Basic Neuroscience Training Grant at Columbia University

描述（由申请人提供）：哥伦比亚大学神经科学培训补助金的竞争性更新，旨在每年支持8名博士后科学家参加一个多部门培训计划，致力于基础神经科学研究，阐明与药物滥用相关的基本神经机制。来自基础和临床部门的16位对该领域感兴趣和专业知识的教师担任导师。他们的实验室研究奖励通路中的基本分子步骤，包括乙酰胆碱、多巴胺和血清素受体、多巴胺摄取转运体、回路、发育和精神兴奋剂药物的作用机制，以及源于这些化合物作用的神经毒性和神经精神后果。虽然哥伦比亚大学有一个长期的培训补助金，为药物滥用的临床研究提供支持，但这是唯一一个药物滥用基础研究的培训项目。我们相信，该机构提供了一个强大的，在某种程度上是独特的，环境，以提供深入关注这一领域，以及一个强大的经验丰富的调查人员团队，他们为初级调查人员提供一流的指导和培训。

DESCRIPTION (provided by applicant): This competing renewal of the Columbia University Neuroscience training grant is designed to support eight postdoctoral scientists per year in a multi-departmental training program devoted to basic neuroscience research that elucidates basic neural mechanisms associated with drugs of abuse. Sixteen faculty from basic and clinical departments with interest and expertise in this area act as mentors. Their laboratories address basic molecular steps in the reward pathway, encompassing acetylcholine, dopamine, and serotonin receptors, dopamine uptake transporters, circuitry, development, and the mechanism of action of psychostimulant drugs as well as neurotoxic and neuropsychiatric consequences that stem from the actions of these compounds. While Columbia University has a long-standing training grant to provide support for clinical research in drug abuse, this is the sole training program in basic research in drug abuse. We believe that the institution provides a strong, and in some ways unique, environment to provide an in depth focus in this area, along with a strong group of proven investigators with demonstrable records of providing first-rate guidance and training to junior investigators. PUBLIC HEALTH RELEVANCE: The purpose of this proposal is to fund postdoctoral scientists in a sixteen laboratories at Columbia University Medical school to develop their scientific expertise and provide the new generation of scientists devoted to understanding the biological cause and consequences of substance abuse.