Gnotobiology Core
知识生物学核心
基本信息
- 批准号:10227104
- 负责人:
- 金额:$ 29.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-06 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAdultAnimalsBacteriaCollectionDerivation procedureEngineeringEnsureGenerationsGenetic EngineeringGerm-FreeGnotobioticHealthHousingIndividualKnowledgeLarvaLifeMethodologyMethodsMicrobeMissionModelingProgram Research Project GrantsQuality ControlResearchResearch Project GrantsScienceSystemTimeVertebratesZebrafishbacterial geneticsdesignexperimental studygenetic manipulationimprovedinnovationmicrobialmicrobiotasuccesstransmission process
项目摘要
PROJECT SUMMARY/ABSTRACT (GNOTOBIOLOGY CORE)
Gnotobiology (meaning “known life”) is the science of animals that are devoid of microbes (germ-free) or
associated with defined microbial consortia. Experiments involving gnotobiotic zebrafish are central to each of
the Research Projects of this Program Project Grant. The Gnotobiology Core provides the expertise necessary
to ensure that experiments described in this proposal are carried out with maximal efficiency and minimal
unnecessary use of vertebrate animals. Beyond ensuring that established methods of germ-free derivation and
gnotobiotic experimentation are implemented to guarantee the highest level of quality control, the
Gnotobiology Core will carry out research that extends the limits of our current gnotobiotic husbandry
methodologies. These research objectives include extending the period of time over which germ-free zebrafish
can be maintained, developing new ways to co-house zebrafish to control the inter-individual transmission of
their microbes, and increasing the range and type of experiments that can be performed with zebrafish-
associated microbes through developing and implementing new genetic engineering strategies in bacteria.
Achieving these objectives will significantly enhance the ability to carry out experiments described in the
Research Projects.
项目摘要/摘要(生物核心)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JUDITH S EISEN其他文献
JUDITH S EISEN的其他文献
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{{ truncateString('JUDITH S EISEN', 18)}}的其他基金
Identification of bacterial products required for brain development
鉴定大脑发育所需的细菌产物
- 批准号:
9807763 - 财政年份:2019
- 资助金额:
$ 29.32万 - 项目类别:
NICHD R25 Summer Research Program at the University of Oregon
俄勒冈大学 NICHD R25 夏季研究项目
- 批准号:
8459523 - 财政年份:2011
- 资助金额:
$ 29.32万 - 项目类别:
NICHD R25 Summer Research Program at the University of Oregon
俄勒冈大学 NICHD R25 夏季研究项目
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8660316 - 财政年份:2011
- 资助金额:
$ 29.32万 - 项目类别:
NICHD R25 Summer Research Program at the University of Oregon
俄勒冈大学 NICHD R25 夏季研究项目
- 批准号:
8217333 - 财政年份:2011
- 资助金额:
$ 29.32万 - 项目类别:
NICHD R25 Summer Research Program at the University of Oregon
俄勒冈大学 NICHD R25 夏季研究项目
- 批准号:
8298973 - 财政年份:2011
- 资助金额:
$ 29.32万 - 项目类别:
NICHD R25 Summer Research Program at the University of Oregon
俄勒冈大学 NICHD R25 夏季研究项目
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10080099 - 财政年份:2011
- 资助金额:
$ 29.32万 - 项目类别:
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7433639 - 财政年份:2008
- 资助金额:
$ 29.32万 - 项目类别:
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