Cell Electrophysiology Core

细胞电生理学核心 总结 此核心的主要目的是支持基础架构， 特拉华州神经科学界的研究人员， 电生理学方法来回答他们的研究问题。细胞电生理 提供了独特的功能评估和兴奋细胞，组织， 和离子通道。然而，电生理学实验需要昂贵的， 专业设备，以及多年的时间来发展必要的技术技能，数据收集和分析， 因此对于不专门研究该领域的实验室来说是遥不可及的。这一核心是作为 我们的第二阶段COBRE是为了响应特拉华州生物医学研究界的需求评估， 在全州范围内确定了13名外部资助的研究人员，他们希望收集电生理数据， 数据从他们的模型系统，但缺乏这样做的手段。一项对研究生的调查在一年一度的 2018年特拉华州神经科学研讨会发现，许多人希望获得细胞电生理学方面的经验 以扩大他们的研究项目的范围和扩大他们的技术储备。 来自我们的特拉华州神经科学研究中心COBRE和全州特拉华州IDEA的支持 生物医学研究卓越网络（INBRE）使得能够购买电生理仪器 支持传统膜片钳、多电极阵列记录和自动膜片钳，确保 最先进的仪器我们的核心将为特拉华州的神经科学家提供电生理学 技术，经验丰富的合作者和咨询专业知识，这将增加他们的创新和影响力。 研究，使他们更有竞争力的外部资金。通过第三阶段COBRE奖继续提供支持 将允许广泛传播我们的CE核心，其仪器和服务的可用性。在我们的 第三阶段的合同，我们预计我们的CE核心将产生可衡量的下游影响，包括增加数量 特拉华州州立大学是一所历史上的黑人大学， 以及整个特拉华州。研究活动水平的提高将提供新的研究和培训 为本科生和研究生的机会都在DSU和其他机构在特拉华州。

Cell Electrophysiology Core Summary The primary purpose for this core is to support infrastructure to provide investigators in the neuroscience community in Delaware with access to electrophysiological methods to answer their research questions. Cell electrophysiology provides unique functional assessment and characterization of excitable cells, tissues and ion channels. However, electrophysiological experiments require expensive, specialized equipment, as well as years of time to develop the necessary technical skills for data collection and analysis, and are therefore out of reach for laboratories that are not specialized in that area. This core was established as part of our Phase II COBRE in response to a needs-assessment among the biomedical research community in Delaware that identified a pool of 13 externally-funded researchers throughout the state who wanted to collect electrophysiological data from their model systems, but lacked the means to do so. A survey of graduate students conducted at the annual Delaware Neuroscience Symposium in 2018 found many would like to get some experience with cell electrophysiology to expand the scope of their research projects and broaden their repertoire of techniques. Support from our Delaware Center for Neuroscience Research COBRE and the statewide Delaware IDeA Network of Biomedical Research Excellence (INBRE) enabled the purchase of electrophysiology instrumentation supporting traditional patch clamp, multi-electrode array recordings, and automated patch clamp, ensuring state-of- the-art instrumentation in the core. Our core will provide Delaware neuroscientists access to electrophysiological techniques, experienced collaborators and consulting expertise that will increase the innovation and impact of their research and make them more competitive for external funding. Continued support through a Phase III COBRE award will allow broad dissemination of the availability of our CE Core, its instrumentation and services. By the end of our Phase III award we expect that our CE Core will have measurable downstream impacts including increased numbers of research publications and greater external funding at Delaware State University, an Historically Black university, as well as across the state of Delaware. The increased level of research activity will provide new research and training opportunities for undergraduate and graduate students both within the DSU and other institutions in Delaware.