Causal Restructuring of Neural Rhythms Improves Adaptive Behavior

神经节律的因果重组可改善适应性行为

• 批准号: 10299619
• 负责人: Robert Reinhart
• 金额: $ 41.25万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-27 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10299619
• 关键词: Adaptive Behaviors; Anodes; Architecture; Area; Attention deficit hyperactivity disorder; Avoidance Learning; Basic Science; Behavior; Behavior Control; Behavioral; Behavioral Mechanisms; Beta Rhythm; Boston; Brain; Brain Diseases; Cathodes; Clinical; Cognition; Cognitive; Communication; Computer Models; Data; Data Collection; Development; Double-Blind Method; Electric Stimulation; Electroencephalography; Electrophysiology (science); Ensure; Environment; Failure; Feedback; Frequencies; Gilles de la Tourette syndrome; Goals; Hour; Human; Impairment; Individual; Intervention; Knowledge; Laboratories; Lateral; Learning; Maintenance; Measurement; Measures; Medial; Methodology; Methods; Modality; Modeling; Motor; Motor Cortex; Neurosciences; Neurosciences Research; Parkinson Disease; Performance; Periodicity; Pharmaceutical Preparations; Phase; Physiological; Prefrontal Cortex; Procedures; Punishment; Reproducibility; Research; Research Personnel; Rewards; Sample Size; Schizophrenia; Sensory; Signal Transduction; Source; System; Techniques; Technology; Testing; Theta Rhythm; Universities; adaptive learning; addiction; autism spectrum disorder; base; behavior measurement; density; executive function; experimental study; flexibility; frontal lobe; improved; indexing; information processing; insight; interest; learned behavior; neuroimaging; neuromechanism; neurophysiology; neuropsychiatric disorder; neuroregulation; neurotransmission; next generation; noninvasive brain stimulation; novel; patient population; power analysis; programs; reconstruction; relating to nervous system; response; sensory cortex; success; support network; tool

PROJECT SUMMARY/ABSTRACT Humans have a remarkable capacity to adapt to changing circumstances and learn new information from feedback in the environment. Failures to use feedback to adapt or maintain behavior are implicated in a wide variety of brain disorders, including schizophrenia 1, addiction 2, autism 3, Parkinson's disease 4,5, Tourette syndrome 6, and attention deficit hyperactive disorder 6. A better understanding of the neural mechanisms underlying feedback processing and learning has the potential to bridge neuroscience research across a range of species and theoretical and methodological frameworks, and to help gain insight into brain disorders. This project examines the mechanisms of positive and negative feedback-guided learning in healthy humans from a physiologically inspired perspective centered on large-scale brain networks and how they interact through synchronized electrophysiological rhythms 7,8. We focus on rhythms hypothesized to index frontal cortical mechanisms that compute and communicate the need for adjustment or maintenance of current information processing across broad networks during learning. We combine high-density electroencephalographic (EEG) measurements of synchronized rhythms with high definition transcranial direct-current stimulation (HD-tDCS) 9,10 to determine whether it is possible to modify components of frontal activity and cause bi-directional changes in next-trial behavior and learning success. Our preliminary data are highly encouraging and indicate that we can causally manipulate the timing of low-frequency rhythmic activity, and improve or impair learning measured behaviorally. The goals of the research program are to use novel neuroscience tools and analysis procedures to gain a deeper understanding of the cognitive mechanisms underlying the flexible adjustment of behavior and learning, and contribute new knowledge to the development of effective, non-pharmacological interventions for improving cognition in healthy and patient populations.

项目概要/摘要 人类具有适应不断变化的环境并从中学习新信息的非凡能力 环境中的反馈。未能利用反馈来适应或维持行为涉及广泛的问题 多种脑部疾病，包括精神分裂症 1、成瘾 2、自闭症 3、帕金森病 4,5、抽动秽语 综合症 6 和注意力缺陷多动障碍 6。更好地了解神经机制 潜在的反馈处理和学习有潜力在一系列神经科学研究中架起桥梁 物种以及理论和方法框架，并帮助深入了解大脑疾病。这 该项目研究了健康人类在积极和消极反馈引导下的学习机制 受生理学启发的观点集中于大规模的大脑网络以及它们如何通过 同步电生理节律7,8。我们关注假设为索引额叶皮质的节律 计算和传达调整或维护当前信息的需求的机制 在学习过程中跨广泛的网络进行处理。我们结合高密度脑电图 (EEG) 使用高清经颅直流电刺激 (HD-tDCS) 测量同步节律 9,10 确定是否有可能修改额叶活动的组成部分并引起双向 下一次试验行为和学习成功的变化。我们的初步数据非常令人鼓舞并表明 我们可以因果地操纵低频节律活动的时间，并改善或损害学习 通过行为来衡量。该研究计划的目标是使用新颖的神经科学工具和分析 程序来更深入地了解灵活调整的认知机制 行为和学习，并为开发有效的非药理学贡献新知识 改善健康人群和患者认知的干预措施。

项目成果

Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation.

重复神经调节的老年人的长期工作记忆和长期记忆的长期改善。

• DOI: 10.1038/s41593-022-01132-3
• 发表时间: 2022-09
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Grover, Shrey;Wen, Wen;Viswanathan, Vighnesh;Gill, Christopher T.;Reinhart, Robert M. G.
• 通讯作者: Reinhart, Robert M. G.

Modulating Anterior Midcingulate Cortex Using Theta Burst Stimulation.

• DOI: 10.1016/j.bpsc.2020.09.002
• 发表时间: 2020-11
• 期刊: Biological psychiatry. Cognitive neuroscience and neuroimaging

Synchronizing neural rhythms.

• DOI: 10.1126/science.add4834
• 发表时间: 2022-08-05
• 期刊: Science (New York, N.Y.)

Alpha suppression indexes a spotlight of visual-spatial attention that can shine on both perceptual and memory representations.

Alpha 抑制索引了视觉空间注意力的聚光灯，可以照亮感知和记忆表征。

• DOI: 10.3758/s13423-021-02034-4
• 发表时间: 2022
• 期刊: Psychonomic bulletin & review
• 影响因子: 3.5
• 作者: Woodman,GeoffreyF;Wang,Sisi;Sutterer,DavidW;Reinhart,RobertMG;Fukuda,Keisuke
• 通讯作者: Fukuda,Keisuke

High-frequency neuromodulation improves obsessive-compulsive behavior.

• DOI: 10.1038/s41591-020-01173-w
• 发表时间: 2021-03
• 期刊: NATURE MEDICINE
• 影响因子: 82.9
• 作者: Grover, Shrey;Nguyen, John A.;Viswanathan, Vighnesh;Reinhart, Robert M. G.
• 通讯作者: Reinhart, Robert M. G.