Administrative Core

摘要-行政核心（A） 华盛顿大学圣刘易斯分校（WUSTL）资源中心的长期目标是： 肌肉骨骼生物学和医学（又名，该中心）是为了促进肌肉骨骼研究 为了更好地了解疾病的生物学基础，并开发和测试生物学基础 干预措施。我们代表一个由81名研究人员组成的研究社区，每年资助6600万美元。一 我们的研究社区的优势在于使用动物模型。因此， 中心及其行政核心是支持动物的发展，实施和评估 肌肉骨骼生物学和医学的模型。我们将通过我们的领导层来实现这一目标。 活动和丰富计划。行政核心将通过一个 透明的组织结构。我们将协调中心与我们的研究部门的所有通信 社区和更广泛的WUSTL社区。我们将参加外联活动和伙伴关系 与其他校园中心和计划，以代表肌肉骨骼的研究兴趣。我们将提供 指导和监督研究核心，以确保它们是可访问的，具有成本效益的，并说明- 通过对利用率和性能的定期评估，我们将确保核心 在当地和全国产生巨大影响。自2009年以来，我们已经支持了343篇被引用的出版物 6687次。我们提出了一个多方面的丰富计划，以维持和改善环境， 在WUSTL的肌肉骨骼研究，并促进下一代的发展， 肌肉骨骼研究者通过试点和可行性（P&F）赠款计划，我们将提供种子 资助有潜力建立更大赠款提案的有价值的项目，并提供关键的 支持早期研究者或肌肉骨骼研究新手。自成立以来，P&F 计划获奖者已经获得了21个与其试点赠款相关的工作的外部赠款奖。我们还将 通过研究和教育，为交流新的想法和发现提供了许多机会。 研讨会、专题讨论会和联网活动。最后，我们将支持严格的研究方法， 就小鼠遗传模型的使用以及研究设计和生物统计学提供专家咨询。 总之，我们将为我们的研究社区提供必要的支持，以开发，实施和 评估肌肉骨骼生物学和医学的动物模型，同时促进下一个 肌肉骨骼研究者的一代。

Summary – Administrative Core (A) The long-term goals of the Washington University in Saint Louis (WUSTL) Resource-Based Center for Musculoskeletal Biology and Medicine (a.k.a., the “Center”) are to advance musculoskeletal research towards a better understanding of the biological basis of disease, and to develop and test biologically based interventions. We represent a Research Community of 81 investigators with $66 million in annual funding. A strength of our Research Community is in the use of animal models. Therefore, the overall objective for the Center and its Administrative Core is to support the development, implementation and evaluation of animal models for musculoskeletal biology and medicine. We will pursue this objective through our Leadership activities and Enrichment Program. The Administrative Core will provide leadership of the Center through a transparent organizational structure. We will coordinate all Center communications to our Research Community and the broader WUSTL community. We will participate in outreach activities and partnerships with other campus centers and programs to represent musculoskeletal research interests. We will provide guidance and oversight of the Research Cores to ensure that they are accessible, cost-effective and state- of-the-art. Through regular evaluation of utilization and performance, we will ensure that the Cores have strong impact locally and nationally. Since 2009, we have supported 343 publications that have been cited 6687 times. We propose a multi-faceted Enrichment Program to sustain and enhance the environment for musculoskeletal research at WUSTL, and to foster the development of the next generation of musculoskeletal investigators. Through a Pilot & Feasibility (P&F) Grant Program we will provide seed funding for meritorious projects that have potential to build to larger grant proposals, and that provide critical support to Early Stage Investigators or those new to musculoskeletal research. Since its inception, P&F Program awardees have earned 21 external grant awards on work related to their pilot grants. We will also provide numerous opportunities for exchange of new ideas and findings, through research and educational seminars, symposia and networking events. Lastly, we will support rigorous research approaches by providing expert consulting on the use of mouse genetic models, as well as study design and biostatistics. In summary, we will provide essential support for our Research Community to develop, implement and evaluate animal models for musculoskeletal biology and medicine, while fostering development of the next generation of musculoskeletal investigators.