Establishing the Influences of Childhood Trauma and Adolescent Alcohol Binge Exposures on Reward Functioning Among Young Adult Drinkers

确定童年创伤和青少年酗酒对年轻成年饮酒者奖励功能的影响

• 批准号: 10231905
• 负责人: Hanaan Bing-Canar
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10231905
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Affect; Alcohol Phenotype; Alcohol consumption; Alcohols; Anhedonia; Animals; Behavioral; Characteristics; Chronic Disease; Clinical; Cues; Data; Development; Disease; Early-life trauma; Ethanol; Etiology; Exhibits; Exposure to; Frequencies; Funding; Goals; Human; Individual; Joints; Knowledge; Laboratories; Life; Light; Link; Maintenance; Measures; Mentorship; Modeling; Motivation; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Patient Self-Report; Patients; Phenotype; Physiological; Population; Process; Property; Psychopathology; Psychophysiology; Recording of previous events; Research; Research Personnel; Rewards; Risk; Robin bird; Sampling; Social Environment; Statistical Methods; Stress; Symptoms; System; Techniques; Testing; Training; Translating; Trauma; adolescent binge drinking; adolescent substance use; alcohol abuse therapy; alcohol effect; alcohol exposure; alcohol measurement; alcohol related consequences; alcohol response; alcohol reward; alcohol seeking behavior; alcohol use disorder; career; chronic alcohol ingestion; clinically relevant; comorbidity; depressive symptoms; design; disorder risk; early life exposure; early life stress; emerging adult; emerging adulthood; experience; hedonic; high risk; indexing; multimodality; neural circuit; neuroadaptation; pediatric trauma; recruit; response; reward processing; social; social defeat; statistical learning; stressor; theories; translational model; trauma exposure; traumatic stress; young adult

Project Title: Establishing the Influences of Childhood Trauma and Adolescent Alcohol Binge Exposures on Reward Functioning Among Young Adult Drinkers Project Summary/Abstract: Deficits in reward functioning, including both overvaluation of alcohol rewards and devaluation of non-alcohol rewards, are central to empirically supported models of alcohol use disorder (AUD) etiology and maintenance. Emerging adulthood represents a sensitive risk period for the development of AUD symptoms, particularly among individuals with early life exposures to stress (e.g., childhood trauma) and alcohol. Animal studies support a causal link between early trauma and alcohol exposures and deficits in reward functioning; however, translational human laboratory models are limited. The specific aims of the study are to 1a) investigate differences in subjective and physiological (i.e., corrugator and zygomaticus fEMG) responses to social (i.e., non-alcohol) reward as a function of childhood trauma (CT) and/or adolescent alcohol binge exposures, 1b) evaluate differences in subjective and physiological responses to alcohol reward as a function of CT and/or adolescent alcohol binge exposures, 2) understand alcohol reward response in the context of social reward response, and 3) identify clinical correlates of alcohol and social reward response, with regard to current measures of alcohol (e.g., binge frequency, alcohol drinking motives, alcohol-related consequences) and psychiatric risk (e.g., anhedonia, depressive symptoms). To address these aims, the current study will recruit a sample (N = 100) of young adult drinkers to examine the unique and combined influence of CT and adolescent binge histories on self-report, behavioral, and physiological indices of social (i.e., non-alcohol) and alcohol reward functioning among a population at high-risk for AUD. These study aims will facilitate the primary training goals to 1) develop an understanding of the assessment and interpretation of alcohol-related phenotypes in adolescents and young adults, 2) acquire training in and knowledge of human laboratory models of reward functioning in AUD, 3) obtain clinical training in the assessment and treatment of AUD and comorbid conditions, and 4) gain training in advanced statistical methods. Mentorship provided by experts in human laboratory models of trauma and alcohol use, adolescent substance use risk, and psychophysiology of reward response will advance the candidate’s goals to expand her experience in measurement of alcohol-related phenotypes, human laboratory models of reward processing, and translational models of AUD. Ultimately, the proposed training and research plans will support the candidate’s long-term goal of pursuing a career as a NIAAA-funded independent investigator focused on understanding the interplay between stress and alcohol phenotypes in high-risk young adult populations. The proposed study will be one of the first to evaluate the joint impact of CT and adolescent binge drinking on reward functioning in an effort to inform an integrative model of how these experiences contribute to alterations in hedonic responding and associated AUD risk in young adulthood. This project is directly in line with the NIAAA Strategic Objectives to “study how alcohol affects neural circuits involved in reward.”

项目名称：确定童年创伤和青少年酗酒对儿童的影响 青少年饮酒者的奖励功能 项目摘要/摘要：奖励功能的缺陷，包括对酒精奖励的高估， 非酒精奖励贬值，是酒精使用障碍（AUD）经验支持模型的核心 病因和维护。成年期是AUD发展的敏感风险期 症状，特别是在早期生活暴露于压力的个体中（例如，童年创伤）和酒精。 动物研究支持早期创伤与酒精暴露和奖励缺陷之间的因果关系 然而，翻译人类实验室模型是有限的。研究的具体目标是 1a）调查主观和生理上的差异（即，皱眉肌和颧骨肌fEMG）对 社交（即，非酒精）奖励作为儿童创伤（CT）和/或青少年酗酒的函数 暴露，1b）评估主观和生理反应的差异，酒精奖励的功能， CT和/或青少年酒精狂欢暴露，2）了解社会背景下的酒精奖励反应 奖励反应，以及3）确定酒精和社会奖励反应的临床相关性，就目前而言， 酒精的测量（例如，酗酒频率、饮酒动机、酒精相关后果）， 精神病风险（例如，快感缺乏、抑郁症状）。为了实现这些目标，目前的研究将招募一名 样本（N = 100）的年轻成年饮酒者，以检查CT和青少年的独特和综合影响 关于自我报告、行为和社会的生理指标的狂欢史（即，非酒精）和酒精 奖励功能在AUD高风险人群中发挥作用。这些研究目标将有助于初级培训 目标1）了解酒精相关表型的评估和解释， 青少年和年轻人，2）获得人类实验室奖励模型的培训和知识 在AUD中发挥作用，3）获得AUD和共病状况评估和治疗方面的临床培训， （4）接受先进统计方法的培训。由人体实验室模型专家提供指导 创伤和酒精使用，青少年物质使用风险，以及奖励反应的心理生理学， 推进候选人的目标，以扩大她在测量酒精相关表型，人类 奖励处理的实验室模型和AUD的翻译模型。最后，拟议的培训和 研究计划将支持候选人的长期目标，追求职业生涯作为一个NIAAA资助的独立 研究人员专注于了解高风险年轻人中压力和酒精表型之间的相互作用， 成人人口。这项拟议的研究将是第一个评估CT和青少年的联合影响的研究之一。 酗酒的奖励功能，在努力告知这些经验如何整合模型 有助于改变享乐反应和相关的AUD风险在年轻的成年人。这个项目是 直接符合NIAAA的战略目标，以“研究酒精如何影响参与神经回路， 奖励。”