Sensorimotor integration in the auditory dorsal stream
听觉背侧流中的感觉运动整合
基本信息
- 批准号:10298390
- 负责人:
- 金额:$ 51.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-12-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAgreementAnatomyAnimalsAnterolateralApraxiasAreaAtaxiaAuditoryAuditory areaBehavioralBrainBrain regionCellsClipCognitionCommunicationComplementConsensusDataDiseaseDistantDorsalElectrodesElectrophysiology (science)EvolutionExposure toFunctional Magnetic Resonance ImagingFundingHearingHumanImageLaboratoriesLanguageLanguage DisordersLearningLinkLocationMacaca mulattaMeasuresMicroelectrodesModelingMonkeysMotionMotorMotor CortexMusicNatureNeurodegenerative DisordersNeuronsParietalParietal LobePathway interactionsPerceptionPlayPrefrontal CortexPrimatesProcessProductionPropertyRoleSignal TransductionSpeechSpeech DisordersStimulusStreamStrokeSystemTechniquesTestingTrainingVisualVisual system structureWorkanatomical tracingauditory processingawakebasedensityimprovedinstrumentmulti-electrode arraysmultisensoryneuromechanismnonhuman primatenovelputamenrehabilitation strategyrelating to nervous systemresponsesensorimotor systemsensory systemsoundvisual motor
项目摘要
Project Summary/Abstract
Two cortical pathways originate from early core and belt areas of auditory cortex: a ventral pathway subserving
identification of sounds, and a dorsal pathway that was originally defined – similar to the visual system – as a
processing stream for space and motion. It has been proposed that the auditory dorsal pathway should be
reframed in a wider sense as a processing stream for sensorimotor integration and control (Rauschecker,
2011). This broader function explicitly includes spatial processing but also extends to the processing of
auditory-motor sequences, including spoken speech and musical melodies in humans. In this long-term
project, we will test the expanded model of the auditory dorsal stream by training rhesus monkeys to produce
sound sequences on a new behavioral apparatus (“monkey piano”) developed in our laboratory (Archakov et
al., 2020). By pressing a lever, the monkey produces a tone of a specific pitch; by pressing several levers in
succession, the monkey produces a melody. After an animal has learned to reliably play the same sequence,
auditory-responsive brain regions are identified through whole-brain functional magnetic resonance imaging
(fMRI) while the animal is alert and listens to the learned self-produced sequence. Control stimuli include
melodies the monkey has been passively exposed to, and novel melodies that the monkey has never heard
before. Results from the previous funding cycle show that listening to the self-produced melody activates not
only auditory areas but also motor regions of the brain, thus demonstrating the existence of internal models
linking perception and action. The locations of activated regions will now guide electrophysiological recording
with linear microelectrode arrays (LMAs). We will record neuronal responses in auditory and motor regions of
cortex to passive listening of the sound sequences and compare them to neuronal activity obtained when the
monkey actively produces the sequence with and without sound. Finally, we will add video of a monkey playing
the sound sequence on the monkey piano and study multisensory interactions along the dorsal stream using
fMRI and LMAs. In particular, responses in caudal auditory belt and parabelt will be compared with those in
premotor cortex and posterior parietal cortex in simultaneous recordings. Our studies, using alert monkeys
trained in a behavioral task, will contribute to the understanding of unified principles of perception and cognition
across sensory systems and their interactions with the motor system in the form of internal models.
Investigating the auditory dorsal stream in a nonhuman primate will provide essential information on the origin
of human communication, including speech and music. Our studies are relevant for higher–level processing
disorders of speech and its production, such as apraxia of speech, non-fluent aphasia, and specific language
disorders that involve inadequate coordination between sensory and motor systems. The results will also
improve our understanding of sensorimotor disorders, such as ataxia, which may be caused by stroke or
neurodegenerative disease, thus leading to better therapies and rehabilitation strategies.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSEF P RAUSCHECKER其他文献
JOSEF P RAUSCHECKER的其他文献
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{{ truncateString('JOSEF P RAUSCHECKER', 18)}}的其他基金
Sensory-motor integration in the auditory dorsal stream
听觉背侧流中的感觉运动整合
- 批准号:
9380340 - 财政年份:2015
- 资助金额:
$ 51.75万 - 项目类别:
Sensorimotor integration in the auditory dorsal stream
听觉背侧流中的感觉运动整合
- 批准号:
10670957 - 财政年份:2015
- 资助金额:
$ 51.75万 - 项目类别:
Sensory-motor integration in the auditory dorsal stream
听觉背侧流中的感觉运动整合
- 批准号:
9178657 - 财政年份:2015
- 资助金额:
$ 51.75万 - 项目类别:
Sensorimotor integration in the auditory dorsal stream
听觉背侧流中的感觉运动整合
- 批准号:
10414990 - 财政年份:2015
- 资助金额:
$ 51.75万 - 项目类别:
Sensory-motor integration in the auditory dorsal stream
听觉背侧流中的感觉运动整合
- 批准号:
10171668 - 财政年份:2015
- 资助金额:
$ 51.75万 - 项目类别:
Sensory Cortical Organization and Cross-Modal Plasticity in Blind Humans
盲人的感觉皮层组织和跨模式可塑性
- 批准号:
9113167 - 财政年份:2009
- 资助金额:
$ 51.75万 - 项目类别:
Sensory cortical organization and cross-modal plasticity in blind subjects
盲人受试者的感觉皮层组织和跨模式可塑性
- 批准号:
7895576 - 财政年份:2009
- 资助金额:
$ 51.75万 - 项目类别:
Sensory Cortical Organization and Cross-Modal Plasticity in Blind Humans
盲人的感觉皮层组织和跨模式可塑性
- 批准号:
8514241 - 财政年份:2009
- 资助金额:
$ 51.75万 - 项目类别:
Sensory Cortical Organization and Cross-Modal Plasticity in Blind Humans
盲人的感觉皮层组织和跨模式可塑性
- 批准号:
8691821 - 财政年份:2009
- 资助金额:
$ 51.75万 - 项目类别:
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