University of Oregon Animal Resource Improvements

俄勒冈大学动物资源改善

• 批准号: 7433639
• 负责人: JUDITH S EISEN
• 金额: $ 48.33万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2010-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7433639
• 关键词: Animal Husbandry; Animal Model; Condition; Corrosion; Development; Disease; Ensure; Equipment; Gasterosteidae; Germ-Free; Health; Hereditary Disease; Housing; Modeling; Monitor; Numbers; Oregon; Procedures; Research; Resistance; Role; Universities; Zebrafish; animal resource; design; gastrointestinal bacteria; genetic evolution; human disease; improved; programs; success

DESCRIPTION (provided by applicant): The aim of this proposal is to improve animal husbandry in the University of Oregon's zebrafish and stickleback facilities. The University is a world-leader in establishing zebrafish and stickleback as model organisms for research in vertebrate development, genetics and evolution. More recently the University has begun to focus on using zebrafish as a model for specific human diseases, including genetic diseases and diseases that may result from interactions with gastrointestinal bacteria. The success of the zebrafish and stickleback research programs at the University of Oregon has resulted in a shortage of aquaria, the need for an improved procedure room and the need for additional monitoring equipment to ensure environmental stability. This application proposes the following aims to rectify these situations: To meet the increasing demand for zebrafish aquaria, we propose to replace many of our old, dilapidated racks with high-capacity racks. This will significantly increase the number of zebrafish we can house and provide more corrosion resistant and ergonomically-designed housing. To improve our ability to study the role of gastrointestinal bacteria in gut development and function, we propose to renovate a zebrafish procedure room. This will significantly upgrade our ability to produce and study germ free zebrafish reared in the absence of gastrointestinal bacteria. To ensure environmental stability in our stickleback facility, we propose to add monitoring equipment that will contact us if environmental conditions within the facility change. This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback.

描述(由申请人提供)：这项提案的目的是改善俄勒冈大学斑马鱼和刺鱼设施的畜牧业。该大学在建立斑马鱼和刺鱼作为脊椎动物发育、遗传和进化研究的模式生物方面处于世界领先地位。最近，该大学开始专注于将斑马鱼作为研究特定人类疾病的模型，包括遗传性疾病和可能与胃肠道细菌相互作用引起的疾病。 俄勒冈大学斑马鱼和刺鱼研究项目的成功导致水族箱短缺，需要改进的程序室，以及需要额外的监测设备来确保环境稳定。本申请提出以下目的，以纠正这些情况： 为应付对斑马鱼水族箱日益增加的需求，我们建议以高容量的水族箱取代许多破旧的水族箱。这将显著增加我们可以饲养的斑马鱼的数量，并提供更耐腐蚀和符合人体工程学设计的住所。 为了提高我们研究胃肠道细菌在肠道发育和功能中的作用的能力，我们提议翻新一间斑马鱼程序室。这将大大提升我们在没有胃肠道细菌的情况下饲养的无菌斑马鱼的生产和研究能力。 为了确保我们的刺鱼设施的环境稳定，我们建议增加监测设备，如果设施内的环境条件发生变化，这些设备将与我们联系。这将大大提高我们确保我们许多遗传上截然不同的、因此不可替代的刺鱼品系健康的能力。