Basic Neuroscience Training Grant at Columbia University

哥伦比亚大学基础神经科学培训补助金

• 批准号: 7869590
• 负责人: David Sulzer
• 金额: $ 17.93万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7869590
• 关键词: Grant; Neurosciences; Training; Universities

DESCRIPTION (provided by applicant): This competing renewal of the Columbia University Neuroscience training grant is designed to support eight postdoctoral scientists per year in a multi-departmental training program devoted to basic neuroscience research that elucidates basic neural mechanisms associated with drugs of abuse. Sixteen faculty from basic and clinical departments with interest and expertise in this area act as mentors. Their laboratories address basic molecular steps in the reward pathway, encompassing acetylcholine, dopamine, and serotonin receptors, dopamine uptake transporters, circuitry, development, and the mechanism of action of psychostimulant drugs as well as neurotoxic and neuropsychiatric consequences that stem from the actions of these compounds. While Columbia University has a long-standing training grant to provide support for clinical research in drug abuse, this is the sole training program in basic research in drug abuse. We believe that the institution provides a strong, and in some ways unique, environment to provide an in depth focus in this area, along with a strong group of proven investigators with demonstrable records of providing first-rate guidance and training to junior investigators. PUBLIC HEALTH RELEVANCE: The purpose of this proposal is to fund postdoctoral scientists in a sixteen laboratories at Columbia University Medical school to develop their scientific expertise and provide the new generation of scientists devoted to understanding the biological cause and consequences of substance abuse.

描述（由申请人提供）：哥伦比亚大学神经科学培训补助金的这种竞争性更新旨在在多部门培训计划中支持八名博士后科学家，该计划致力于基本的神经科学研究，阐明了与滥用药物相关的基本神经机制。来自基础和临床部门的16位教师在该领域具有兴趣和专业知识，作为导师。他们的实验室解决了奖励途径中的基本分子步骤，包括乙酰胆碱，多巴胺和5-羟色胺受体，多巴胺摄取转运蛋白，电路，发育以及精神刺激药物的作用机理，以及神经毒性和神经心理性的影响以及这些综合作用的作用。尽管哥伦比亚大学拥有长期的培训补助金，以支持药物滥用的临床研究，但这是药物滥用基础研究的唯一培训计划。我们认为，该机构在某些方面提供了一个独特的环境，可以在这一领域提供深入的重点，并提供了一群可靠的研究人员，并有可证明的记录，这些记录是为初级调查人员提供一流的指导和培训。 公共卫生相关性：该提案的目的是在哥伦比亚大学医学院的16个实验室中为博士后科学家提供资金，以发展其科学专业知识，并为了解滥用药物的生物学原因和后果的新一代科学家提供。