Personalized assessment of bladder cancer treatment response using urinary molecular biomarkers
使用尿液分子生物标志物对膀胱癌治疗反应进行个性化评估
基本信息
- 批准号:10293596
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-10-01 至 2024-09-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAfghanistanAromatic AminesAwarenessBCG LiveBacillus Calmette-Guerin TherapyBenignBiologicalBiological MarkersBladderBloodCancer DetectionCancer PatientCessation of lifeChemical ExposureClinicClinicalClinical ResearchClinical TrialsClinical Trials DesignCollaborationsCystoscopyCytologyDataDecision MakingDevelopmentDiagnosisDiagnosticDiagnostic SensitivityDiseaseDoctor of PhilosophyEmotionalEnvironmental ExposureEpidemiologistExposure toFoundationsGeneral PopulationGoalsHealthHealth Services AccessibilityHematuriaHigh-Throughput RNA SequencingHospitalsIraqLesionLiquid substanceMalignant NeoplasmsMalignant neoplasm of urinary bladderMeasurementMeasuresMedicalMessenger RNAMicrofluidicsMicroscopicModelingMolecularMonitorMorbidity - disease rateNucleic AcidsOperative Surgical ProceduresParticulatePatientsPerformancePopulationPrediction of Response to TherapyProceduresRecording of previous eventsRecurrenceResearchResearch DesignResearch PersonnelResidual CancersRiskRisk FactorsSamplingScientistScreening for cancerServicesSmokeSmokingSolidSymptomsTechnologyTestingTherapeutic InterventionTimeTobacco useTranslationsTransurethral ResectionTumor-DerivedUrineUrologic DiseasesUrologic OncologyUrologic SurgeonValidationVeteransVietnamagent orangebasebiomarker discoverybiomarker panelburden of illnesscancer riskcancer typeclinical translationdiagnostic strategydiagnostic toolexperiencefallshigh riskimprovedimproved outcomeintravesicalmolecular diagnosticsmolecular markernon-muscle invasive bladder cancerpatient stratificationpersonalized approachpersonalized medicinepersonalized therapeuticprospectiveresponserisk stratificationscreeningtooltreatment responsetreatment strategytumorurinaryvalidation studies
项目摘要
Bladder cancer is the sixth most common cancer in the U.S., has one of the highest recurrence rates of all solid
cancers, and is the most expensive cancer to treat from diagnosis to death. Veterans are at increased risk for
bladder cancer due higher rates of tobacco use and environmental exposure. There are significant unmet needs
for biomarkers and molecular diagnostic tools to better inform decision making across all stages of bladder
cancer. For patients with early stage disease, current diagnostic approaches are either invasive (e.g. cystoscopy)
or lack sensitivity (e.g. urine cytology). We propose to develop molecular diagnostics that will lead to more
effective and personalized therapeutic strategies for patients with localized bladder cancer. Tumor-derived
nucleic acids in biological fluids such as urine represent promising biomarkers for non-invasive measurement of
disease burden and response to therapy. Previously, we developed a pipeline for bladder cancer biomarker
discovery, validation, and technology integration for clinical translation. We applied high throughput RNA
sequencing of urinary sediments as a biomarker discovery tool and identified a urinary mRNA (u-mRNA) panel
with promising diagnostic performance. In parallel, we validated an integrated microfluidics cartridge capable
of “sample-in, answer-out” within 90 minutes using a separate u-mRNA panel. Our recent preliminary data
indicate further improvement of diagnostic performance by combining the two panels within the integrated
cartridge. Based on these promising preliminary data, we propose three specific aims: 1) to validate the
optimized mRNA panel for bladder cancer surveillance and risk stratification; 2) to validate the optimized u-
mRNA panel to improve bladder cancer screening and assess risk stratification; and 3) to validate the optimized
u-mRNA panel for response assessment and monitoring in patients with high risk NMIBC treated with BCG
immunotherapy. Our team is led by experienced academic VA investigators with complimentary expertise in
molecular diagnostics (Liao), urologic oncology (Liao, Leppert), and clinical validation study design (Liao, Yu).
Successful completion of the studies proposed here will serve as a foundation for incorporating urine-based
biomarkers in bladder cancer surveillance and into prospective clinical trials to assess therapeutic interventions.
We foresee that our approach will allow personalization of treatment strategies to improve outcomes for BC
patients in both veterans and the general population.
膀胱癌是美国第六大最常见的癌症,是所有固体癌症中复发率最高的之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JOSEPH C LIAO其他文献
JOSEPH C LIAO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JOSEPH C LIAO', 18)}}的其他基金
Intraoperative integration of artificial intelligence during cystoscopic surgery
膀胱镜手术中人工智能的术中整合
- 批准号:
10365872 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Intraoperative integration of artificial intelligence during cystoscopic surgery
膀胱镜手术中人工智能的术中整合
- 批准号:
10544344 - 财政年份:2022
- 资助金额:
-- - 项目类别:
BCCMA: Basic and Translational Mechanisms of Cancer Initiation of the Urothelium in Veterans Exposed to Carcinogens: Leveraging Artificial Neural Networks to Enhance Detection of Carcinoma in situ
BCCMA:暴露于致癌物的退伍军人尿路上皮癌症发生的基本和转化机制:利用人工神经网络增强原位癌的检测
- 批准号:
10260145 - 财政年份:2021
- 资助金额:
-- - 项目类别:
MagSToNE - a magnetic system for kidney stone fragment elimination
MagSToNE - 用于消除肾结石碎片的磁性系统
- 批准号:
10354258 - 财政年份:2021
- 资助金额:
-- - 项目类别:
MagSToNE - a magnetic system for kidney stone fragment elimination
MagSToNE - 用于消除肾结石碎片的磁性系统
- 批准号:
10491338 - 财政年份:2021
- 资助金额:
-- - 项目类别:
BCCMA: Basic and Translational Mechanisms of Cancer Initiation of the Urothelium in Veterans Exposed to Carcinogens: Leveraging Artificial Neural Networks to Enhance Detection of Carcinoma in situ
BCCMA:暴露于致癌物的退伍军人尿路上皮癌症发生的基本和转化机制:利用人工神经网络增强原位癌的检测
- 批准号:
10513315 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Personalized assessment of bladder cancer treatment response using urinary molecular biomarkers
使用尿液分子生物标志物对膀胱癌治疗反应进行个性化评估
- 批准号:
10514572 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Personalized assessment of bladder cancer treatment response using urinary molecular biomarkers
使用尿液分子生物标志物对膀胱癌治疗反应进行个性化评估
- 批准号:
10015540 - 财政年份:2020
- 资助金额:
-- - 项目类别:
A Droplet-based single cell platform for pathogen identification and AST
用于病原体识别和 AST 的基于 Droplet 的单细胞平台
- 批准号:
8875827 - 财政年份:2015
- 资助金额:
-- - 项目类别:
A Droplet-based single cell platform for pathogen identification and AST
用于病原体识别和 AST 的基于 Droplet 的单细胞平台
- 批准号:
9038992 - 财政年份:2015
- 资助金额:
-- - 项目类别:
相似海外基金
Drought and Climate Resilience of Smallholders in Afghanistan: Needs and Preferences Analysis
阿富汗小农的干旱和气候抵御能力:需求和偏好分析
- 批准号:
24K16366 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Early-Career Scientists
'Diaspora States' in Somalia and Afghanistan: New Perspectives on Post-War Politics, Dual Citizenship and International Statebuilding
索马里和阿富汗的“侨民国家”:战后政治、双重国籍和国际国家建设的新视角
- 批准号:
EP/X022048/1 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Fellowship
Improving learning outcomes in Afghanistan and Pakistan in the midst of COVID-19 through Community based system dynamics and project-based learning
通过基于社区的系统动态和基于项目的学习,在 COVID-19 期间改善阿富汗和巴基斯坦的学习成果
- 批准号:
ES/X014088/1 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Research Grant
On Politics and Justice: British Military Justice following War Crimes Allegations in Iraq and Afghanistan, 2001-present
论政治与司法:2001 年至今,伊拉克和阿富汗战争罪指控后的英国军事司法
- 批准号:
2745904 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Studentship
U.S and Afghanistan - why the nation-building project failed?
美国和阿富汗——国家建设项目为何失败?
- 批准号:
22K01385 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Market Economy and Conflict; Disjuncture between the Politics and Economics of Statebuilding in Afghanistan during 2001-2021
市场经济与冲突;
- 批准号:
ES/X006832/1 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Fellowship
Analysis of the structure of conflict between ethnicities in the transformation of national integration policy in Afghanistan
阿富汗民族融合政策转型中的族群冲突结构分析
- 批准号:
19K20529 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Early-Career Scientists
Neurosteroid Intervention for PTSD in Iraq/Afghanistan-era Veterans
神经类固醇干预伊拉克/阿富汗时期退伍军人的创伤后应激障碍
- 批准号:
10417141 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Neurosteroid Intervention for PTSD in Iraq/Afghanistan-era Veterans
神经类固醇干预伊拉克/阿富汗时期退伍军人的创伤后应激障碍
- 批准号:
10589071 - 财政年份:2019
- 资助金额:
-- - 项目类别:
A pilot assessment of miltefosine's efficacy and tolerability for treating cutaneous Leishmania tropica in Afghanistan
在阿富汗对米替福辛治疗皮肤热带利什曼原虫的疗效和耐受性进行初步评估
- 批准号:
MR/R018391/1 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Research Grant