Epidemiology of Malaria Invasion in Mutare City and Targets for Elimination, Zimbabwe

穆塔雷市疟疾流行情况及消灭目标， 津巴布韦 项目摘要/摘要 这项奖励将使Sungano Mharakurwa博士能够确定流行病学决定因素 津巴布韦城市疟疾侵袭的研究，以确定恢复疟疾的干预目标 无疟疾状态。这项研究将利用现有的国家疟疾媒介监测 非洲大学与卫生和儿童部联合设立的方案 CARE的国家疟疾控制方案及其合作伙伴。这项工作将由 来自经验丰富的导师团队的指导，这些导师在公共场合具有强大的互补专业知识 健康、流行病学、传播生物学、寄生虫遗传学、基因组学和人类研究。Dr。 Mharakurwa将通过以下方式促进他的职业发展：1)领导和指导实验室 化验，2)参加分子流行病学、定量和序列方面的短期课程 数据分析、翻译研究、进行临床试验和撰写赠款；以及3)介绍 在国际研究会议和撰写出版物。这项计划将在 使Mharakurwa博士能够作为一名独立的 津巴布韦的疟疾研究员。虽然津巴布韦在回落中取得了重大进展 疟疾，从流行地区重新入侵到昔日无疟疾地区的严重挫折 农村，包括人口稠密的城市，正在崛起。拟议的研究项目将 使用分子和现场方法来了解季节分布、决定因素 以及与城市疟疾入侵有关的寄生虫、媒介和人类的特征 进入津巴布韦穆塔雷市，以确定恢复零传播的战略。

Epidemiology of Malaria Invasion in Mutare City and Targets for Elimination, Zimbabwe PROJECT SUMMARY/ABSTRACT This award will enable Dr. Sungano Mharakurwa to ascertain the epidemiological determinants of urban malaria invasion in Zimbabwe in order to identify intervention targets for restoring malaria-free status. The study will leverage on an existing national malaria vector surveillance programme established at Africa University in conjunction with the Ministry of Health and Child Care’s National Malaria Control Programme and its partners. This work will be undertaken with guidance from an experienced team of mentors with strong complementary expertise in public health, epidemiology, transmission biology, parasite genetics, genomics and human studies. Dr. Mharakurwa will further his career development by; 1) conducting and directing the laboratory assays, 2) undertaking short courses in molecular epidemiology, quantitative and sequence data analysis, translation research, conduct of clinical trials and grant-writing; and 3) presenting at international research conferences and writing publications. The program will be pivotal in enabling Dr. Mharakurwa to establish a career and strong collaboration as an independent malaria researcher in Zimbabwe. While Zimbabwe has made significant progress rolling back malaria, a serious setback of reinvasion from endemic to erstwhile malaria-free areas of the country, including highly populated cities, is emerging. The proposed research project will employ molecular and field approaches to understand the seasonal distribution, determinants and characteristics of parasites, vectors and humans associated with urban malaria invasion into Mutare City of Zimbabwe in order to identify strategies for reclaiming zero transmission.