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Adolescent drinking and midlife outcomes: A prospective cotwin control study

青少年饮酒与中年结局：一项前瞻性 cotwin 对照研究

基本信息

批准号：
10388266
负责人：
MATTHEW K. MCGUE
金额：
$ 61.35万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-10 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10388266
关键词：
Achievement Acute Address Adolescence Adolescent Adult Age Alcohol consumption Alcohol dependence Alcoholic beverage heavy drinker Alcohols Antisocial Personality Disorder Characteristics Data Data Analyses Deposition Development Disease Education Elderly Environmental Risk Factor Evaluation Family Study Gender Genetic Habits Health behavior Heavy Drinking Individual Instruction Investigation Lead Left Length Life Life Stress Link Literature Long-Term Effects Longitudinal Studies Medical Mental Depression Mental Health Methods Minnesota Modeling Neurocognitive Occupational Outcome Patient Self-Report Pattern Persons Prospective Studies Prospective cohort study Quality of life Research Research Design Research Personnel Risk Risk Factors Role Social Functioning Social isolation Spouses Substance abuse problem Surveys Testing Twin Multiple Birth Twin Studies Woman Youth alcohol poisoning automobile accident behavioral disinhibition binge drinking cognitive function cohort comorbidity course development design drinking early drinking emerging adult experimental study follow-up gender difference high-risk adolescents innovation longitudinal design member men middle age physical conditioning prospective psychosocial public repository sexual victimization social substance use telomere underage drinking

项目摘要

ORIGINAL ABSTRACT Adolescence is a period when many individuals begin to experiment with alcohol, with some progressing rapidly to abusive drinking. The acute problems associated with heavy adolescent alcohol use (e.g., alcohol poisoning, sexual victimization, automobile accidents) have been well documented; less certain is whether adolescent alcohol use also has long-term consequences. Three recent reviews of the relevant literature have come to similar conclusions: adolescent drinking is associated with adult functioning, but the existing literature does not tell us whether these associations are causal or whether the consequences of adolescent drinking are long-lasting. We propose to address these limitations with a prospective study of a unique cohort of twins. These twins were initially assessed at age 17, at the early stages of alcohol use, and again at age 20, the period in adolescence when alcohol use peaks. They were subsequently assessed at ages 24 and 29, a period characterized by life-role transition. We now propose to assess them at mid-life (average age of 42 years), a developmental period characterized by stability and for most a moderation of youthful patterns of heavy drinking. The in-person assessment will cover 4 major domains of functioning: 1) mental health, including substance use and abuse, 2) physical health and behavior, 3) neurocognitive function, and 4) psychosocial outcomes including educational and occupational achievement and relationship quality. We estimate that 1130 twins will participate (greater than 90% of the surviving members of the original cohort) in the in-person assessment and that 910 of their spouses/partners will also complete a brief mail survey. Analysis of the data will document the range of adult outcomes associated with adolescent drinking and evaluate three alternative models to account for these effects: 1) the factors that lead to early and heavy drinking in adolescence also increase the likelihood of deficits in adulthood (i.e., confounding), 2) adolescent heavy drinkers tend to become adult heavy drinkers (i.e., drinking persistence), and 3) adolescent drinking upsets the normal course of adult. The innovative cotwin control design, which controls for genetic and shared environmental factors on outcomes, will help isolate possible causal effects of adolescent drinking on midlife functioning. The extensive earlier assessments of this cohort will provide a wealth of information for propensity score D RELEVANCE (See instructions): The project follows a large cohort of twins from age 17 to age 36-44 to identify the consequences of heavy and abusive drinking in adolescence for functioning in mid-life. The project seeks to determine the extent to which adolescent drinking impacts mental health, physical health, cognitive and social functioning in mid-life and the extent to which any effects can be ameliorated by drinking desistence.

最初的抽象