questionnaires and administrative (e.g., census) data. Systemic inflammation was assessed by plasma levels of cytokines (interleukin [IL]-4, IL-6, IL-8, IL-10, tumor necrosis factor [TNF-α], interferon gamma [IFN-γ]) and C-Reactive Protein [CRP]. GWG and birth data will be obtained from medical records. The aims of this study are to: 1) Determine the pathways by which neighborhood environmental stressors relate to GWG; and 2) Determine the pathways by which neighborhood environmental stressors relate to infant birthweight. This is the first study to simultaneously examine the relationship of perceived and objectively measured neighborhood environmental stressors with GWG in a large cohort of pregnant Black women. Neighborhood access to healthy and unhealthy food stores will be examined as a health determinant to GWG. In line with the National Institute of Nursing Research’s priorities, this study will identify social and physical determinants of GWG and infant birthweight among Black women. The objectives and specific aims are highly relevant to the mission to promote and improve health individuals, families, and communities. The postdoctoral fellowship will provide a strong foundation on which to build the applicant’s research to ensure adequate GWG and ultimately improve maternal and infant health among Black families. The research environment at University of Central Florida will support the applicant’s development into an independent researcher and nurse scientist. Results will inform future interventions with advanced practice nurses (nurse practitioners, certified nurse midwives) to reduce health disparities in GWG and infant birthweight among Black women.

项目总结/文摘