The Contribution of Repetitive Head Impacts and Social Determinants of Health to Alzheimer's Disease and Related Dementia in Older Adult Black Men
重复性头部撞击和健康的社会决定因素对老年黑人阿尔茨海默病和相关痴呆症的影响
基本信息
- 批准号:10740485
- 负责人:
- 金额:$ 129.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-15 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerometerAdultAffectAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmericanAmyloid beta-ProteinAtrophicBiological AssayBiological MarkersBlack AmericanBlack PopulationsBlack raceBloodBostonBrainCerebrospinal FluidChildhoodCognitionCognitiveCollaborationsDataData SetDetectionDiagnosisDiffusionDiseaseDisparityDoseEconomicsEducationElderlyEnrollmentEnvironmentEquationExposure toFaceFrequenciesGoalsHealthHippocampusImpaired cognitionIndividualLate EffectsLifeLightLinkMagnetic Resonance ImagingManufactured footballMediatingModelingNeighborhoodsNerve DegenerationNeurobehavioral ManifestationsNeurodegenerative DisordersNeurologicNeurological outcomeOutcomeParticipantPathway interactionsPhenX ToolkitPlasmaPlayPositioning AttributePovertyProteinsPublishingQuestionnairesResearchResistanceRiskRisk FactorsRoleSeveritiesSurveysTauopathiesTestingTraumatic Brain InjuryUnderrepresented PopulationsUniversitiesWashingtonWellness ProgramWhite Matter Hyperintensityadverse childhood eventsblack menbrain healthchronic traumatic encephalopathycognitive functioncontact sportsdosageeducation accessexperiencehead impacthealth care availabilityhealth care qualityindexinginstrumentmennervous system disorderneurofilamentneuropsychiatric symptomneuropsychiatryracial disparityracial identityrecruitresilienceresponsesocial factorssocial health determinantstau-1white matter
项目摘要
ABSTRACT. Black Americans face nearly double the risk of Alzheimer’s disease (AD) and related
compared to Whites. Black American men may be at increased risk for late-life neurological disorders associated
with exposure to repetitive head impacts (RHI) and traumatic brain injury (TBI) from contact sports participation
and other risk factors. Exposure to RHI/TBI is linked with late-life cognitive impairment, neuropsychiatric
disturbances, and structural brain changes. Black racial identity and exposure to RHI/TBI has been shown to
have an additive effect on MRI metrics of atrophy and cerebrospinal fluid neurodegenerative disease proteins.
These neurological disparities might be explained by social determinants of health (SDOH) (e.g., education
access and quality, health care access and quality, neighborhood environment), which might affect resistance
and resilience to other neurological disorders from RHI/TBI. SDOH factors might indeed contribute to
neurological outcomes in adult Black men irrespective of RHI/TBI. Yet, there has been persistent under-
representation of Blacks in biomedical and health research, including among studies of the late effects
of RHI from American football play. The overarching goal of this study is to examine the impact of RHI/TBI
from American football and the contribution of early-life SDOH to later-life cognitive function, neuropsychiatric
symptoms, structural MRI features, and plasma biomarkers in Black male former American football athletes and
non-RHI/TBI exposed Black men. We will recruit 100 Black male former American football athletes (across all
levels of play and cognitive continuum, 50+ years) and 100 age-matched Black males without RHI/TBI.
Participants will enroll to complete harmonized cognitive and neuropsychiatric tests, MRI, and blood draw to
assess neurodegenerative disease proteins. A battery of questionnaires (e.g., Adverse Childhood Experiences,
Childhood-Experiences Survey, SHARELIFE survey) will be administered to assess SDOH. In Aim 1, we will
investigate the association between RHI/TBI and later-life cognitive and neuropsychiatric symptoms in Black
male former American football athletes. Aim 2 will investigate the association between RHI/TBI and later-life
biomarkers of Aß, p-tau, and neurodegeneration outcomes in Black male former American football athletes. Aim
3 will examine the contribution of SDOH to later-life cognitive and neuropsychiatric symptoms and later-life
biomarkers of Aß, p-tau, and neurodegeneration outcomes. Our hypotheses are that (1) RHI/TBI will be
associated with worse cognitive and neuropsychiatric function and compromised structural gray/white matter in
Black former football players; (2) impoverished SDOH will increase risk and reduce resilience to the late-life
effects of RHI/TBI; and (3) impoverished SDOH will mediate the effects of RHI on late-life neurological outcomes.
This R01 will discover the role of RHI/TBI and SDOH in older Black men. We will address racial disparities
present in data on late life neurological outcomes from RHI/TBI to facilitate accurate disease detection and
diagnosis at the individual-level.
摘要。美国黑人患阿尔茨海默病(AD)及相关疾病的风险几乎是美国黑人的两倍。
与白人相比。美国黑人男性可能会增加晚年神经系统疾病的风险
暴露于重复性头部撞击(RHI)和接触性运动引起的创伤性脑损伤(TBI)
和其他风险因素。暴露于RHI/TBI与晚年认知障碍、神经精神障碍有关。
干扰和大脑结构变化。黑人种族身份和暴露于RHI/TBI已被证明,
对萎缩和脑脊液神经退行性疾病蛋白的MRI指标具有累加效应。
这些神经学差异可以用健康的社会决定因素(SDOH)来解释(例如,教育
可获得性和质量、卫生保健可获得性和质量、社区环境),这可能会影响耐药性
以及对RHI/TBI引起的其他神经系统疾病的适应能力。SDOH因素可能确实有助于
成年黑人男性的神经系统结局,与RHI/TBI无关。然而,一直以来,
黑人在生物医学和健康研究中的代表性,包括在后期影响研究中的代表性
美国橄榄球比赛中的RHI本研究的总体目标是检查RHI/TBI的影响
从美式足球和早期生活的SDOH的贡献,以后的生活认知功能,神经精神
前美国橄榄球运动员黑人男性的症状、结构MRI特征和血浆生物标志物,
非RHI/TBI暴露的黑人男性。我们将招募100名黑人男性前美国足球运动员(在所有
游戏水平和认知连续性,50岁以上)和100名年龄匹配的黑人男性没有RHI/TBI。
受试者将入组完成统一的认知和神经精神测试、MRI和抽血,
评估神经退行性疾病蛋白。一组调查问卷(例如,不良童年经历,
将进行童年经历调查、SHARELIFE调查)以评估SDOH。在目标1中,我们
调查黑人RHI/TBI与晚年认知和神经精神症状之间的关系
前美国橄榄球运动员目的2将研究RHI/TBI与晚年生活的关系
黑人男性前美式橄榄球运动员中的ApoE、p-tau和神经变性结果的生物标志物。目的
3将检查SDOH对晚年认知和神经精神症状以及晚年生活的贡献。
生物标志物的Ablation,p-tau和神经退行性疾病的结果。我们的假设是(1)RHI/TBI将是
与认知和神经精神功能恶化以及结构性灰质/白色物质受损相关,
黑人前足球运动员;(2)贫困的SDOH将增加风险并降低对晚年的适应力
RHI/TBI的影响;(3)贫困的SDOH将介导RHI对晚年神经系统结局的影响。
这个R 01将发现RHI/TBI和SDOH在老年黑人男性中的作用。我们将解决种族不平等问题
在RHI/TBI的晚期神经学结局数据中呈现,以促进准确的疾病检测,
个人层面的诊断。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert W. Turner其他文献
Substance Use Among Collegiate Athletes Versus Non-athletes
大学运动员与非运动员的药物使用情况
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
J. Charest;M. Grandner;A. Athey;D. McDuff;Robert W. Turner - 通讯作者:
Robert W. Turner
Preaching to the choir? Heterogeneous responses to environmental images
向唱诗班说教?对环境图像的不同反应
- DOI:
10.1007/s13412-022-00801-w - 发表时间:
2022-10-17 - 期刊:
- 影响因子:2.300
- 作者:
Robert W. Turner - 通讯作者:
Robert W. Turner
Submarine Communication Antenna Systems
- DOI:
10.1109/jrproc.1959.287241 - 发表时间:
1959-05 - 期刊:
- 影响因子:0
- 作者:
Robert W. Turner - 通讯作者:
Robert W. Turner
Lifetime stressful experiences and cognitive performance in African American and white older adults: New evidence from a population‐based cohort
非裔美国人和白人老年人的终生压力经历和认知表现:来自人群队列的新证据
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
M. Zuelsdorff;A. Sonnega;D. Byrd;S. F. Benton;Robert W. Turner - 通讯作者:
Robert W. Turner
Reported Sports Participation, Sex, and Obesity in a Nationally Representative Sample
- DOI:
10.1016/j.jadohealth.2013.10.173 - 发表时间:
2014-02-01 - 期刊:
- 影响因子:
- 作者:
Robert W. Turner;Asheley Cockrell Skinner;Eliana M. Perrin;Camila Peterson;Tamera Coyne-Beasley - 通讯作者:
Tamera Coyne-Beasley
Robert W. Turner的其他文献
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{{ truncateString('Robert W. Turner', 18)}}的其他基金
An Analysis of Psychosocial Risk and Protective Factors: Accelerated Cognitive Aging and Mild Traumatic Brain Injury (MTBI) Among Retired NFL & Former NCAA Football Players
心理社会风险和保护因素分析:退役 NFL 加速认知老化和轻度创伤性脑损伤 (MTBI)
- 批准号:
9754726 - 财政年份:2018
- 资助金额:
$ 129.35万 - 项目类别:
An Analysis of Psychosocial Risk and Protective Factors: Accelerated Cognitive Aging and Mild Traumatic Brain Injury (MTBI) Among Retired NFL & Former NCAA Football Players
心理社会风险和保护因素分析:退役 NFL 加速认知老化和轻度创伤性脑损伤 (MTBI)
- 批准号:
10600218 - 财政年份:2018
- 资助金额:
$ 129.35万 - 项目类别:
Black Male Dementia Caregiver Burden: Stress-related Cognitive Dysfunction, and physiological and psychosocial measures
黑人男性痴呆症护理人员负担:压力相关的认知功能障碍以及生理和心理社会措施
- 批准号:
9928195 - 财政年份:2018
- 资助金额:
$ 129.35万 - 项目类别:
An Analysis of Psychosocial Risk and Protective Factors: Accelerated Cognitive Aging and Mild Traumatic Brain Injury (MTBI) Among Retired NFL & Former NCAA Football Players
心理社会风险和保护因素分析:退役 NFL 加速认知老化和轻度创伤性脑损伤 (MTBI)
- 批准号:
10221561 - 财政年份:2018
- 资助金额:
$ 129.35万 - 项目类别:
An Analysis of Psychosocial Risk and Protective Factors: Accelerated Cognitive Aging and Mild Traumatic Brain Injury (MTBI) Among Retired NFL & Former NCAA Football Players
心理社会风险和保护因素分析:退役 NFL 加速认知老化和轻度创伤性脑损伤 (MTBI)
- 批准号:
9385633 - 财政年份:2017
- 资助金额:
$ 129.35万 - 项目类别:
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