A Longitudinal Study of Adopted Youth and Their Families

描述（由申请人提供）：本申请寻求更新资金，用于对收养和非收养家庭进行独特和创新的纵向研究。兄弟姐妹互动和行为研究（SIBS）包括409个收养家庭和208个非收养家庭。在入院时，每个家庭由一对青春期的兄弟姐妹和他们的抚养父母组成，总共有2394个人。SIBS后代在青春期中期完成了摄入评估，在青春期晚期完成了第一次随访（FU1）评估，并在成年早期完成了第二次随访（FU2）评估。FU1的参与率和迄今为止FU2的参与率远高于90%。摄入和FU评估是广泛的，包括：1)综合评估常见的外化（例如，品行障碍，物质使用障碍，ADHD）和内化（抑郁，焦虑障碍）精神病理学；2)药物使用、滥用和依赖；3)个体层面的风险标记（个性、学业能力和进步）；4)家庭关系（亲子关系、兄弟关系）；5)其他环境风险因素（如同辈群体、宗教信仰、生活压力、邻里关系）。目前的应用程序有4个具体目标：1)完成FU2评估，2)分析FU1和FU2数据以确定常见精神障碍的家族风险性质；3)运用孟德尔随机化原理检验青少年酒精使用和滥用对成年早期心理健康和物质使用障碍风险的影响；4)确定在婴儿期被收养的人成年后患精神障碍的风险是否更高。对SIBS摄入数据的分析表明，这是一项独特的研究，对诸如母亲抑郁的影响、父母反社会行为的影响、青少年酗酒的后果以及美国被收养青少年的心理健康等问题进行了重要观察。对这一研究项目的持续支持将使我们能够绘制出从青春期中期到成年早期常见精神障碍发展的轨迹，采用一种收养设计，使我们能够确定家庭环境和遗传因素对风险的影响。公共卫生相关性：兄弟姐妹互动和行为研究（SIBS）是一项对409个收养家庭和208个非收养家庭的纵向研究，这些家庭的后代从青春期中期到青春期后期到成年早期。这个独特的项目正在确定父母精神病理（例如，母亲抑郁症）对环境的影响，青少年滥用酒精对成年早期心理健康问题的影响，以及作为婴儿被收养的个人在成年后是否有更高的心理健康问题风险。

DESCRIPTION (provided by applicant): This application seeks renewal funding for a unique and innovative longitudinal study of adopted and non-adopted families. The Sibling Interaction and Behavior Study (SIBS) includes 409 adopted and 208 non-adopted families. At intake, each family consisted of pair of adolescent siblings and their rearing parents, a total of 2394 individuals. SIBS offspring have completed an intake assessment in mid-adolescence, a first follow-up (FU1) assessment in late-adolescence, and are in the midst of a second follow-up (FU2) assessment in early adulthood. Rate of participation at FU1 and to date in FU2 is well above 90 percent. Intake and FU assessments are extensive and include: 1) comprehensive assessment of common externalizing (e.g., conduct disorder, substance use disorders, ADHD) and internalizing (depression, anxiety disorders) psychopathology; 2) substance use, abuse, and dependence; 3) individual-level markers of risk (personality, academic ability and progress); 4) family relationships (both parent-offspring and sibling); and 5) other environmental risk factors (e.g., peer group, religiousness, life stress, neighborhood). The current application has 4 specific aims, to: 1) complete the FU2 assessment, 2) analyze FU1 and FU2 data to determine the nature of familial risk for common mental disorders; 3) use the principle of Mendelian Randomization to test the effect of adolescent alcohol use and misuse on risk of mental health and substance use disorders in early adulthood; and 4) determine whether individuals adopted in infancy are at heightened risk for mental disorders as young adults. Analysis of SIBS intake data demonstrates that this is a unique study that is making important observations on, for example, the effect of maternal depression, the impact of parent antisocial behavior, the consequences of adolescent alcohol abuse, and the mental health of US adopted youth. Continued support for this program of research will allow us to chart the trajectory of the development of common mental disorders from mid-adolescence through early adulthood, using an adoption design that allows us to identify familial environmental as well as genetic contributions to risk. PUBLIC HEALTH RELEVANCE: The Sibling Interaction and Behavior Study (SIBS) is a longitudinal study of 409 adoptive and 208 non-adoptive families as the offspring in those families have aged from middle-adolescence through late-adolescence to early adulthood. This unique project is determining the environmental consequences of parent psychopathology (e.g., maternal depression), the effect of adolescent alcohol misuse on early-adult mental health problems, and whether individuals adopted as infants have heightened risk for mental health problems as young adults.