Adolescent drinking and midlife outcomes: A prospective cotwin control study

青少年饮酒与中年结局：一项前瞻性 cotwin 对照研究

• 批准号: 10388266
• 负责人: MATTHEW K. MCGUE
• 金额: $ 61.35万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-10 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10388266
• 关键词: Achievement; Acute; Address; Adolescence; Adolescent; Adult; Age; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcohols; Antisocial Personality Disorder; Characteristics; Data; Data Analyses; Deposition; Development; Disease; Education; Elderly; Environmental Risk Factor; Evaluation; Family Study; Gender; Genetic; Habits; Health behavior; Heavy Drinking; Individual; Instruction; Investigation; Lead; Left; Length; Life; Life Stress; Link; Literature; Long-Term Effects; Longitudinal Studies; Medical; Mental Depression; Mental Health; Methods; Minnesota; Modeling; Neurocognitive; Occupational; Outcome; Patient Self-Report; Pattern; Persons; Prospective Studies; Prospective cohort study; Quality of life; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Social Functioning; Social isolation; Spouses; Substance abuse problem; Surveys; Testing; Twin Multiple Birth; Twin Studies; Woman; Youth; alcohol poisoning; automobile accident; behavioral disinhibition; binge drinking; cognitive function; cohort; comorbidity; course development; design; drinking; early drinking; emerging adult; experimental study; follow-up; gender difference; high-risk adolescents; innovation; longitudinal design; member; men; middle age; physical conditioning; prospective; psychosocial; public repository; sexual victimization; social; substance use; telomere; underage drinking

ORIGINAL ABSTRACT Adolescence is a period when many individuals begin to experiment with alcohol, with some progressing rapidly to abusive drinking. The acute problems associated with heavy adolescent alcohol use (e.g., alcohol poisoning, sexual victimization, automobile accidents) have been well documented; less certain is whether adolescent alcohol use also has long-term consequences. Three recent reviews of the relevant literature have come to similar conclusions: adolescent drinking is associated with adult functioning, but the existing literature does not tell us whether these associations are causal or whether the consequences of adolescent drinking are long-lasting. We propose to address these limitations with a prospective study of a unique cohort of twins. These twins were initially assessed at age 17, at the early stages of alcohol use, and again at age 20, the period in adolescence when alcohol use peaks. They were subsequently assessed at ages 24 and 29, a period characterized by life-role transition. We now propose to assess them at mid-life (average age of 42 years), a developmental period characterized by stability and for most a moderation of youthful patterns of heavy drinking. The in-person assessment will cover 4 major domains of functioning: 1) mental health, including substance use and abuse, 2) physical health and behavior, 3) neurocognitive function, and 4) psychosocial outcomes including educational and occupational achievement and relationship quality. We estimate that 1130 twins will participate (greater than 90% of the surviving members of the original cohort) in the in-person assessment and that 910 of their spouses/partners will also complete a brief mail survey. Analysis of the data will document the range of adult outcomes associated with adolescent drinking and evaluate three alternative models to account for these effects: 1) the factors that lead to early and heavy drinking in adolescence also increase the likelihood of deficits in adulthood (i.e., confounding), 2) adolescent heavy drinkers tend to become adult heavy drinkers (i.e., drinking persistence), and 3) adolescent drinking upsets the normal course of adult. The innovative cotwin control design, which controls for genetic and shared environmental factors on outcomes, will help isolate possible causal effects of adolescent drinking on midlife functioning. The extensive earlier assessments of this cohort will provide a wealth of information for propensity score D RELEVANCE (See instructions): The project follows a large cohort of twins from age 17 to age 36-44 to identify the consequences of heavy and abusive drinking in adolescence for functioning in mid-life. The project seeks to determine the extent to which adolescent drinking impacts mental health, physical health, cognitive and social functioning in mid-life and the extent to which any effects can be ameliorated by drinking desistence.

原创摘要 青春期是许多人开始尝试饮酒的时期，其中一些人会有所进步 迅速地到滥用饮酒。与青少年大量饮酒有关的严重问题(例如， 酒精中毒、性侵害、车祸)已经有了很好的记录；但不太确定的是 青少年饮酒是否也会产生长期后果。最近对相关的 文献也得出了类似的结论：青少年饮酒与成人的功能有关，但 现有的文献并没有告诉我们这些联系是否有因果关系或其后果 青少年饮酒的风险是长期存在的。我们建议通过一项前瞻性研究来解决这些限制 一群独特的双胞胎。这对双胞胎最初是在17岁时被评估的，当时正值酗酒的早期阶段 使用，在20岁时再次使用，在青春期酒精使用的高峰期。他们随后被 在24岁和29岁时被评估，这是一个以生活角色转换为特征的时期。我们现在建议评估 他们在中年(平均年龄42岁)，这是一个以稳定和大多数人为特征的发育时期 年轻人酗酒模式的缓和。面对面评估将涵盖4个主要领域 功能：1)精神健康，包括药物使用和滥用；2)身体健康和行为；3) 神经认知功能，以及4)包括教育和职业在内的心理社会结果 成就和人际关系质量。我们估计将有1130对双胞胎参加(超过90%的 原始队列中的幸存成员)进行面对面评估，他们的910人 配偶/伴侣还将完成一项简短的邮寄调查。对数据的分析将记录以下范围 与青少年饮酒相关的成人结局并评估三种可供选择的模型来解释 这些影响：1)导致青春期过早酗酒的因素也会增加青少年的 成年期缺陷的可能性(即，令人困惑)，2)青少年酗酒者倾向于成年 酗酒者(即饮酒坚持)，以及3)青少年饮酒扰乱了成年人的正常进程。 创新的双胞胎对照设计，控制遗传和共享的环境因素 结果，将有助于隔离青少年饮酒对中年功能可能的因果影响。这个 对这一队列的广泛早期评估将为倾向评分提供丰富的信息 D 相关性(请参阅说明)： 该项目跟踪了一大批从17岁到36-44岁的双胞胎，以确定 在青春期大量酗酒导致中年功能失调。该项目试图确定 青少年饮酒对心理健康、身体健康、认知和社交的影响程度 中年的功能，以及戒酒可以在多大程度上改善任何影响。