NeMO Archive: SCORCH Support, Coordination and Outreach

NeMO 档案：SCORCH 支持、协调和外展

• 批准号: 10685258
• 负责人: TIMOTHY L TICKLE
• 金额: $ 134.14万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10685258
• 关键词: Archives; Atlases; BRAIN initiative; Binding Sites; Brain; Brain Diseases; Cells; Chromatin; Cloud Computing; Communities; Computer software; Cytosine; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Management Resources; Data Set; Data Storage and Retrieval; Databases; Deposition; Documentation; Educational workshop; Ensure; Environment; Evaluation; FAIR principles; Familiarity; Funding; Generations; Genetic Transcription; Genomic Segment; Goals; HIV; Institution; Internet; Link; Location; Logistics; Maryland; Metadata; Modeling; Modification; Molecular; Multiomic Data; National Institute of Drug Abuse; Neurologic; Neurosciences; Opioid; Pathway Analysis; Pattern; Policies; Practice Management; Publications; Quality Control; Regulatory Element; Research; Research Personnel; Research Project Grants; Resources; Substance Use Disorder; System; United States National Institutes of Health; Universities; Visualization; Work; brain abnormalities; brain research; cell type; cloud based; computerized data processing; data archive; data centers; data dissemination; data ecosystem; data framework; data ingestion; data portal; data repository; data resource; data submission portal; epigenomics; experience; federated data; histone modification; indexing; member; multiple data types; multiple omics; next generation; operation; outreach; programs; public repository; response; risk mitigation; single cell analysis; tool; transcription factor; user-friendly; web site; webinar; working group

SUMMARY We propose to set up a data coordination center to analyze single cell and other molecular data sets generated by Single Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects. This project will leverage our Neuroscience Multi-Omic Data Archive which will host most of the BRAIN initiative multi-omic data (NeMO Archive; R24MH114788) and represents several key existing resources for data management, integration and web presentation tools developed by the University of Maryland group. The Principle Investigator, Co-investigators, and staff of this project have diverse expertise required to marshall data across the SCORCH project consortium, including experience in data collection from multiple institutions, large-scale quality control and analysis processing capability, familiarity with NIH policy, and direct experience with public archive deposition strategies. Activities will be organized around the NeMO Archive, a data repository that is specifically focused on the storage and dissemination of `omic data from the BRAIN Initiative and related brain research projects. We will utilize a federated model for data storage such that the physical location of data can be distributed between the NeMO local file system, public repositories, and the Broad cloud computing environment. The NeMO-SCORCH data center will be fully consistent with the principles advanced by research community members who are launching resources in next generation NIH data ecosystem. These practices include FAIR Principles, documentation of APIs, data-indexing systems, workflow sharing, use of shareable software pipelines, and centralized storage on cloud-based systems. The information incorporating into the NeMO-SCORCH data center will, in part, enable understanding of 1) genomic regions associated with brain abnormalities and disease; 2) transcription factor binding sites and other regulatory elements; 3) transcription activity; 4) levels of cytosine modification; and 5) histone modification profiles and chromatin accessibility.

总结 我们建议成立一个数据协调中心，分析产生的单细胞和其他分子数据集 艾滋病毒背景下的单细胞阿片样物质反应（SCORCH）和其他NIDA资助的艾滋病毒和物质 使用无序项目。该项目将利用我们的神经科学多器官数据档案，其中将托管大多数 的BRAIN倡议多组学数据（NeMO档案; R24 MH 114788），并代表了几个关键的现有 资源的数据管理，集成和网络演示工具开发的大学 马里兰州集团。本项目的主要研究者、合作研究者和工作人员具有不同的专业知识 要求在SCORCH项目联合体中马歇尔数据，包括从 多个机构，大规模质量控制和分析处理能力，熟悉NIH政策， 和公共档案存放策略的直接经验。将围绕NeMO组织活动 Archive，一个数据存储库，专门关注来自 BRAIN Initiative和相关的大脑研究项目。我们将使用联邦模型进行数据存储， 数据的物理位置可以分布在NeMO本地文件系统，公共存储库， 以及Broad云计算环境。NeMO-SCORCH数据中心将完全符合 在下一代NIH中启动资源的研究社区成员提出的原则 数据生态系统这些实践包括公平原则，API文档，数据索引系统， 工作流共享、可共享软件管道的使用以及基于云的系统上的集中存储。的 纳入NeMO-SCORCH数据中心的信息将部分地使人们能够理解1） 与脑异常和疾病相关的基因组区域; 2）转录因子结合位点， 其他调节元件; 3）转录活性; 4）胞嘧啶修饰水平;和5）组蛋白 修饰谱和染色质可及性。