Epidemiology of Malaria Invasion in Mutare City and Targets for Elimination, Zimbabwe

津巴布韦穆塔雷市疟疾侵袭的流行病学和消除目标

• 批准号: 10297612
• 负责人: Sungano Mharakurwa
• 金额: $ 10.21万
• 依托单位: AFRICA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10297612
• 关键词: Affect; Africa; African; Altitude; Area; Award; Awareness; Back; Behavior; Biological Assay; Biology; Blood; Breeding; Characteristics; Chemoprophylaxis; Child Care; Cities; Collaborations; Collection; Communication; Communities; Conduct Clinical Trials; Country; Culicidae; Data; Data Analyses; Detection; Development; Diagnosis; Disease; Drug resistance; Ensure; Epidemiologic Factors; Epidemiology; Evaluation; Feeding behaviors; Genetic; Genomics; Goals; Grant; Habitats; Health; Health care facility; Healthcare; Human; Infection; Insecticides; International; Intervention; Laboratories; Lead; Malaria; Measures; Mentors; Molecular; Molecular Analysis; Molecular Epidemiology; Monitor; Morphology; Parasites; Pattern; Plasmodium falciparum; Predisposition; Prevalence; Preventive measure; Preventive treatment; Privatization; Prophylactic treatment; Public Health; Publications; Recommendation; Research; Research Personnel; Research Project Grants; Residual state; Risk; Risk Factors; Sampling; Sanitation; Sentinel; Site; Southern Africa; Specimen; Spottings; Surveillance Program; Surveys; Temperature; Testing; Time; Translational Research; Travel; Universities; Work; Writing; Zimbabwe; burden of illness; career; career development; case control; design; diagnostic accuracy; experience; follow-up; histidine-rich proteins; indexing; intervention program; malaria transmission; member; molecular marker; multidisciplinary; operation; programs; restoration; scale up; suburb; symposium; transmission process; uptake; vector; vector control; vector mosquito

Epidemiology of Malaria Invasion in Mutare City and Targets for Elimination, Zimbabwe PROJECT SUMMARY/ABSTRACT This award will enable Dr. Sungano Mharakurwa to ascertain the epidemiological determinants of urban malaria invasion in Zimbabwe in order to identify intervention targets for restoring malaria-free status. The study will leverage on an existing national malaria vector surveillance programme established at Africa University in conjunction with the Ministry of Health and Child Care’s National Malaria Control Programme and its partners. This work will be undertaken with guidance from an experienced team of mentors with strong complementary expertise in public health, epidemiology, transmission biology, parasite genetics, genomics and human studies. Dr. Mharakurwa will further his career development by; 1) conducting and directing the laboratory assays, 2) undertaking short courses in molecular epidemiology, quantitative and sequence data analysis, translation research, conduct of clinical trials and grant-writing; and 3) presenting at international research conferences and writing publications. The program will be pivotal in enabling Dr. Mharakurwa to establish a career and strong collaboration as an independent malaria researcher in Zimbabwe. While Zimbabwe has made significant progress rolling back malaria, a serious setback of reinvasion from endemic to erstwhile malaria-free areas of the country, including highly populated cities, is emerging. The proposed research project will employ molecular and field approaches to understand the seasonal distribution, determinants and characteristics of parasites, vectors and humans associated with urban malaria invasion into Mutare City of Zimbabwe in order to identify strategies for reclaiming zero transmission.

马塔雷市疟疾流行病学及防治目标