An Analysis of Psychosocial Risk and Protective Factors: Accelerated Cognitive Aging and Mild Traumatic Brain Injury (MTBI) Among Retired NFL & Former NCAA Football Players

心理社会风险和保护因素分析：退役 NFL 加速认知老化和轻度创伤性脑损伤 (MTBI)

• 批准号: 10600218
• 负责人: Robert W. Turner
• 金额: $ 12.2万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10600218
• 关键词: Address; Administrative Supplement; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Applications Grants; Awareness; Brain Concussion; Brain Injuries; Brain imaging; COVID-19 pandemic; Clinical Research; Cognitive; Cognitive aging; Collaborations; Dementia; Development Plans; Goals; Health; Health Campaign; Individual; Injury; Instruction; Knowledge; Leadership; Life; Manufactured football; Measures; Mentored Research Scientist Development Award; Mentors; Neurocognitive; Pain; Portraits; Process; Psychosocial Factor; Public Health; Research; Research Technics; Risk; Risk Factors; Scientist; Series; Societies; Surveys; Testing; Training; Training Activity; Training Support; United States; Universities; Washington; biobehavior; brain health; career; career development; chronic traumatic encephalopathy; cost; evidence base; experience; innovation; male; men; mild traumatic brain injury; professor; protective factors; psychosocial

Project Summary/Abstract: Robert W. Turner II is an Assistant Professor in the Department of Clinical Research and Leadership at George Washington University (GW), and a Research Scientist in the Center on Health and Society at Duke University. The current proposal is for a one-year administrative supplement to his Mentored Research Scientist Development Award (1K01AG054762-01A1) from NIA for training and support that address gaps in his knowledge of biobehavioral factors underlying Alzheimer’s Disease (AD) related to mild traumatic brain injury (mTBI) and accelerated cognitive aging. As a result of unforeseen issues related to the COVID-19 pandemic, Dr. Turner experienced significant disruption to his scientific and career development plan. In collaboration with his mentors he has developed a comprehensive training and research plan that will both fill in these knowledge gaps and prepare him for an independent research career. The overarching goal of his K01 is to gain expertise on the interrelationships between multiple measures of psychosocial and neurocognitive factors associated with AD dementia related to accelerated cognitive aging. To accomplish this goal, he proposes to continue working on three career development activities and three research aims that combines instruction with established scholars in survey research techniques; one-to-one individualized trainings with mentors; and finally, conducting of a “proof of concept study” from start to finish. The three research aims will enable him to integrate and apply knowledge gained through the proposed training activities by creating a more robust portrait of psychosocial protective and risk factors that may impact the long-term consequences of mTBI among men than previously possible. The approach used in this project will address; a) male vulnerabilities in predicting the impact of psychosocial factors on accelerated cognitive aging and b) how understandings of masculinity develop across and within groups in relationship to pain, injury, and brain health. By completing these aims, he will test important hypotheses and make substantial evidence-based contributions to describing the process of dementia related cognitive accelerated aging resulting from mTBI. This proposal is relevant to public health because it will explore innovative approaches to address functional, cognitive, and psychosocial vulnerabilities in concussed men, and may ultimately reduce the risk of Chronic Traumatic Encephalopathy (CTE), and Alzheimer’s disease resulting from concussions. It will also inform an R-series grant proposal to study mTBI related accelerated cognitive aging and brain imaging that Dr. Turner plans to submit in the final year of the project.

项目概要/摘要： Robert W. Turner II是乔治临床研究和领导系的助理教授 华盛顿大学（GW）和杜克大学健康与社会中心的研究科学家。 目前的建议是为他的指导研究科学家提供为期一年的行政补充 获得NIA的发展奖（1 K 01 AG 054762 - 01 A1），以表彰为解决其 轻度创伤性脑损伤相关的阿尔茨海默病（AD）的生物行为因素的知识 （mTBI）和加速认知老化。由于与COVID-19疫情有关的不可预见问题， 博士特纳的科学和职业发展计划受到了严重干扰。在 他与导师合作，制定了一个全面的培训和研究计划， 这些知识差距，并准备他的独立研究生涯。K 01的首要目标是 获得关于心理社会和神经认知因素的多种测量之间的相互关系的专业知识 与认知老化加速相关的AD痴呆症相关。为了实现这一目标，他建议 继续致力于三个职业发展活动和三个研究目标，将教学与 在调查研究技术方面建立了学者;与导师进行一对一的个性化培训;最后， 从开始到结束进行“概念验证研究”。这三个研究目标将使他能够整合 并通过创建一个更强大的画像， 可能影响男性mTBI长期后果的心理社会保护和风险因素， 以前可能的。本项目采用的方法将解决：a）男性在预测影响方面的脆弱性 社会心理因素对加速认知老化的影响，以及B）对男性气质的理解如何在不同年龄段发展 以及与疼痛、损伤和大脑健康相关的群体内。通过完成这些目标，他将测试重要的 假设，并作出实质性的证据为基础的贡献，以描述痴呆相关的过程 mTBI导致的认知加速老化。这项建议与公共卫生有关，因为它将探讨 创新的方法来解决脑震荡男性的功能，认知和心理社会脆弱性， 可能最终降低慢性创伤性脑病（CTE）和阿尔茨海默病的风险， 脑震荡它还将告知R系列拨款提案，以研究mTBI相关的加速认知老化 以及特纳博士计划在项目最后一年提交的大脑成像。

项目成果

The Price of Playing Through Pain: The Link Between Physical and Behavioral Health in Former NFL Athletes.

• DOI: 10.1177/1557988320975541
• 发表时间: 2020-11
• 期刊: American journal of men's health
• 作者: Bush E;Cupery T;Turner RW 2nd;Sonnega A;Weir D;Whitfield KE;Jackson JS
• 通讯作者: Jackson JS

Positive Effects of Religion and Social Ties on the Health of Former NFL Athletes.

宗教和社会关系对前 NFL 运动员健康的积极影响。

• DOI: 10.1007/s10943-021-01338-y
• 发表时间: 2023
• 期刊: Journal of religion and health
• 影响因子: 2.8
• 作者: Cupery,Tim;Bush,Evelyn;Turner,RobertW;Sonnega,Amanda;Rosales,Teri;Vissa,Kalpana;Whitfield,KeithE;Jackson,JamesS;Weir,David
• 通讯作者: Weir,David