NeMO Archive: SCORCH Support, Coordination and Outreach

NeMO 档案：SCORCH 支持、协调和外展

• 批准号: 10224944
• 负责人: TIMOTHY L TICKLE
• 金额: $ 138.18万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10224944
• 关键词: Archives; Atlases; BRAIN initiative; Binding Sites; Brain; Brain Diseases; Cells; Chromatin; Cloud Computing; Communities; Computer software; Cytosine; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Management Resources; Data Set; Data Storage and Retrieval; Databases; Deposition; Documentation; Educational workshop; Ensure; Environment; Evaluation; FAIR principles; Familiarity; Funding; Generations; Genetic Transcription; Genomic Segment; Goals; HIV; Institution; Internet; Link; Location; Logistics; Maryland; Metadata; Modeling; Modification; Molecular; Multiomic Data; National Institute of Drug Abuse; Neurologic; Neurosciences; Opioid; Pathway Analysis; Pattern; Policies; Practice Management; Publications; Quality Control; Regulatory Element; Research; Research Personnel; Research Project Grants; Resources; Risk; Substance Use Disorder; System; United States National Institutes of Health; Universities; Visualization; Work; base; brain abnormalities; brain research; cell type; cloud based; computerized data processing; data archive; data centers; data dissemination; data ecosystem; data framework; data ingestion; data portal; data repository; data resource; data submission portal; epigenomics; experience; federated computing; histone modification; indexing; member; multiple data types; multiple omics; next generation; operation; outreach; programs; public repository; response; single cell analysis; tool; transcription factor; user-friendly; web site; webinar; working group

SUMMARY We propose to set up a data coordination center to analyze single cell and other molecular data sets generated by Single Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects. This project will leverage our Neuroscience Multi-Omic Data Archive which will host most of the BRAIN initiative multi-omic data (NeMO Archive; R24MH114788) and represents several key existing resources for data management, integration and web presentation tools developed by the University of Maryland group. The Principle Investigator, Co-investigators, and staff of this project have diverse expertise required to marshall data across the SCORCH project consortium, including experience in data collection from multiple institutions, large-scale quality control and analysis processing capability, familiarity with NIH policy, and direct experience with public archive deposition strategies. Activities will be organized around the NeMO Archive, a data repository that is specifically focused on the storage and dissemination of `omic data from the BRAIN Initiative and related brain research projects. We will utilize a federated model for data storage such that the physical location of data can be distributed between the NeMO local file system, public repositories, and the Broad cloud computing environment. The NeMO-SCORCH data center will be fully consistent with the principles advanced by research community members who are launching resources in next generation NIH data ecosystem. These practices include FAIR Principles, documentation of APIs, data-indexing systems, workflow sharing, use of shareable software pipelines, and centralized storage on cloud-based systems. The information incorporating into the NeMO-SCORCH data center will, in part, enable understanding of 1) genomic regions associated with brain abnormalities and disease; 2) transcription factor binding sites and other regulatory elements; 3) transcription activity; 4) levels of cytosine modification; and 5) histone modification profiles and chromatin accessibility.

总结