Longitudinal Analysis of Low pH Streptococci and Plaque Microbiome in Early Childhood Caries
儿童早期龋齿中低 pH 链球菌和菌斑微生物组的纵向分析
基本信息
- 批准号:10388260
- 负责人:
- 金额:$ 53.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-06-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:Acid-Base EquilibriumAgeAreaBacteriaBioinformaticsCarbohydratesChildClinicalDataData AnalysesDental EnamelDental HygieneDental PlaqueDental cariesDevelopmentEcologyElementsEpidemiologyEquilibriumEtiologyExperimental DesignsGenesGenomicsGroupingHealthIntegration Host FactorsIowaLeadLeftLesionLiteratureLongitudinal StudiesMinorityNutritionalOdontogenesisOral cavityOrganismOutcomePathologyPatternPediatric DentistryPhenotypePopulationPreventionPropertyProspective StudiesResearchResearch PriorityRiskRisk AssessmentRoleSamplingScoring MethodSiteStreptococcusStreptococcus Viridans GroupStreptococcus anginosusStreptococcus gordoniiStreptococcus mitisStreptococcus mutansStreptococcus oralisSubgroupTaxonomyTimeUncertaintyUnited States National Institutes of HealthUniversitiesagedalkalinitybasedietaryearly childhoodexhausthealth disparityhigh riskhigh risk populationimplementation scienceimprovedinnovationlongitudinal analysismembermicrobialmicrobiomemicrobiome compositionnovelnovel strategiesoral microbiomeoral plaqueoral streptococcipediatric departmentprospectivesound
项目摘要
ABSTRACT
The microbial etiology of dental caries remains a subject of debate with considerable differences of
opinion regarding the relative contributions of specific species or classes of bacteria. The `low pH streptococci'
is a designation given to atypical, highly acidogenic strains of oral streptococci originally thought to belong to the
primary plaque colonizing species S. oralis, S. mitis, S. gordonii, and S. anginosus. This sub-group of
streptococci is proposed to have considerable cariogenic potential, perhaps preceding, augmenting or even
overshadowing the contribution of the mutans streptococci (MS). However, assessing the role of the low pH
strep is not straightforward. Accurate assignment of species among the viridans streptococci is a challenge, and
the low pH phenotype cannot be ascertained by the gene-based strategies routinely employed in non-culture
based studies of the oral microbiome. In this application we propose a unique prospective study that combines
state-of-the-art bioinformatics with phenotypic analyses of low pH phenotypes to track changes in the plaque
microbiome, with a specific focus on the MS and non-MS low pH streptococci, as caries develop in children at
high risk for early childhood caries. Specifically, our objectives are to determine if there is ascendancy of non-
MS low pH streptococci within the plaque oral microbiome with potential shifts in composition of other organisms
during the transition from a sound enamel site to a carious enamel site. In addition, we propose a novel and
exciting approach of categorizing low pH streptococci based on their potential to produce alkaline products. We
believe that gaining a more comprehensive assessment of the low pH streptococcal species or taxa, and our
novel grouping of these organisms based on alkaline-producing phenotypes, as part of our determination of the
plaque microbiome composition has the potential to make significant contributions to implementation science.
To meet our objectives we propose the following aims: 1) Conduct an 18-month longitudinal study on high-caries
risk children aged 1-3 to determine changes in the overall plaque microbiome preceding caries development,
with a focus on the non-MS low pH streptococci; and 2) Use genomic sequencing to assign species identity or
taxonomical relatedness to the non-MS low pH streptococci recovered in Aim 1. By coalescing and analyzing
the data from the microbiome and low pH streptococci as caries develop we will define patterns or drivers of
caries or health that may provide a basis for advances in implementation science.
摘要
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A Social Media Intervention for Promoting Oral Health Behaviors in Adolescents: A Non-Randomized Pilot Clinical Trial.
- DOI:10.3390/oral3020018
- 发表时间:2023-06
- 期刊:
- 影响因子:0
- 作者:Calderon SJ;Comnick CL;Villhauer A;Marshall T;Dahl JU;Banas JA;Drake DR
- 通讯作者:Drake DR
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Jeffrey A Banas其他文献
Identification and sequence analysis of a methylase gene in Porphyromonas gingivalis.
牙龈卟啉单胞菌甲基化酶基因的鉴定和序列分析。
- DOI:
- 发表时间:
1991 - 期刊:
- 影响因子:14.9
- 作者:
Jeffrey A Banas;Joseph J. Ferretti;Ann Progulske - 通讯作者:
Ann Progulske
Jeffrey A Banas的其他文献
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{{ truncateString('Jeffrey A Banas', 18)}}的其他基金
Probiotics for Prevention of Early Childhood Caries
益生菌预防儿童早期龋齿
- 批准号:
10892707 - 财政年份:2023
- 资助金额:
$ 53.83万 - 项目类别:
Site-Specific Non-Mutans Streptococci Etiologies of Dental Caries
龋齿的位点特异性非变形链球菌病因学
- 批准号:
8278764 - 财政年份:2012
- 资助金额:
$ 53.83万 - 项目类别:
Site-Specific Non-Mutans Streptococci Etiologies of Dental Caries
龋齿的位点特异性非变形链球菌病因学
- 批准号:
8450696 - 财政年份:2012
- 资助金额:
$ 53.83万 - 项目类别:
Streptococcus mutans strain susceptibility differences to host defense peptides
变形链球菌菌株对宿主防御肽的敏感性差异
- 批准号:
7890861 - 财政年份:2010
- 资助金额:
$ 53.83万 - 项目类别:
Streptococcus mutans strain susceptibility differences to host defense peptides
变形链球菌菌株对宿主防御肽的敏感性差异
- 批准号:
8084205 - 财政年份:2010
- 资助金额:
$ 53.83万 - 项目类别:
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