Epidemiology of Malaria Invasion in Mutare City and Targets for Elimination, Zimbabwe

津巴布韦穆塔雷市疟疾侵袭的流行病学和消除目标

• 批准号: 10614654
• 负责人: Sungano Mharakurwa
• 金额: $ 10.21万
• 依托单位: AFRICA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614654
• 关键词: Affect; Africa; African; Altitude; Area; Award; Awareness; Back; Behavior; Biological Assay; Biology; Blood; Breeding; Characteristics; Chemoprophylaxis; Child Care; Cities; Collaborations; Collection; Communication; Communities; Conduct Clinical Trials; Country; Culicidae; Data; Data Analyses; Detection; Development; Diagnosis; Disease; Drug resistance; Dryness; Ensure; Epidemiologic Factors; Epidemiology; Evaluation; Feeding behaviors; Genetic; Genomics; Goals; Grant; Habitats; Health; Health care facility; Healthcare; Human; Infection; Insecticides; International; Intervention; Invaded; Laboratories; Lead; Malaria; Measures; Mentors; Molecular; Molecular Analysis; Molecular Epidemiology; Monitor; Morphology; Parasites; Parasitology; Pattern; Plasmodium falciparum; Predisposition; Prevalence; Preventive measure; Preventive treatment; Privatization; Prophylactic treatment; Public Health; Publications; Recommendation; Research; Research Personnel; Research Project Grants; Residual state; Risk; Risk Factors; Sampling; Sanitation; Seasons; Sentinel; Site; Southern Africa; Specimen; Spottings; Surveillance Program; Surveys; Temperature; Testing; Time; Translational Research; Travel; Universities; Work; Writing; Zimbabwe; burden of illness; career; career development; design; diagnostic accuracy; experience; follow-up; histidine-rich proteins; indexing; intervention program; malaria transmission; member; molecular marker; multidisciplinary; operation; programs; restoration; scale up; suburb; symposium; transmission process; uptake; vector; vector control; vector mosquito

Epidemiology of Malaria Invasion in Mutare City and Targets for Elimination, Zimbabwe PROJECT SUMMARY/ABSTRACT This award will enable Dr. Sungano Mharakurwa to ascertain the epidemiological determinants of urban malaria invasion in Zimbabwe in order to identify intervention targets for restoring malaria-free status. The study will leverage on an existing national malaria vector surveillance programme established at Africa University in conjunction with the Ministry of Health and Child Care’s National Malaria Control Programme and its partners. This work will be undertaken with guidance from an experienced team of mentors with strong complementary expertise in public health, epidemiology, transmission biology, parasite genetics, genomics and human studies. Dr. Mharakurwa will further his career development by; 1) conducting and directing the laboratory assays, 2) undertaking short courses in molecular epidemiology, quantitative and sequence data analysis, translation research, conduct of clinical trials and grant-writing; and 3) presenting at international research conferences and writing publications. The program will be pivotal in enabling Dr. Mharakurwa to establish a career and strong collaboration as an independent malaria researcher in Zimbabwe. While Zimbabwe has made significant progress rolling back malaria, a serious setback of reinvasion from endemic to erstwhile malaria-free areas of the country, including highly populated cities, is emerging. The proposed research project will employ molecular and field approaches to understand the seasonal distribution, determinants and characteristics of parasites, vectors and humans associated with urban malaria invasion into Mutare City of Zimbabwe in order to identify strategies for reclaiming zero transmission.

北京市疟疾流行病学及消灭目标， 津巴布韦 项目总结/摘要 该奖项将使Sungano Mharakurwa博士能够确定流行病学的决定因素， 津巴布韦城市疟疾入侵的研究，以确定恢复 无疟疾状态。这项研究将利用现有的国家疟疾病媒监测系统 与卫生和儿童部合作在非洲大学设立的方案 Care的国家疟疾控制计划及其合作伙伴。这项工作将与 来自经验丰富的导师团队的指导，具有强大的公共互补专业知识 卫生、流行病学、传播生物学、寄生虫遗传学、基因组学和人类研究。博士 Mharakurwa将通过以下方式促进其职业发展：1）管理和指导实验室 分析，2）进行分子流行病学，定量和序列的短期课程 数据分析，翻译研究，临床试验和赠款写作的行为;和3）提出 在国际研究会议和写作出版物。该计划将是关键， 使Mharakurwa博士能够作为一名独立人士建立职业生涯和强有力的合作， 津巴布韦的疟疾研究人员。虽然津巴布韦在减少贫困方面取得了重大进展， 疟疾，从地方病向以前的无疟疾地区重新蔓延的严重挫折， 国家，包括人口密集的城市，正在崛起。拟议的研究项目将 采用分子和场方法来了解季节分布、决定因素 与城市疟疾侵袭有关的寄生虫、病媒和人的特征 在津巴布韦的穆塞韦尼市，以确定恢复零传播的战略。