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Dopamine synapses and operant conditioning

多巴胺突触和操作性条件反射

基本信息

批准号：
10298002
负责人：
David Sulzer
金额：
$ 4.53万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
起止时间：
1991-07-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10298002
关键词：
Action Potentials Address Amphetamines Animals Antipsychotic Agents Attention Deficit Disorder Attentional deficit Axon Behavior Behavioral CNR1 gene Calcium Cannabinoids Chemicals Cholinergic Receptors Complex Corpus striatum structure Coupled Cues Data Decision Making Dopamine Dopaminergic Agents Drug abuse Electrochemistry Endocannabinoids Environment Exhibits Future Glutamates Hippocampus (Brain)Image Individual Interneurons Kinetics Laboratories Learning Measures Mediating Motor Muscarinic Acetylcholine Receptor Neurons Neurotransmitters Operant Conditioning Opioid Optics Organism Output Parkinson Disease Pathway interactions Periodicity Pharmaceutical Preparations Photons Probability Protocols documentation Psychoses Regulation Response to stimulus physiology Rewards Role Schizophrenia Self Administration Self Stimulation Sensory Signal Transduction Site Slice Stimulus Structure Synapses Techniques Testing Thalamic structure Time addiction cannabinoid receptor cholinergic cholinergic neuron experience experimental study in vivo learned behavior motor learning neural circuit neural correlate neuromuscular neurotransmission neurotransmitter release novel operation postsynaptic presynaptic quantum receptor response sensor sensory gating sensory stimulus synaptic function transmission process voltage

项目摘要

Abstract: The dopaminergic (DA) synapse has been studied since the 1950s, when it was implicated in motor function, actions of antipsychotic drugs, and drug abuse. The study of DA synapses has however lagged behind that of other synapses, due to a lack of means to record dopamine release. To address this, chemical techniques have been developed, in particular electrochemical recording techniques and fluorescent false neurotransmitters (FFNs), that provide the first optical measure of neurotransmitter release from individual presynaptic sites. From these techniques, in some ways, we now know more about DA synapses than any other in the CNS. Here, we extend the contemporary understanding of DA synapses to reveal their roles in the interaction of higher organisms with the environment. This is now possible due to technical and conceptual advances, including the use of techniques novel to this proposal, including FFNs and DA-specific voltage sensors. This project tests if a) an interaction between sensory-related and reward-related excitation “gates” local DA release, and whether this is required for normal learning and behavior; b) DA filters excitation by specific interactions with cannabinoid receptors to mediate decision-making and learning, c) learned behaviors that become established “refine” synaptic circuits by selectively decreasing local DA activity, and that this enables future learning. The results of these experiments promise to indicate how addictive drugs such as amphetamine and opiates act to disrupt the normal operation of these steps.

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