University of Oregon Animal Resource Improvements

俄勒冈大学动物资源改善

• 批准号: 7433639
• 负责人: JUDITH S EISEN
• 金额: $ 48.33万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2010-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7433639
• 关键词: Animal Husbandry; Animal Model; Condition; Corrosion; Development; Disease; Ensure; Equipment; Gasterosteidae; Germ-Free; Health; Hereditary Disease; Housing; Modeling; Monitor; Numbers; Oregon; Procedures; Research; Resistance; Role; Universities; Zebrafish; animal resource; design; gastrointestinal bacteria; genetic evolution; human disease; improved; programs; success

DESCRIPTION (provided by applicant): The aim of this proposal is to improve animal husbandry in the University of Oregon's zebrafish and stickleback facilities. The University is a world-leader in establishing zebrafish and stickleback as model organisms for research in vertebrate development, genetics and evolution. More recently the University has begun to focus on using zebrafish as a model for specific human diseases, including genetic diseases and diseases that may result from interactions with gastrointestinal bacteria. The success of the zebrafish and stickleback research programs at the University of Oregon has resulted in a shortage of aquaria, the need for an improved procedure room and the need for additional monitoring equipment to ensure environmental stability. This application proposes the following aims to rectify these situations: To meet the increasing demand for zebrafish aquaria, we propose to replace many of our old, dilapidated racks with high-capacity racks. This will significantly increase the number of zebrafish we can house and provide more corrosion resistant and ergonomically-designed housing. To improve our ability to study the role of gastrointestinal bacteria in gut development and function, we propose to renovate a zebrafish procedure room. This will significantly upgrade our ability to produce and study germ free zebrafish reared in the absence of gastrointestinal bacteria. To ensure environmental stability in our stickleback facility, we propose to add monitoring equipment that will contact us if environmental conditions within the facility change. This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback.

描述（由申请人提供）：该提案的目的是改善俄勒冈大学斑马鱼和粘性背部设施中的畜牧业。该大学是建立斑马鱼和粘性的世界领导者，作为脊椎动物发育，遗传学和进化研究的模型生物。最近，大学开始专注于使用斑马鱼作为特定人类疾病的模型，包括与胃肠道细菌相互作用可能导致的遗传疾病和疾病。 俄勒冈大学斑马鱼和粘性研究计划的成功导致了水族馆的短缺，需要改进的程序室的需求以及需要其他监视设备以确保环境稳定性的需求。本申请提出以下目的旨在纠正这些情况： 为了满足斑马鱼水族馆日益增长的需求，我们建议用高容量的架子代替许多旧的，破旧的架子。这将大大增加我们可以容纳的斑马鱼的数量，并提供更多的耐腐蚀性和人体工程学设计的住房。 为了提高我们研究胃肠道细菌在肠道发育和功能中的作用的能力，我们建议对斑马鱼程序室进行翻新。这将显着升级我们在没有胃肠细菌的情况下产生和研究无胚斑线的能力。 为了确保我们的粘式背部设施中的环境稳定性，我们建议添加监视设备，如果设施内的环境状况发生变化，将与我们联系。这将大大提高我们确保我们许多遗传上的健康状况，因此不可替代的粘性线的能力。