An Analysis of Psychosocial Risk and Protective Factors: Accelerated Cognitive Aging and Mild Traumatic Brain Injury (MTBI) Among Retired NFL & Former NCAA Football Players

心理社会风险和保护因素分析：退役 NFL 加速认知老化和轻度创伤性脑损伤 (MTBI)

• 批准号: 10221561
• 负责人: Robert W. Turner
• 金额: $ 12.25万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221561
• 关键词: Address; Adult; Age; Aging; Alzheimer' s Disease; Applications Grants; Area; Attitude; Awareness; Brain Concussion; Brain Injuries; Brain imaging; Cessation of life; Characteristics; Cognition; Cognitive; Cognitive aging; Collaborations; Control Groups; Data; Demographic Factors; Disease; Elderly; Emergency department visit; Ethnography; Exercise; Exhibits; Exposure to; Focus Groups; Freedom; Frequencies; Gender; Goals; Health; Health Campaign; Health Care Costs; Health Status; Healthcare; Hospitalization; Individual; Injury; Instruction; Interview; Knowledge; Lead; Life; Life Cycle Stages; Manufactured football; Measures; Mediating; Medical; Medical Sociology; Memory impairment; Mental Depression; Mental Health; Mentored Research Scientist Development Award; Mentors; Methods; Modeling; National Institute on Aging; Neurocognitive; Neurodegenerative Disorders; Pain; Pattern; Personal Satisfaction; Population; Portraits; Postdoctoral Fellow; Process; Psychosocial Assessment and Care; Psychosocial Factor; Psychosocial Stress; Public Health; Race; Reading; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Technics; Risk; Risk Factors; Series; Severities; Surveys; Testing; Training; Training Activity; Training Support; United States; Universities; Variant; Veterans; Work; age related; biobehavior; biopsychosocial; brain health; career; career development; chronic depression; chronic pain; chronic traumatic encephalopathy; cognitive function; cognitive process; cohort; college; coping; cost; design; ethnographic method; evidence base; executive function; experience; fitness; health care availability; health care service utilization; health difference; health disparity; improved; indexing; individual variation; innovation; insight; male; men; mild cognitive impairment; mild traumatic brain injury; neuropsychiatry; operation; perceived stress; physical conditioning; protective factors; psychologic; psychosocial; racial and ethnic; sociodemographics

Project Summary/Abstract: Robert W. Turner II is a Research Associate in the Center on Biobehavioral Health Disparities Research at Duke University. He has training in medical sociology, ethnographic methods, and health disparities research as well as a strong commitment to improving the mental health of adult males. His previous and current work has exposed him to theoretical perspectives and empirical approaches pertinent to health disparity and aging research among men. The current proposal is for a five year Mentored Research Scientist Development Award (K01) from the National Institute on Aging for training and support that address gaps in his knowledge of biobehavioral factors underlying mild traumatic brain injury mTBI and accelerated cognitive aging. In collaboration with his mentoring team (Drs. Tim Strauman, Keith Whitfield, and Toni Antonucci) he has developed a comprehensive training and research plan that will both fill in these knowledge gaps and prepare him for an independent research career. The overarching goal of his K01 is to become an expert on the interrelationships between multiple measures of psychosocial and neurocognitive factors associated with accelerated cognitive aging, and serve as bridge for him to establish an independent investigator career in conducting biobehavioral health disparities research in aging adult male populations. To accomplish this goal, he proposes four career development activities and three research aims that combines instruction with established scholars in survey research techniques; formal coursework; participation in ongoing seminars at Duke University; one-to-one directed readings with mentors; and finally, conduction of a “proof of concept study” from start to finish. Preliminary data will be collected with using a mixed-method design that consists of a survey, focus groups, and in-depth interviews. The two research aims will enable him to integrate and apply the knowledge that he will gain through the proposed training activities by creating a more robust overall portrait of psychosocial protective and risk factors that may impact the long-term consequences of mTBI among men than previously possible. The approach used in this project will address; a) male vulnerabilities in predicting the impact of psychosocial factors on accelerated cognitive aging and b) how understandings of masculinity develop across and within groups in relationship to pain, injury, and brain health. This project will continue to build on insights he has gained through his examination of data from the Study of Retired NFL Players. By completing these aims, he will test important hypotheses and make a substantial contribution to the evidence base by describing the process of cognitive accelerated aging resulting from mTBI. This proposal is relevant to public health because it will explore innovative approaches to address functional, cognitive, and psychosocial vulnerabilities in concussed men, and may ultimately reduce the risk of Chronic Traumatic Encephalopathy (CTE), and Alzheimer's disease resulting from concussions. It will also inform an R-series grant proposal to study accelerated cognitive aging and brain imaging that Dr. Turner plans to submit in year 4 of the project.

项目概要/摘要：Robert W.特纳二世是该中心的研究助理， 杜克大学的生物行为健康差异研究。他受过医学社会学的训练， 民族志方法和健康差异研究，以及对改善 成年男性的心理健康。他以前和现在的工作使他接触到理论 观点和经验方法有关的健康差距和老龄化研究的男子。 目前的建议是由五年指导研究科学家发展奖（K 01） 国家老龄化研究所的培训和支持，以解决他的生物行为知识的差距 轻度创伤性脑损伤mTBI和加速认知老化的潜在因素。合作 与他的指导团队（蒂姆·斯特劳曼博士、基思·惠特菲尔德博士和托尼·安东努奇博士）一起，他开发了一种 一个全面的培训和研究计划，既可以填补这些知识空白， 从事独立的研究工作。他的K 01的首要目标是成为一个专家， 心理社会和神经认知因素的多项测量之间的相互关系 加速认知老化，并为他建立一个独立的调查员， 从事老年男性人群生物行为健康差异研究。到 为了实现这一目标，他提出了四项职业发展活动和三个研究目标， 结合教学与既定的学者在调查研究技术;正式的课程; 参与杜克大学正在进行的研讨会;与导师一对一的指导阅读;以及 最后，从头到尾进行“概念验证研究”。将收集初步数据 使用由调查、焦点小组和深入访谈组成的混合方法设计。的 两个研究目标将使他能够整合和应用他将通过 拟议开展的培训活动， 可能影响男性mTBI长期后果的因素比以前可能的要多。的 本项目采用的方法将解决：a）男性在预测 加速认知老化的社会心理因素和B）对男性气质的理解如何发展 与疼痛、损伤和大脑健康的关系。该项目将继续 建立在他通过对退役NFL球员研究的数据进行检查而获得的见解之上。 通过完成这些目标，他将测试重要的假设，并作出重大贡献， 通过描述mTBI导致认知加速老化的过程，建立了证据基础。这 该提案与公共卫生有关，因为它将探索创新方法， 认知和心理社会脆弱性，并可能最终降低风险， 慢性创伤性脑病（CTE）和脑震荡引起的阿尔茨海默病。它将 还通知R系列拨款建议，研究加速认知老化和大脑成像，博士。 特纳计划在项目的第四年提交。